THE MANAGEMENT OF PRIMARY DYSMENORRHOEA (KASHTARTAVA) - A PROSPECTIVE MULTICENTRIC OPEN OBSERVATIONAL STUDY

Objective: To evaluate the clinical usefulness of Rajahpravartini vati in the management of primary dysmenorrhoea (Kashtartava) and changes in the quality of life of the subjects. Study design: A multi-centric prospective single arm observational study. Setting and participants: 359 subjects aged between 16 - 35 years suffering from painful menstruation at least for three consecutive regular menstrual cycles were included in the study. Intervention: Rajahpravartini Vati a classical Ayurvedic formulation was administered 250 mg b.d. with lukewarm water for 90 days followed by subsequent 90 days without intervention. Outcome measures: The management of menstrual pain assessing by 10 points Visual Analogue Scale and improvement in the quality of life using SF-36 (RAND) questionnaire. Results: The mean VAS score of pain at baseline was 6.94±1.98, decreasing to 1.7±2.22 at 90th day which further decreased and maintained to 1.24±1.9 up to 180th day. Associated symptoms like nausea, vomiting, constipation, giddiness, breast tenderness, diarrhea, headache and fainting were completely relieved. The improvements of quality of life in 8 domains viz. pain, general health, physical functioning, social functioning, emotional wellbeing, energy/fatigue, limitation due to physical health and emotional problems at the end of 90th day of intervention was also significant (p<0.001) in comparison to baseline. No adverse event occurred during the treatment period. Conclusion: Rajahpravartini Vati has shown a positive role for the treatment of dysmenorrhoea and to improve the quality of life of the subjects

Versatile reactivity and theoretical evaluation of mono- and dinuclear oxidovanadium(V) compounds of aroylazines: electrogeneration of mixed-valence divanadium(IV,V) complexes

The solution behavior of structurally characterized [VVO(OEt)(L)] complexes, which transform into the corresponding divanadium(V,V) compounds [{VVO(L)}₂-μ-O], is reported. Upon controlled potential electrolysis, the corresponding [(L)V₂O₃(L)]⁻ mixed-valence species are obtained upon partial reduction of the [(VVOL)₂-μ-O] formed in solution. All compounds are characterized in the solid state and solution by spectroscopic techniques and DFT calculations. The formation of V₂O₃³⁺ species is confirmed by the observation of a 15- line pattern in the EPR spectra at room temperature

Physical properties of tender coconut

Not AvailableThe physical properties such as tender coconut size, weight, husk thickness, and husk moisture tender content play a vital role in the development of an efficient and ergonomic trimming machine. The important physical properties of tender coconuts of cultivars namely Kulasekaran Green Dwarf (KGD), Andaman Giant Tall (AGT), Ganga Bondam (GB), Malayan Orange Dwarf (MOD), and Chowghat Orange Dwarf (COD) were determined. The important properties including weight, diameter, height, husk thickness, husk moisture content, shell diameter, shell height, and shell thickness were high for nuts of AGT and low for COD nuts. The average bulk density, true density, and porosity of AGT were 332.47 kg m−3, 1,196.67 kg m−3, and 72.21%, respectively. The husk weight and volume of water of AGT were 87.77% and 12.39% high, respectively, compared with COD. In the correlation study, the coconut weight correlated positively (r = 0.791) with the diameter and vertical distance between the shell and the fruit base (r = 0.813). The principal component analysis suggested that the cultivars GB, KGD, and MOD have similar physical properties to COD and AGT. Thus, the present investigation documents crucial basic information to design an efficient and superior tender coconut trimming machine.ICA

Comparison of soil characteristics and carbon content of contrastingly different moist-mixed deciduous and evergreen mangrove forest in Odisha, India

