HLA-G: expression in human keratinocytes in vitro and in human skin in vivo

Classical, polymorphic major histocompatibility complex class I molecules are expressed on most nucleated cells.They present peptides at the cell surface and, thus, enable the immune system to scan peptides for their antigenicity. The function of the other, nonclassical class I molecules in man is controversial. HLA-G which has been shown by transfection experiments to be expressed at the cell surface, is only transcribed in placental tissue and in the fetal eye.Therefore, a role of HLA-G in the control of rejection of the allogeneic fetus has been discussed. We found that HLA-G expression is induced in keratinocytes by culture in vitro. Three different alternative splicing products of HLA-G can be detected: a full length transcript, an mRNA lacking exon 3 and a transcript devoid of exon 3 and 4. Reverse transcription followed by polymerase chain reaction also revealed the presence of HLA-G mRNA in vivo in biopsies of either diseased or healthy skin

Microscopic study of neutrino trapping in hyperon stars

Employing the most recent parametrization of the baryon-baryon interaction of the Nijmegen group, we investigate, in the framework of the Brueckner--Bethe--Goldstone many-body theory at zero temperature, the influence of neutrino trapping on the composition, equation of state, and structure of neutron stars, relevant to describe the physical conditions of a neutron star immediately after birth (protoneutron star). We find that the presence of neutrinos changes significantly the composition of matter delaying the appearance of hyperons and making the equation of state stiffer. We explore the consequences of neutrino trapping on the early evolution of a neutron star and on the nature of the final compact remnant left by the supernova explosion.Comment: Astronomy & Astrophysics, 399, 687-693 (2003

IRFM T_eff calibrations for cluster and field giants in the Vilnius, Geneva, RI(C) and DDO photometric systems

Based on a large sample of disk and halo giant stars, for which accurate effective temperatures derived through the InfraRed Flux Method (IRFM) exist, a calibration of the temperature scale in the Vilnius, Geneva, RI(C) and DDO photometric systems is performed. We provide calibration formulae for the metallicity dependent T_eff vs color relations as well as grids of intrinsic colors and compare them with other calibrations. Photometry, atmospheric parameters and reddening corrections for the stars of the sample have been updated with respect to the original sources in order to reduce the dispersion of the fits. Application of our results to Arcturus leads to an effective temperature in excellent agreement with the value derived from its angular diameter and integrated flux. The effects of gravity on these T_eff vs color relations are also explored by taking into account our previous results for dwarf stars.Comment: Accepted for publication in A&

The Age Of Globular Clusters In Light Of Hipparcos: Resolving the Age Problem?

We review five independent techniques which are used to set the distance scale to globular clusters, including subdwarf main sequence fitting utilizing the recent Hipparcos parallax catalogue. These data together all indicate that globular clusters are farther away than previously believed, implying a reduction in age estimates. This new distance scale estimate is combined with a detailed numerical Monte Carlo study designed to assess the uncertainty associated with the theoretical age-turnoff luminosity relationship in order to estimate both the absolute age and uncertainty in age of the oldest globular clusters. Our best estimate for the mean age of the oldest globular clusters is now $11.5\pm 1.3$Gyr, with a one-sided, 95% confidence level lower limit of 9.5 Gyr. This represents a systematic shift of over 2 $\sigma$ compared to our earlier estimate, due completely to the new distance scale---which we emphasize is not just due to the Hipparcos data. This now provides a lower limit on the age of the universe which is consistent with either an open universe, or a flat, matter dominated universe (the latter requiring H_0 \le 67 \kmsmpc). Our new study also explicitly quantifies how remaining uncertainties in the distance scale and stellar evolution models translate into uncertainties in the derived globular cluster ages. Simple formulae are provided which can be used to update our age estimate as improved determinations for various quantities become available.Comment: 41 pages, including 10 eps figs, uses aaspp4.sty and flushrt.sty, submitted to Ap.J., revised to incorporate FULL Hipparcos catalogue dat

First High Contrast Imaging Using a Gaussian Aperture Pupil Mask

Placing a pupil mask with a gaussian aperture into the optical train of current telescopes represents a way to attain high contrast imaging that potentially improves contrast by orders of magnitude compared to current techniques. We present here the first observations ever using a gaussian aperture pupil mask (GAPM) on the Penn State near-IR Imager and Spectrograph (PIRIS) at the Mt. Wilson 100$^{\prime\prime}$ telescope. Two nearby stars were observed, $\epsilon$ Eridani and $\mu$ Her A. A faint companion was detected around $\mu$ Her A, confirming it as a proper motion companion. Furthermore, the observed H and K magnitudes of the companion were used to constrain its nature. No companions or faint structure were observed for $\epsilon$ Eridani. We found that our observations with the GAPM achieved contrast levels similar to our coronographic images, without blocking light from the central star. The mask's performance also nearly reached sensitivities reported for other ground based adaptive optics coronographs and deep HST images, but did not reach theoretically predicted contrast levels. We outline ways that could improve the performance of the GAPM by an order of magnitude or more.Comment: 8 pages, 4 figures, accepted by ApJ letter

