Physiology of Aplysia Californica

Summaries of research papers on the Aplysia Californica are presented. Thirty three works are cited. Emphasis is on the nervous system organization of this animal

Report to the California Public Utilities Commission Regarding Ex Parte Communications and Related Practices

Part I contains the analysis of existing law. We review the statutes and regulations governing ex parte communications before the CPUC, examine corresponding laws of other jurisdictions, and compare the CPUC statutes and regulations with those of the other jurisdictions. In Part II we examine actual ex parte practices before the CPUC. Based on data obtained from notices filed on the Commission’s website by parties to rate-setting cases, we provide a quantitative characterization of the extent and nature of noticed ex parte communications over the past roughly 22 years. We then place ex parte communications within the context of the CPUC’s proceedings. Part III provides the results of an interview process we undertook to hear the experiences and opinions of people with a stake or an interest in CPUC decision-making, including representatives of regulated utilities, intervenor groups who generally (but not always) appear in CPUC rate-setting cases in opposition to the positions of utilities, companies and industry groups who generally oppose specific utilities’ positions, legislators and legislative staff, public critics of CPUC ex parte practices, CPUC staff (administrative law judges (ALJs), attorneys, and technical staff), and the CPUC Commissioners and their staffs. Then, in Part IV, we present our analysis of this information and our recommendations for changes to statutes, CPUC rules, and Commission practices

Exercise and Esr1 Control Mitochondrial Content and Function to Regulate Adiposity

Mechanisms that underlie adipose tissue remodeling to enhance metabolic health in response to exercise training remain inadequately understood. PURPOSE: We utilized mouse genetics and human GWAS to determine the impact of exercise training on mitochondrial DNA copy number, and interrogate the relationship between Esr1 and adipose tissue health. METHODS: We performed RNAseq on adipose tissue from 100 strains of inbred mice following exercise training and determined mitochondrial content by qPCR. We performed deep phenotyping of mice harboring conditional Esr1 overexpression selectively in adipose tissue. Adipose specific Esr1 overexpression and control mice were fed a high fat diet and placed in metabolic chambers to interrogate the effects of Esr1 on whole body metabolism. RESULTS: We determined that exercise training significantly increased adipose tissue mtDNA content in mouse and man and that increased mitochondrial content correlated with reduced adiposity. Adipocyte health was associated with increased expression of transcripts involved in mitochondrial cristae formation including OPA1, Polg1, and Dnm1l. Since Esr1 is a transcription factor negatively associated with adipose tissue mass, and since deletion of Esr1 disrupts mitochondrial function and reduces expression of Polg1, OPA1, and Dnm1l, we interrogated in impact of conditional Esr1 overexpression on mitochondrial function and adipose tissue health. Adipocyte-specific Esr1 overexpression increased expression of mitochondrial gene targets, increased mtDNA copy number and mitochondrial respiration, and enhanced whole body energy expenditure of animals challenged by high fat diet feeding. Adipocyte-specific Esr1 overexpression protected mice against HFD-induced obesity. CONCLUSION: Exercise promotes remodeling of adipose tissue mitochondria and is associated with fat mass reduction. Overexpression of Esr1 drives a similar adipose tissue remodeling and weight loss as exercise training, and protects against adipose tissue weight gain in the context of overnutrition. These data suggest that exercise responsive transcripts in adipose tissue can be selectively targeted to enhance weight loss and improve metabolic health

The plight of the nurse in community mental health centers

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/22708/1/0000263.pd

Bostonia: The Boston University Alumni Magazine. Volume 31

Founded in 1900, Bostonia magazine is Boston University's main alumni publication, which covers alumni and student life, as well as university activities, events, and programs

Beitrag zum Problem der heterosynaptischen Facilitation in Aplysia californica

1. Heterosynaptic facilitation (H.S.F.) of single neurons in the central nervous system of Aplysia can be repeated virtually indefinitely, provided sufficient time is allowed for recovery between the trials.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/47439/1/424_2004_Article_BF00362956.pd