The research associated the comparison of soil properties influencing organic carbon between forest of Chandaka Wildlife Sanctuary (CWS), Bhubaneswar and Bhitarkanika National Park (BNP), Rajnagar of Odisha. Soil samples were collected randomly from sampling plots (20 m × 50 m) and characterized by SEM and FT-IR, etc. The SEM micrographs analyze the aggregate-dominant fabric soil (Fine sand type) of CWS and matrix-dominated fabric soil (Clay loam type) of BNP. The FT-IR spectroscopy ensured the variant and prominent C-functional groups in both forest soils. The soil organic carbon of CWS (47.51 ± 2.16 Mg C/ha) and BNP (54.3 ± 3.0 Mg C/ha) directed through soil physico-chemical properties. The C/N ratio of CWS (51.3 ± 13.8) and BNP (21.6 ± 2.6) soil indicated the freshly added stable carbon compound availability at CWS. These results encourage study of soil organic carbon perspectives for sustainable forest conservation

Exploratory Study of the Relationship between the Levonorgestrel-Releasing Intrauterine System and Idiopathic

"Unconfirmed reports have linked the levonorgestrel-releasing intrauterine system (LNG-IUS aka Mirena), a long-acting contraceptive, to idiopathic intracranial hypertension (IIH). In this pilot study, we assessed signs and symptoms of IIH among a cohort of patients using LNG-IUS.

Highly Stable Hexacoordinated Nonoxidovanadium(IV) Complexes of Sterically Constrained Ligands: Syntheses, Structure, and Study of Antiproliferative and Insulin Mimetic Activity

Three highly stable, hexacoordinated nonoxidovanadium(IV), V-IV(L)(2), complexes (1-3) have been isolated and structurally characterized with tridentate aroylhydrazonates containing ONO donor atoms. All the complexes are stable in the open air in the solid state as well as in solution, a phenomenon rarely observed in nonoxidovanadium(IV) complexes. The complexes have good solubility in organic solvents, permitting electrochemical and various spectroscopic investigations. The existence of nonoxidovanadium(IV) complexes was confirmed by elemental analysis, ESI mass spectroscopy, cyclic voltammetry, EPR, and magnetic susceptibility measurements. X-ray crystallography showed the N3O3 donor set to define a trigonal prismatic geometry in each case. All the complexes show in vitro insulin mimetic activity against insulin responsive L6 myoblast cells, with complex 3 being the most potent, which is comparable to insulin at the complex concentration of 4 mu M, while the others have moderate insulin mimetic activity. In addition, the in vitro antiproliferative activity of complexes 1-3 against the He La cell line was assayed. The cytotoxicity of the complexes is affected by the various functional groups attached to the bezoylhydrazone derivative and 2 showed considerable antiproliferative activity compared to the most commonly used chemotherapeutic drugs

Chemistry of Monomeric and Dinuclear Non-Oxido Vanadium(IV) and Oxidovanadium(V) Aroylazine Complexes: Exploring Solution Behavior

A series of mononuclear non-oxido vanadium­(IV) [V^IV(L^1–4)₂] (<b>1</b>–<b>4</b>), oxidoethoxido vanadium­(V) [V^VO­(L^1–4)­(OEt)] (<b>5</b>–<b>8</b>), and dinuclear μ-oxidodioxidodivanadium­(V) [V^V₂O₃(L¹)₂] (<b>9</b>) complexes with tridentate aroylazine ligands are reported [H₂L¹ = 2-furoylazine of 2-hydroxy-1-acetonaphthone, H₂L² = 2-thiophenoylazine of 2-hydroxy-1-acetonaphthone, H₂L³ = 1-naphthoylazine of 2-hydroxy-1-acetonaphthone, H₂L⁴ = 3-hydroxy-2-naphthoylazine of 2-hydroxy-1-acetonaphthone]. The complexes are characterized by elemental analysis, by various spectroscopic techniques, and by single-crystal X-ray diffraction (for <b>2</b>, <b>3</b>, <b>5</b>, <b>6</b>, <b>8</b>, and <b>9</b>). The non-oxido V^IV complexes (<b>1</b>–<b>4</b>) are quite stable in open air as well as in solution, and DFT calculations allow predicting EPR and UV–vis spectra and the electronic structure. The solution behavior of the [V^VO­(L^1–4)­(OEt)] compounds (<b>5</b>–<b>8</b>) is studied confirming the formation of at least two different types of V^V species in solution, monomeric corresponding to <b>5</b>–<b>8</b>, and μ-oxidodioxidodivanadium [V^V₂O₃(L^1–4)₂] compounds. The μ-oxidodioxidodivanadium compound [V^V₂O₃(L¹)₂] (<b>9</b>), generated from the corresponding mononuclear complex [V^VO­(L¹)­(OEt)] (<b>5</b>), is characterized in solution and in the solid state. The single-crystal X-ray diffraction analyses of the non-oxido vanadium­(IV) compounds (<b>2</b> and <b>3</b>) show a N₂O₄ binding set and a trigonal prismatic geometry, and those of the V^VO complexes <b>5</b>, <b>6</b>, and <b>8</b> and the μ-oxidodioxidodivanadium­(V) (<b>9</b>) reveal that the metal center is in a distorted square pyramidal geometry with O₄N binding sets. For the μ-oxidodioxidodivanadium species in equilibrium with <b>5</b>–<b>8</b> in CH₂Cl₂, no mixed-valence complexes are detected by chronocoulometric and EPR studies. However, upon progressive transfer of two electrons, two distinct monomeric V^IVO species are detected and characterized by EPR spectroscopy and DFT calculations

