2,256 research outputs found
Observing the emergence of chaos in a many-particle quantum system
Accessing the connection between classical chaos and quantum many-body
systems has been a long-standing experimental challenge. Here, we investigate
the onset of chaos in periodically driven two-component Bose-Einstein
condensates, whose small quantum uncertainties allow for exploring the phase
space with high resolution. By analyzing the uncertainties of time-evolved
many-body states, we find signatures of elliptic and hyperbolic periodic orbits
generated according to the Poincar\'e-Birkhoff theorem, and the formation of a
chaotic region at increasing driving strengths. The employed fluctuation
analysis allows for probing the phase-space structure by use of only short-time
quantum dynamics.Comment: 5+2 pages, 4 figure
Kann die 18F-FDG-PET/CT-Untersuchung die Panendoskopie zur Detektion von synchronen Zweitkarzinomen ersetzen?
Ziel der Arbeit war es, die Wertigkeit der 18F-FDG-PET/
CT-Untersuchung bezüglich synchroner Zweitkarzinome im Vergleich mit der Panendoskopie beim initialen Staging zu untersuchen. 311 Patienten wurden mit beiden Untersuchungsmethoden abgeklärt. Als Referenz galt die zytologische, histologische und/oder klinische oder radiologische Untersuchung. Die Prävalenz für synchrone Zweitkarzinome betrug mit der Panendoskopie 4,5%, während die Prävalenz mittels PET/ CT-Untersuchung 6,1% betrug. Die Sensitivität für die Panendoskopie betrug 74%, die Spezifität 99,7%, der positiv prädiktive Wert 93% und der negativ prädiktive Wert 98%. Die Sensitivität für die PET/CT-Untersuchung betrug 100%, die Spezifität 95,7% der positiv prädiktive Wert 59% und der negativ prädiktive Wert
100%. Die PET/CT-Untersuchung scheint der Panendoskopie
überlegen zu sein. Bei bezüglich synchroner Zweitkarzinome unauffälligem PET/CT kann die Panendoskopie auf die Endoskopie und Beurteilung des Primärtumors beschränkt werden kann. Aufgrund der hohen Kosten und der grossen Anzahl falsch positiver Resultate, welche durch das PET/CT generiert werden, empfehlen wir die Durchführung dieser Untersuchung nur bei fortgeschrittenen Tumoren mit der Frage nach Fernmetastasen. Die Panendoskopie bleibt weiterhin der Goldstandar
Lowest Order Constrained Variational Calculation of Structure Properties of Protoneutron Star
We calculate the structure properties of protoneutron star such as equation
of state, maximum mass, radius and temperature profile using the lowest order
constrained variational method. We show that the mass and radius of
protoneutron star decrease by decreasing both entropy and temperature. For the
protoneutron star, it is shown that the temperature is nearly constant in the
core and drops rapidly near the crust.Comment: 14 pages, 12 figures. Int. J. Theor. Phys. (2008) in pres
Hybrid protoneutron stars with the MIT bag model
We study the hadron-quark phase transition in the interior of protoneutron
stars. For the hadronic sector, we use a microscopic equation of state
involving nucleons and hyperons derived within the finite-temperature
Brueckner-Bethe-Goldstone many-body theory, with realistic two-body and
three-body forces. For the description of quark matter, we employ the MIT bag
model both with a constant and a density-dependent bag parameter. We calculate
the structure of protostars with the equation of state comprising both phases
and find maximum masses below 1.6 solar masses. Metastable heavy hybrid
protostars are not found.Comment: 12 pages, 9 figures submitted to Phys. Rev.
The value of 18F-FDG-PET/CT imaging for sinonasal malignant melanoma
The aim this study was to evaluate imaging findings using position emission tomography (PET) in combination with computed tomography (CT) and 18F-fluorodeoxyglucose (18F-FDG) in sinonasal malignant melanoma (SNMM) of the head and neck in a retrospective analysis of a consecutive cohort of patients. 18F-FDG-PET/CT examinations were performed for initial staging and compared with CT or magnetic resonance tomography (MRI), and 18F-FDG-PET alone. Medical records were reviewed retrospectively with regard to the location and the size of the tumor. Furthermore, locoregional and distant metastases with a consecutive change in therapy detected by 18F-FDG-PET/CT were assessed. Ten patients suffering from sinonasal malignant melanoma were staged and followed by 18F-FDG-PET/CT imaging. A total of 34 examinations were obtained. 18F-FDG-PET/CT depicted all primary tumors adequately. Aside from one cerebral metastasis all regional and distant metastases were truly identified by using this method. In summary, if available, 18F-FDG-PET/CT is a valuable imaging modality for staging and re-staging sinonasal malignant melanoma to evaluate expansion of the primary tumor, locoregional disease, and distant metastase
Tumour thrombus in the superior vena cava from anaplastic carcinoma of the thyroid: FDG-PET/CT imaging findings
The Age Of Globular Clusters In Light Of Hipparcos: Resolving the Age Problem?
