Bathymetric Mapping and Sonar Imaging of Tufa at Green Lakes: Fayetteville, New York

The Fayetteville Green Lakes State Park, located in Fayetteville, New York, consists of two deep (48 m+), meromictic (non-mixing) lakes with unique limnological, bacterial, and chemical characteristics. These lakes, named Round Lake and its larger companion Green Lake, have been extensively studied for nearly 200 years because of their unique character. The lake water contains two distinct layers, the oxygen-rich mixolimnion and the anoxic monimolimnion divided by the chemocline (a chemical compositional boundary). Tufa deposits exist along the shorelines of both lakes at various depths and are a product of groundwater output into the lakes, as well as the lakes’ unique water chemistry and microbial communities. Here, we use sonar imaging techniques to produce updated bathymetric maps of Green and Round Lake, and provide the first detailed characterization of the near-shore environment using side-scanning sonar imagery to determine the locations and morphologies of tufa deposits. We also document shoreline debris specifically large tree trunks and branches which have fallen into the lake over time and are frequently encrusted. We identified fourteen locations of tufa ranging from large formations (10s of meters long) to small tufa heads (~1 m) in Green Lake. Our updated bathymetry and documentation of tufa locations and geometry expand on an extensive history of prior work, will aid future investigators by revealing lesser-known tufa localities, and will assist the Fayetteville Green Lakes State Park with monitoring and conservation efforts for this ecologically unique area

Microduplications of 16p11.2 are associated with schizophrenia

Recurrent microdeletions and microduplications of a 600-kb genomic region of chromosome 16p11.2 have been implicated in childhood-onset developmental disorders1,2,3. We report the association of 16p11.2 microduplications with schizophrenia in two large cohorts. The microduplication was detected in 12/1,906 (0.63%) cases and 1/3,971 (0.03%) controls (P = 1.2 × 10−5, OR = 25.8) from the initial cohort, and in 9/2,645 (0.34%) cases and 1/2,420 (0.04%) controls (P = 0.022, OR = 8.3) of the replication cohort. The 16p11.2 microduplication was associated with a 14.5-fold increased risk of schizophrenia (95% CI (3.3, 62)) in the combined sample. A meta-analysis of datasets for multiple psychiatric disorders showed a significant association of the microduplication with schizophrenia (P = 4.8 × 10−7), bipolar disorder (P = 0.017) and autism (P = 1.9 × 10−7). In contrast, the reciprocal microdeletion was associated only with autism and developmental disorders (P = 2.3 × 10−13). Head circumference was larger in patients with the microdeletion than in patients with the microduplication (P = 0.0007)

The multicomponent medication lymphomyosot improves the outcome of experimental lymphedema

Background: Secondary lymphedema is a life-long disease of painful tissue swelling that often follows axillary lymph node dissection to treat breast cancer. It is hypothesized that poor lymphatic regeneration across the obstructive scar tissue during the wound healing process may predispose the tissue to swell at a later date. Treatment for lymphedema remains suboptimal and is in most cases palliative. The purpose of this study was to evaluate the ability of Lymphomyosot to treat tissue swelling and promote lymphangiogenesis in experimental models of murine lymphedema. Methods: Experimental models of mouse lymphedema were injected with varied amounts of Lymphomyosot and saline as control. Measurements of tail swelling and wound closure were taken and compared amongst the groups. Three separate groups of mice were analyzed for lymphatic capillary migration, lymphatic vessel regeneration, and macrophage recruitment. Results: Lymphomyosot significantly reduced swelling and increased the rate of surgical wound closure. Lymphomyosot did not increase the migration of lymph capillaries in a mouse tail skin regeneration model or regeneration of lymph vessels following murine axillary lymph node dissection. Conclusions: Lymphomyosot may act through inflammatory and wound repair pathways to reduce experimental lymphedema. Its ability to regulate inflammation as well as assist in tissue repair and extracellular formation may allow for the production of a scar-free matrix bridge through which migrating cells and accumulated interstitial fluid can freely spread. © 2013, Mary Ann Liebert, Inc

A >200 ka U‐Th Based Chronology From Lacustrine Evaporites, Searles Lake, CA

Abstract Well‐dated lacustrine records are essential to establish the timing and drivers of regional hydroclimate change. Searles Basin, California, records the depositional history of a fluctuating saline‐alkaline lake in the terminal basin of the Owens River system draining the eastern Sierra Nevada. Here, we establish a U‐Th chronology for the ∼76‐m‐long SLAPP‐SLRS17 core collected in 2017 based on dating of evaporite minerals. Ninety‐eight dated samples comprising nine different minerals were evaluated based on stratigraphic, mineralogic, textural, chemical, and reproducibility criteria. After the application of these criteria, a total of 37 dated samples remained as constraints for the age model. A lack of dateable minerals between 145 and 110 ka left the age model unconstrained over the penultimate glacial termination (Termination II). We thus established a tie point between plant wax δD values in the core and a nearby speleothem δ18O record at the beginning of the Last Interglacial. We construct a Bayesian age model allowing stratigraphy to inform sedimentation rate inflections. We find that the >210 ka SLAPP‐SRLS17 record contains five major units that correspond with prior work. The new dating is broadly consistent with previous efforts but provides more precise age estimates and enables a detailed evaluation of evaporite depositional history. We also offer a substantial revision of the age of the Bottom Mud‐Mixed Layer contact, shifting it from ∼130 ka to 178 ± 3 ka. The new U‐Th chronology documents the timing of mud and salt layers and lays the foundation for climate reconstructions

Exercise for depression in older adults:a meta-analysis of randomized controlled trials adjusting for publication bias

To evaluate the antidepressant effects of exercise in older adults, using randomized controlled trial (RCT) data. We conducted a meta-analysis of exercise in older adults, addressing limitations of previous works. RCTs of exercise interventions in older people with depression ( 65 60 years) comparing exercise vs. control were eligible. A random-effects meta-analysis calculating the standardized mean difference (SMD) (95% confidence interval [95%CI]), meta-regressions, and trim, fill, and fail-safe number analyses were conducted. Eight RCTs were included, representing 138 participants in exercise arms and 129 controls. Exercise had a large and significant effect on depression (SMD = -0.90 [95%CI -0.29 to -1.51]), with a fail-safe number of 71 studies. Significant effects were found for 1) mixed aerobic and anaerobic interventions, 2) at moderate intensity, 3) that were group-based, 4) that utilized mixed supervised and unsupervised formats, and 5) in people without other clinical comorbidities. Adjusting for publication bias increased the beneficial effects of exercise in three subgroup analysis, suggesting that previous meta-analyses have underestimated the benefits of exercise due to publication bias. We advocate that exercise be considered as a routine component of the management of depression in older adults