Chemistry of Monomeric and Dinuclear Non-Oxido Vanadium(IV) and Oxidovanadium(V) Aroylazine Complexes: Exploring Solution Behavior

A series of mononuclear non-oxido vanadium­(IV) [V^IV(L^1–4)₂] (<b>1</b>–<b>4</b>), oxidoethoxido vanadium­(V) [V^VO­(L^1–4)­(OEt)] (<b>5</b>–<b>8</b>), and dinuclear μ-oxidodioxidodivanadium­(V) [V^V₂O₃(L¹)₂] (<b>9</b>) complexes with tridentate aroylazine ligands are reported [H₂L¹ = 2-furoylazine of 2-hydroxy-1-acetonaphthone, H₂L² = 2-thiophenoylazine of 2-hydroxy-1-acetonaphthone, H₂L³ = 1-naphthoylazine of 2-hydroxy-1-acetonaphthone, H₂L⁴ = 3-hydroxy-2-naphthoylazine of 2-hydroxy-1-acetonaphthone]. The complexes are characterized by elemental analysis, by various spectroscopic techniques, and by single-crystal X-ray diffraction (for <b>2</b>, <b>3</b>, <b>5</b>, <b>6</b>, <b>8</b>, and <b>9</b>). The non-oxido V^IV complexes (<b>1</b>–<b>4</b>) are quite stable in open air as well as in solution, and DFT calculations allow predicting EPR and UV–vis spectra and the electronic structure. The solution behavior of the [V^VO­(L^1–4)­(OEt)] compounds (<b>5</b>–<b>8</b>) is studied confirming the formation of at least two different types of V^V species in solution, monomeric corresponding to <b>5</b>–<b>8</b>, and μ-oxidodioxidodivanadium [V^V₂O₃(L^1–4)₂] compounds. The μ-oxidodioxidodivanadium compound [V^V₂O₃(L¹)₂] (<b>9</b>), generated from the corresponding mononuclear complex [V^VO­(L¹)­(OEt)] (<b>5</b>), is characterized in solution and in the solid state. The single-crystal X-ray diffraction analyses of the non-oxido vanadium­(IV) compounds (<b>2</b> and <b>3</b>) show a N₂O₄ binding set and a trigonal prismatic geometry, and those of the V^VO complexes <b>5</b>, <b>6</b>, and <b>8</b> and the μ-oxidodioxidodivanadium­(V) (<b>9</b>) reveal that the metal center is in a distorted square pyramidal geometry with O₄N binding sets. For the μ-oxidodioxidodivanadium species in equilibrium with <b>5</b>–<b>8</b> in CH₂Cl₂, no mixed-valence complexes are detected by chronocoulometric and EPR studies. However, upon progressive transfer of two electrons, two distinct monomeric V^IVO species are detected and characterized by EPR spectroscopy and DFT calculations