We review five independent techniques which are used to set the distance
scale to globular clusters, including subdwarf main sequence fitting utilizing
the recent Hipparcos parallax catalogue. These data together all indicate that
globular clusters are farther away than previously believed, implying a
reduction in age estimates. This new distance scale estimate is combined with a
detailed numerical Monte Carlo study designed to assess the uncertainty
associated with the theoretical age-turnoff luminosity relationship in order to
estimate both the absolute age and uncertainty in age of the oldest globular
clusters. Our best estimate for the mean age of the oldest globular clusters is
now Gyr, with a one-sided, 95% confidence level lower limit of
9.5 Gyr. This represents a systematic shift of over 2 compared to our
earlier estimate, due completely to the new distance scale---which we emphasize
is not just due to the Hipparcos data. This now provides a lower limit on the
age of the universe which is consistent with either an open universe, or a
flat, matter dominated universe (the latter requiring H_0 \le 67 \kmsmpc).
Our new study also explicitly quantifies how remaining uncertainties in the
distance scale and stellar evolution models translate into uncertainties in the
derived globular cluster ages. Simple formulae are provided which can be used
to update our age estimate as improved determinations for various quantities
become available.Comment: 41 pages, including 10 eps figs, uses aaspp4.sty and flushrt.sty,
submitted to Ap.J., revised to incorporate FULL Hipparcos catalogue dat
Test-enhanced learning of clinical reasoning: a crossover randomised trial
CONTEXT: Clinical reasoning is an essential skill, the foundations of which should be acquired during undergraduate medical education. Student performance in clinical reasoning can be assessed using key feature examinations. However, within a paradigm of test-enhanced learning, such examinations may also be used to enhance long-term retention of procedural knowledge relevant to clinical reasoning. OBJECTIVES: This study tested the hypothesis that repeated testing with key feature questions is more effective than repeated case-based learning in fostering clinical reasoning. METHODS: In this randomised crossover trial, Year 4 medical students attended 10 weekly computer-based seminars during which patient case histories covering general medical conditions were displayed. The presentation format was switched between groups every week. In the control condition, students studied long case narratives. The intervention condition used the same content but augmented case presentation with a sequence of key feature questions. Using a within-subjects design, student performance on intervention and control items was assessed at 13 weeks (exit examination) and 9 months (retention test) after the first day of term. RESULTS: A total of 87 of 124 eligible students provided complete data for the longitudinal analysis (response rate: 70.2%). In the retention test, mean ± standard deviation student scores on intervention items were significantly higher than those on control items (56.0 ± 25.8% versus 48.8 ± 24.7%; p < 0.001). The results remained unchanged after accounting for exposure time in a linear regression analysis that also adjusted for sex and general student performance levels. CONCLUSIONS: This is the first study to demonstrate an effect of test-enhanced learning on clinical reasoning as assessed with key feature questions. In this randomised trial, repeated testing was more effective than repeated case-based learning alone. Curricular implementation of longitudinal key feature testing may considerably enhance student learning outcomes in relevant aspects of clinical medicine
An uncharged amine in the transition state of the ribosornal peptidyl transfer reaction.
The ribosome has an active site comprised of RNA that catalyzes peptide bond formation. To understand how RNA promotes this reaction requires a detailed understanding of the chemical transition state. Here, we report the Bronsted coefficient of the a-amino nucleophile with a series of puromycin derivatives. Both 50S subunit- and 70S ribosome-catalyzed reactions displayed linear free-energy relationships with slopes close to zero under conditions where chemistry is rate limiting. These results indicate that, at the transition state, the nucleophile is neutral in the ribosome-catalyzed reaction, in contrast to the substantial positive charge reported for typical uncatalyzed aminolysis reactions. This suggests that the ribosomal transition state involves deprotonation to a degree commensurate with nitrogen-carbon bond formation. Such a transition state is significantly different from that of uncatalyzed aminolysis reactions in solution
The Structure of Stellar Coronae in Active Binary Systems
A survey of 28 stars using EUV spectra has been conducted to establish the
structure of stellar coronae in active binary systems from the EMD, electron
densities, and scale sizes. Observations obtained by the EUVE during 9 years of
operation are included for the stars in the sample. EUVE data allow a
continuous EMD to be constructed in the range log T~5.6-7.4, using iron
emission lines. These data are complemented with IUE observations to model the
lower temperature range. Inspection of the EMD shows an outstanding narrow
enhancement, or ``bump'' peaking around log T~6.9 in 25 of the stars, defining
a fundamental coronal structure. The emission measure per unit stellar area
decreases with increasing orbital (or photometric) periods of the target stars;
stars in binaries generally have more material at coronal temperatures than
slowly rotating single stars. High electron densities (Ne>10^12 cm^-3) are
derived at ~10 MK for some targets, implying small emitting volumes. The
observations suggest the magnetic stellar coronae of these stars are consistent
with two basic classes of magnetic loops: solar-like loops with maximum
temperature around log T~6.3 and lower electron densities (Ne>10^9-10.5), and
hotter loops peaking around log T~6.9 with higher electron densities
(Ne>10^12). For the most active stars, material exists at much higher
temperatures (log T>6.9) as well. However, current ab initio stellar loop
models cannot reproduce such a configuration. Analysis of the light curves of
these systems reveals signatures of rotation of coronal material, as well as
apparent seasonal changes in the activity levels.Comment: 45 pages, 9 figures (with 20 eps files). Accepted for its publication
in ApJ
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