A List of Bright Interferometric Calibrators measured at the ESO VLTI

In a previous publication (Richichi & Percheron 2005) we described a program of observations of candidate calibrator stars at the ESO Very Large Telescope Interferometer (VLTI), and presented the main results from a statistical point of view. In the present paper, we concentrate on establishing a new homogeneous group of bright interferometric calibrators, based entirely on publicly available K-band VLTI observations carried out with the VINCI instrument up to July 2004. For this, we have defined a number of selection criteria for the quality and volume of the observations, and we have accordingly selected a list of 17 primary and 47 secondary calibrators. We have developed an approach to a robust global fit for the angular diameters using the whole volume of quality-controlled data, largely independent of a priori assumptions. Our results have been compared with direct measurements, and indirect estimates based on spectrophotometric methods, and general agreement is found within the combined uncertainties. The stars in our list cover the range K=-2.9 to +3.0 mag in brightness, and 1.3 to 20.5 milliarcseconds in uniform-disk diameter. The relative accuracy of the angular diameter values is on average 0.4% and 2% for the primary and secondary calibrators respectively. Our calibrators are well suited for interferometric observations in the near-infrared on baselines between ~20m and ~200m, and their accuracy is superior, at least for the primary calibrators, to other similar catalogues. Therefore, the present list of calibrators has the potential to lead to significantly improved interferometric scientific results

Survey for Transiting Extrasolar Planets in Stellar Systems. II. Spectrophotometry and Metallicities of Open Clusters

We present metallicity estimates for seven open clusters based on spectrophotometric indices from moderate-resolution spectroscopy. Observations of field giants of known metallicity provide a correlation between the spectroscopic indices and the metallicity of open cluster giants. We use \chi^2 analysis to fit the relation of spectrophotometric indices to metallicity in field giants. The resulting function allows an estimate of the target-cluster giants' metallicities with an error in the method of \pm0.08 dex. We derive the following metallicities for the seven open clusters: NGC 1245, [m/H]=-0.14\pm0.04; NGC 2099, [m/H]=+0.05\pm0.05; NGC 2324, [m/H]=-0.06\pm0.04; NGC 2539, [m/H]=-0.04\pm0.03; NGC 2682 (M67), [m/H]=-0.05\pm0.02; NGC 6705, [m/H]=+0.14\pm0.08; NGC 6819, [m/H]=-0.07\pm0.12. These metallicity estimates will be useful in planning future extra-solar planet transit searches since planets may form more readily in metal-rich environments.Comment: 38 pages, including 12 figures. Accepted for publication in A

New abundance measurements in UKS 1927-177, a very metal-poor galaxy in the Local Group

We present new results from optical spectroscopy of the brightest Hii region in the dwarf irregular galaxy UKS 1927-177 in Sagittarius (SagDIG). From high signal-to-noise spectra, reddening-corrected line flux ratios have been measured with typical uncertainties of a few percent, from which the oxygen abundance is rediscussed, and new abundance estimates are derived for N and Ne. The O abundance in SagDIG, estimated with the empirical abundance indicator R23 and other methods, is in the range 12+log(O/H)=7.26 to 7.50. The fact that SagDIG is ~10 times closer than IZw18 makes it an ideal target to test the hypothesis of the existence of young galaxies in the present-day universe. Indeed, stellar photometry suggests that this galaxy may harbor a stellar population older than a few Gyr, and possibly an old stellar component as well. The case of SagDIG therefore supports the view that very low chemical abundances can be maintained throughout the life of a dwarf stellar system, even in the presence of multiple star formation episodes.Comment: 6 pages, 3 figures, accepted for publication in A&A, main journa

Radiative Corrections to γγ→ttˉ\gamma\gamma\to t \bar t in the Electroweak Standard Model

The cross-section for $\gamma\gamma\to t \bar t$ with arbitrary polarized photons is calculated within the electroweak Standard Model including the complete virtual and soft-photonic $O(\alpha)$ corrections. We present a detailed numerical discussion of the radiative corrections with particular emphasis on the purely weak corrections. These are usually of the order of 1--10\% for energies up to 1 TeV. For unpolarized or equally polarized photons they reach almost 10\% close to threshold. The large corrections cannot be traced back to a universal origin like the running of $\alpha$ or the $\rho$-parameter. Apart from the energy region around the Higgs resonance $(\gamma\gamma\to H^*\to t\bar t)$ the weak corrections are widely independent of the Higgs-boson mass.Comment: 22 pages, LaTeX (compressed, uuencoded), 20 figures as compressed uuencoded ps-files, complete ps-file available via anonymous ftp from ftp://ftp.physik.uni-wuerzburg.de/pub/preprint/WUE-ITP-95-017.p