Genomics goes chromosomal to explore the wheat genome

OBJECTIVES: The implant design and surface modification are independent conditions that can alter the implant bone response. The objective of this study is to compare the bone response to roughened tapered and cylindrical screw-type implants with and without hydroxyapatite (HA) surface coating in the femoral trabecular bone of rabbits. MATERIAL AND METHOD: Thirty-two implants (8 x 3.5 mm) consisting of four different types (eight implants in each group), that is, tapered implants, cylindrical implants, HA-coated tapered implants, and HA-coated cylindrical implants were installed in the femoral condyle of 16 rabbits. After 8 weeks of healing, the femoral condyles were retrieved and studied histologically. The bone-to-implant contact percentage was assessed and analyzed statistically. Results : The histomorphometric analysis revealed that the bone-to-implant contact (BIC) values seemed to be higher for HA-coated tapered implants (65.62 +/- 13.02) followed by cylindrical non-coated implants. All four types of implants showed wide distribution of BIC with no statistical significance between different types of implants. CONCLUSION: It can be concluded that under the current experimental conditions, implant design and surface composition had little effect on the bone-to-implant interface

Second-generation chromosome-specific BAC resources in wheat

In the societal and scientific discussions about the support for democracy and gender equality in the Arab Middle East, this study engages the triangular theory, which predicts that Islamic orientations influence gender equality attitudes and democracy negatively, and attitudes towards gender equality are also expected to lead to more democratic support, partly channelling the influence of Islam. This theory was tested on Arab Barometer data for seven countries, including three different dimensions of Islamic-religious identity: affiliation, piety, and political-Islamist attitudes. The analyses roughly back the triangular model, but for democratic support only the Islamist values seem important, partly working through economic gender equality attitudes. Attitudes towards women’s position in politics and education seem unrelated to democratic support. In addition, this study applies the gender and postcolonial concept of ‘othering’ to the triangular model. Theoretically it predicts that in the current neo-colonial era, anti-Western feelings might create more Islamic and less democracy and gender equal attitudes simultaneously, making Islam’s impact partly spurious. Empirically, this is modestly supported for the Islamist-democracy link only. However, anti-Western feelings do relate to gender equality, democratic support, and religious attitudes, and deserves more attention when studying democracy and gender equality in the Arab Middle East

The glucagon-like peptide-1 receptor as a potential treatment target in alcohol use disorder: evidence from human genetic association studies and a mouse model of alcohol dependence

The hormone glucagon-like peptide-1 (GLP-1) regulates appetite and food intake. GLP-1 receptor (GLP-1R) activation also attenuates the reinforcing properties of alcohol in rodents. The present translational study is based on four human genetic association studies and one preclinical study providing data that support the hypothesis that GLP-1R may have a role in the pathophysiology of alcohol use disorder (AUD). Case–control analysis (N=908) was performed on a sample of individuals enrolled in the National Institute on Alcohol Abuse and Alcoholism (NIAAA) intramural research program. The Study of Addiction: Genetics and Environment (SAGE) sample (N=3803) was used for confirmation purposes. Post hoc analyses were carried out on data from a human laboratory study of intravenous alcohol self-administration (IV-ASA;N=81) in social drinkers and from a functional magnetic resonance imaging study in alcohol-dependent individuals (N=22) subjected to a Monetary Incentive Delay task. In the preclinical study, a GLP-1R agonist was evaluated in a mouse model of alcohol dependence to demonstrate the role of GLP-1R for alcohol consumption. The previously reported functional allele 168Ser (rs6923761) was nominally associated with AUD (P=0.004) in the NIAAA sample, which was partially replicated in males of the SAGE sample (P=0.033). The 168Ser/Ser genotype was further associated with increased alcohol administration and breath alcohol measures in the IV-ASA experiment and with higher BOLD response in the right globus pallidus when receiving notification of outcome for high monetary reward. Finally, GLP-1R agonism significantly reduced alcohol consumption in a mouse model of alcohol dependence. These convergent findings suggest that the GLP-1R may be an attractive target for personalized pharmacotherapy treatment of AUD