The Co-Strategy Process: introducing technology through interdisciplinary collaboration, so it meets biology in society : A case study regarding the path of Robot-Assisted-Rehabilitation from laboratory to patients in Sweden

As part of the current fast growing development of digital technologies, collaborations between professions such as neurosciences, robotics, big data processing and artificial intelligence offer new possibilities for healthcare. For these new technologies to reach clinical practice, there is an increasing need for interdisciplinary organizational work to support decision-making over their introduction. In the field of neurorehabilitation, exoskeletons are an example of a robotic tool that can be used to regain locomotion abilities after a neurological injury. They are part of an umbrella term, Robot-Assisted-Rehabilitation (RAR), that stands for neurological recovery techniques assisted with robotic tools. For these tools, the introduction, evaluation and implementation in clinical practice have not been evaluated. In many cases it is also not taken into account that tools such as rehabilitation robotics are context-dependent. In other words, the needs, opportunities and challenges that come together with working efficiently with this new technology can widely vary between clinics, regions and countries. Lastly, it appears that smaller hospitals consider themselves in need of tools to support their decision-making in the RAR introduction phase. In collaboration with Hälsostaden and Region Skåne, we set out to develop a tool to support Ängelholm Hospital (ÄH) in their decision-making over a test-bed trial of RAR in their clinical setting. A tool that we coined the Co-Strategy Process (CSP), was developed based on identified needs related to this stage of the process, using a blend of interdisciplinary scientific methods. It integrates internal and external interdisciplinary expertise and includes four steps: Preparation, Knowledge Empowerment, Exchange & Development and Synthesis & Report. The current Master thesis presents the development and assessment of the CSP at ÄH. In the present context, it results in a new tool for supporting organizations implementing new technologies, optimized based on its application in a Swedish clinical setting. This tool aims at serving this introductory process, so that new technologies can be implemented meeting the needs of both the clinic and patients.e Rehab-robotic project in collaboration with Uppsala University, Basel University and ETH Zuric

The Co-Strategy Process: introducing technology through interdisciplinary collaboration, so it meets biology in society : A case study regarding the path of Robot-Assisted-Rehabilitation from laboratory to patients in Sweden

As part of the current fast growing development of digital technologies, collaborations between professions such as neurosciences, robotics, big data processing and artificial intelligence offer new possibilities for healthcare. For these new technologies to reach clinical practice, there is an increasing need for interdisciplinary organizational work to support decision-making over their introduction. In the field of neurorehabilitation, exoskeletons are an example of a robotic tool that can be used to regain locomotion abilities after a neurological injury. They are part of an umbrella term, Robot-Assisted-Rehabilitation (RAR), that stands for neurological recovery techniques assisted with robotic tools. For these tools, the introduction, evaluation and implementation in clinical practice have not been evaluated. In many cases it is also not taken into account that tools such as rehabilitation robotics are context-dependent. In other words, the needs, opportunities and challenges that come together with working efficiently with this new technology can widely vary between clinics, regions and countries. Lastly, it appears that smaller hospitals consider themselves in need of tools to support their decision-making in the RAR introduction phase. In collaboration with Hälsostaden and Region Skåne, we set out to develop a tool to support Ängelholm Hospital (ÄH) in their decision-making over a test-bed trial of RAR in their clinical setting. A tool that we coined the Co-Strategy Process (CSP), was developed based on identified needs related to this stage of the process, using a blend of interdisciplinary scientific methods. It integrates internal and external interdisciplinary expertise and includes four steps: Preparation, Knowledge Empowerment, Exchange & Development and Synthesis & Report. The current Master thesis presents the development and assessment of the CSP at ÄH. In the present context, it results in a new tool for supporting organizations implementing new technologies, optimized based on its application in a Swedish clinical setting. This tool aims at serving this introductory process, so that new technologies can be implemented meeting the needs of both the clinic and patients.e Rehab-robotic project in collaboration with Uppsala University, Basel University and ETH Zuric

Novel Y-Chromosome Long Non-Coding RNAs Expressed in Human Male CNS During Early Development

Global microarray gene expression analyses previously demonstrated differences in female and male embryos during neurodevelopment. In particular, before sexual maturation of the gonads, the differences seem to concentrate on the expression of genes encoded on the X- and Y-chromosomes. To investigate genome-wide differences in expression during this early developmental window, we combined high-resolution RNA sequencing with qPCR to analyze brain samples from human embryos during the first trimester of development. Our analysis was tailored for maximum sensitivity to discover Y-chromosome gene expression, but at the same time, it was underpowered to detect X-inactivation escapees. Using this approach, we found that 5 out of 13 expressed game to log pairs showed unbalanced gene dosage, and as a consequence, a male-biased expression. In addition, we found six novel non-annotated long non-coding RNAs on the Y-chromosome with conserved expression patterns in newborn chimpanzee. The tissue specific and time-restricted expression of these long non-coding RNAs strongly suggests important functions during central nervous system development in human males