Gastric outlet obstruction due to adenocarcinoma in a patient with Ataxia-Telangiectasia syndrome: a case report and review of the literature

Background: Ataxia-Telangiectasia syndrome is characterized by progressive cerebellar dysfunction, conjuctival and cutaneous telangiectasias, severe immune deficiencies, premature aging and predisposition to cancer. Clinical and radiographic evaluation for malignancy in ataxia-telangiectasia patients is usually atypical, leading to delays in diagnosis. Case presentation: We report the case of a 20 year old ataxia-telangiectasia patient with gastric adenocarcinoma that presented as complete gastric outlet obstruction. Conclusion: A literature search of adenocarcinoma associated with ataxia-telangiectasia revealed 6 cases. All patients presented with non-specific gastrointestinal complaints suggestive of ulcer disease. Although there was no correlation between immunoglobulin levels and development of gastric adenocarcinoma, the presence of chronic gastritis and intestinal metaplasia seem to lead to the development of gastric adenocarcinoma. One should consider adenocarcinoma in any patient with ataxia-telangiectasia who presents with non-specific gastrointestinal complaints, since this can lead to earlier diagnosis

Genotype Prevalence and Risk Factors for Severe Clinical Adenovirus Infection, United States 2004-2006

Recently, epidemiological and clinical data have revealed important changes with regard to clinical adenovirus infection, including alterations in antigenic presentation, geographical distribution, and virulence of the virus

Trajectories of Positive and Negative Behavior During Participation in Equine Facilitated Learning Program for Horse-Novice Youth

To explore the efficacy of equine programming to support positive behavioral development of horse-novice youth, researchers examined trajectories of behavioral change of 5-8th grade students as they participate in an equine facilitated learning program. Behaviors were rated and analyzed to examine group trajectories of change. Results indicated significant increases and decreases in mean levels of participants\u27 positive and negative behaviors respectively (M pos = 17.13, p = .000; M neg = 4.76 ; p = .005). Additionally, researchers describe how program principles can be incorporated into 4-H curricula, expanding positive youth development opportunities for horse-novice and horse-experienced youth