Predictors of Return to Work 12 Months After Solid Organ Transplantation: Results from the Swiss Transplant Cohort Study.

Background Return to work with or after a chronic disease is not a very well understood process, influenced by a variety of personal, professional, societal and medical factors. The aim of this study is to identify predictors for return to work 12 months after a solid organ transplant applying a bio-psycho-social model. Methods This study is based on patients included in the Swiss Transplant Cohort Study, a national prospective multicentre cohort, who underwent a first solid organ transplant (kidney, liver, heart, lung). Bio-psycho-social factors were tested and predictors of return to work identified using logistic regression models. Results Among the 636 patients included in the study, 49.8% (317) were employed 12 months post-transplant. The major predictor for returning to work 12 months posttransplant was pre-transplant employment status (OR 10.8). Accordingly, the population was stratified in employed and not employed pre-transplant groups. Age, self-perceived health (6 months post-transplant) and the transplanted organ were significantly associated with post-transplant employment status in both groups. Return to work was influenced by education, depression (6 month post-transplant) and waiting time in the employed pre-transplant group and by invalidity pension in the not employed pre-transplant group. Conclusion Employment status pre-transplant being highly associated with employment status post-transplant, the process promoting return to work should be started well before surgery. Biomedical, psychological and social factors must be taken into account to promote return to work in transplanted patients

The mediating role of mood in the relationship between perseverative cognition, sleep and subjective health complaints in music students.

Subjective health complaints (SHC) are frequent in musicians. These complaints may be particularly distressing in this population because they are performance relevant. This paper aims at testing a model positing that (a) perseverative cognition (PC) predicts sleep duration/quality, (b) sleep duration/quality predicts SHC and (c) mood is a mediator of these associations. Participants were 72 music students (mean age (SD): 22.7 (3.0) years), and the assessment period consisted of seven consecutive days, with a solo performance on the fifth day. Self-reported total sleep time (TST) and sleep quality were assessed 30 min after wake-up, and objective TST/sleep quality were assessed with an actigraphy watch. PC and mood were measured five times a day. Daily SHC were assessed at 9 p.m. PC did not significantly predict sleep duration/quality. Self-reported and objective TST and sleep quality were all significantly associated with SHC. Mood played a mediating role in each of these relationships with the exception of objective sleep quality. The tested model on the association among PC, sleep and SHC and the mediating role of mood received partial support, highlighting the importance of sleep and mood in the emergence of SHC among university music students

Identificação dos níveis séricos do fator de crescimento tipo insulina 1 em potros com osteocondrose

A osteocondrose é uma das doenças ortopédicas do desenvolvimento mais comuns em cavalos, e deve ser encarada como uma desordem multifatorial. Caracteriza-se por ser uma doença dinâmica, onde o processo de reparo inicia-se quase que imediatamente após a formação da lesão osteocondral. A intensidade e eficácia deste reparo são fortemente relacionados à idade, e estão associados a reposição dos componentes da matriz cartilagínea. Uma vez que o fator de crescimento tipo insulina-1 (IGF-1) age regulando o crescimento da cartilagem articular, este estudo objetivou descrever os níveis séricos de IGF-I, insulina e glicose em potros Puro Sangue Lusitano hígidos ou com osteocondrose, desde o nascimento até 18 meses de idade. Dos potros acompanhados, 76,08% apresentaram sinais radiográficos de osteocondrose com um mês de idade, porém somente 16,2% mantiveram as lesões aos 18 meses. As concentrações de IGF-1 alcançaram picos entre 14 e 16 meses, equivalente ao início da puberdade. As concentrações de IGF-1 nos potros com osteocondrose foram menores que potros sadios, aos 2 e 5 meses (P<0,05), e os de insulina aos 2 meses (P<0,05). Em criatórios com alta ocorrência de osteocondrose recomenda-se que as mensurações dos níveis séricos de IGF-1 e insulina ocorram durante os primeiros 6 meses de idade, para que haja tempo hábil de se estabelecer medidas profiláticas e de tratamento

