Long-term survival of olfactory sensory neurons after target depletion.

Life-long addition and elimination of neurons within the adult olfactory epithelium and olfactory bulb allows for adaptive structural responses to sensory experience, learning, and recovery after injury. The interdependence of the two structures is highlighted by the shortened life span of sensory neurons deprived of bulb contact, and has prompted the hypothesis that trophic cues from the bulb contribute to their survival. The specific identity and source of these signals remain unknown. To investigate the potential role of target neurons in this support, we employed a neurotoxic lesion to selectively remove them while preserving the remaining nerve projection pathway, and examined the dynamics of sensory neuron proliferation and survival. Pulse-labeling of progenitors with bromodeoxyuridine showed that, as with surgical bulb removal, increased apoptosis in the epithelium triggered accelerated production of new neurons after chemical depletion of target cells. Rather than undergoing premature death, a large subpopulation of these neurons survived long term. The combination of increased proliferation and extended survival resulted in essentially normal numbers of new sensory neurons surviving for as long as 5 weeks, with an accompanying restoration of olfactory marker protein expression. Changes in neurotrophic factor expression levels as measured by quantitative polymerase chain reaction (Q-PCR), and in bulb cell populations, including the addition of new neurons generated in the subventricular zone, were observed in the injured bulb. These data indicate that olfactory sensory neurons can adapt to reductions in their normal target field by obtaining sufficient support from remaining or alternative cell sources to survive and maintain their projections

Turbulent Convection in Stellar Interiors. I. Hydrodynamic Simulation

(Abridged) We describe the results of three-dimensional (3D) numerical simulations designed to study turbulent convection in the stellar interiors, and compare them to stellar mixing-length theory (MLT). Simulations in 2D are significantly different from 3D, both in terms of flow morphology and velocity amplitude. Convective mixing regions are better predicted using a [dynamic boundary condition] based on the bulk Richardson number than by purely local, static criteria like Schwarzschild or Ledoux. MLT gives a good description of the velocity scale and temperature gradient for a mixing length of $\sim 1.1 H_p$ for shell convection, however there are other important effects that it does not capture near boundaries. Convective "overshooting" is best described as an elastic response by the convective boundary, rather than ballistic penetration of the stable layers by turbulent eddies. We find that the rate at which material entrainment proceeds at the boundaries is consistent with analogous laboratory experiments as well as simulation and observation of terrestrial atmospheric mixing. In particular, the normalized entrainment rate E=$u_E/\sigma_H$, is well described by a power law dependence on the bulk Richardson number $Ri_B = \Delta b L/\sigma_H^2$ for the conditions studied, $20\lesssim Ri_B \lesssim 420$. We find $E = A Ri_B^{-n}$, with best fit values, $\log A = 0.027 \pm 0.38$, and $n = 1.05 \pm 0.21$. We discuss the applicability of these results to stellar evolution calculations

Let It Snow! Let It Snow! Let It Snow!

Photograph of John Gart; Illustration of home surrounded by snow with snowflakes falling from skyhttps://scholarsjunction.msstate.edu/cht-sheet-music/7948/thumbnail.jp

Come Out, Come Out, Wherever You Are

Photograph of Frank Sinatra as he appears in the film, Step Lively.https://scholarsjunction.msstate.edu/cht-sheet-music/2808/thumbnail.jp

Endocrine disruptors and abnormalities of pubertal development

Onset and development of puberty is regulated by the neuroendocrine system. Population-based studies worldwide have observed secular trends towards earlier puberty development. These changes are apparently caused by environmental factors such as improved socio-economic status, improved health care and nutrition. However, they may also partly result from endocrine-disrupting chemicals in the environment. Epidemiological studies have investigated the relationship between pubertal development and exposure to endocrine-disrupting chemicals (polychlorinated biphenyls, polybrominated biphenyls, 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane, phthalate esters, furans and the pesticide endosulfan). Associations with both perinatal and postnatal exposure have been reported. Studies in experimental animals support some of these findings and point to differential endocrine regulatory mechanisms linked to pubertal development acting in the perinatal and the pre-pubertal period. Pubertal development is naturally associated with growth and body composition. There is increasing evidence for a link between prenatal development and pubertal onset. In girls born small for gestational age (SGA), pubertal onset and age at menarche often are advanced, especially if there has been an extensive catch-up growth during the first months of life. In utero growth retardation may have multiple causes including exposure to xenobiotic substances as was suggested for some endocrine-disrupting chemicals. An abnormal perinatal environment of children born SGA may alter the endocrine status and the sensitivity of the receptors for endocrine and metabolic signalling that may have effects on maturation of brain and gonads. However, the causal pathways and the molecular mechanisms that may link the pubertal growth pattern of children born SGA, pubertal development and endocrine-disrupting chemicals need further study

I Believe

Photos of Frank Sinatra, Kathryn Grayson, Peter Lawford, and Jimmy Durante as they appear in the film It Happened in Brooklyn.https://scholarsjunction.msstate.edu/cht-sheet-music/3064/thumbnail.jp

The Things We Did Last Summer

Photograph of a womanhttps://scholarsjunction.msstate.edu/cht-sheet-music/10534/thumbnail.jp

Conchita, Marquita, Lolita, Pepita, Rosita, Juanita Lopez

Multiple photos and images from the film, Priorities on Parade.https://scholarsjunction.msstate.edu/cht-sheet-music/2795/thumbnail.jp