Condição corporal ao parto e perfil metabólico de cabras alpinas no início da lactação Body condition and metabolic profile of Alpine goats at the onset of lactation

Objetivou-se avaliar a influência da condição corporal ao parto sobre alguns metabólitos sanguíneos em cabras no início da lactação. As cabras (68 no total) foram distribuídas em três grupos de acordo com o escore da condição corporal (ECC) ao parto: entre 1,00 e 2,75 (animais magros); entre 2,75 e 3,50 (condição corporal intermediária); e entre 3,50 e 5,00 (animais gordos). O experimento foi realizado nos primeiros 60 dias de lactação e as coletas de sangue, após o parto e semanalmente até a oitava semana de lactação. Foram feitas análises para determinação das concentrações de ácidos graxos não-esterificados (AGNE), beta-hidroxibutirato (BHBA), glicose, colesterol total e lipoproteína de alta densidade (HDL). As concentrações plasmáticas dos metabólitos não diferiram entre os grupos. As concentrações de AGNE, nos animais dos três grupos, ao parto e nas oito primeiras semanas de lactação, foram de 658,46 e 232,90 mg/dL, respectivamente, e os valores de BHBA ao parto, de 10,31 ± 3,0 mg/dL para os animais magros; 6,88 ± 0,9 mg/dL para os intermediários; e 4,21 ± 0,8 mg/dL para os animais gordos. Os valores de glicose ao parto foram de 112,54 ± 15,4 mg/dL para os animais magros; 90,93 ± 13,5 mg/dL para os animais intermediários; e 132,47 ± 26,7 mg/dL para os animais gordos. Os valores médios de colesterol total e de HDL nas oito primeiras semanas pós-parto foram de 109,01 ± 2,5 e 54,9 ± 1,39 mg/dL para os animais magros; 83,0 ± 21,7 e 56,0 ± 1,30 mg/dL para os intermediários; e 84,3 23,9 e 54,5 ± 1,93 mg/dL para os gordos. As alterações no metabolismo energético de cabras leiteiras de média produção diminuem, independentemente da condição corporal ao parto, quando fornecida dieta de alta qualidade e com altos níveis de energia.<br>An experiment was carried out to study the influence of the body condition score at birth on blood metabolites of goats in early lactation. Sixty-eight goats were placed in three groups according to the body condition score (BCS) at parturition: from 1.00 to 2.75 (thin animals); 2.75 and 3.50 (intermediate body condition) and from 3.50 to 5.00 (fat animals). The experimental was carried out in the first sixty days of lactation and blood sampling started after parturition at weekly intervals up to the eighth week of lactation. Analyses were made of the non-esterified fat acids (NEFA), beta-hydroxibutirate (BHBA), glucose, total cholesterol and high density lipoprotein (HDL). The plasma concentrations of the metabolites did not differ among the groups. The NEFA concentrations in the animals in the three groups at birth and in the first eight weeks of lactation were 658.46 and 232.90 mg/dL, respectively and the values of BHBA at birth were 10.31 ± 3.0 mg/dL for the thin animals, 6.88 ± 0.9 mg/dL for the intermediate animals and 4.21 ± 0.8 mg/dL for the fat animals. The glucose values at birth were 112.54 ± 15.4 mg/dL for the thin animals, 90.93 ± 13.5 mg/dL for the intermediate animals and 132.47 ± 26.7 mg/dL for the fat animals. The average of total cholesterol and HDL in the first eight weeks after birth were 109.01 ± 2.5; and 54.9 ± 1.39 mg/dL for the thin animals, 83.0 ± 21.7 and 56.0 ± 1.30 mg/dL for the intermediate animals and 84.3 ± 23.9 and 54.5 ± 1.93 mg/dL for the fat animals. The changes in the energy metabolism of dairy goats with medium production decreased, regardless of the body condition at birth, when supplied with high quality feed with high energy levels