Control of fine-structure splitting and excitonic binding energies in selected individual InAs/GaAs quantum dots

A systematic study of the impact of annealing on the electronic properties of single InAs/GaAs quantum dots (QDs) is presented. Single QD cathodoluminescence spectra are recorded to trace the evolution of one and the same QD over several steps of annealing. A substantial reduction of the excitonic fine-structure splitting upon annealing is observed. In addition, the binding energies of different excitonic complexes change dramatically. The results are compared to model calculations within eight-band k.p theory and the configuration interaction method, suggesting a change of electron and hole wave function shape and relative position.Comment: 4 pages, 4 figure

Towards reliable diagnostics of prostate cancer via breath

Early detection of cancer is a key ingredient for saving many lives. Unfortunately, cancers of the urogenital system are difficult to detect at early stage. The existing noninvasive diagnostics of prostate cancer (PCa) suffer from low accuracy (< 70%) even at advanced stages. In an attempt to improve the accuracy, a small breath study of 63 volunteers representing three groups: (1) of 19 healthy, (2) 28 with PCa, (3) with 8 kidney cancer (KC) and 8 bladder cancer (BC) was performed. Ultrabroadband mid-infrared Fourier absorption spectroscopy revealed eight spectral ranges (SRs) that differentiate the groups. The resulting accuracies of supervised analyses exceeded 95% for four SRs in distinguishing (1) vs (2), three for (1) vs (3) and four SRs for (1) vs (2) + (3). The SRs were then attributed to volatile metabolites. Their origin and involvement in urogenital carcinogenesis are discussed

Emission Line Flickering from the Secondary Star in Cataclysmic Variables? A study of V3885 Sagitarii

Spectrophotometric observations of H-alpha and He I 6678 emission lines of the nova-like Cataclysmic Variable V3885 Sgr are presented and analyzed. The binary orbital period was determined as P = 0.20716071(22) days. Doppler Tomography was performed with both H-alpha and He I lines. Disc radial emissivity profiles were also computed. The tomography mapping of flickering sources was performed using the H-alpha line, from which we concluded that the flickering is not uniformly distributed on the disc. The observed tomogram of the flickering was compared with simulations, suggesting that the most intense flickering source in the H-alpha is not located in the accretion disc. It is proposed that the main line flickering source may be associated with the illuminated secondary star.Comment: 19 pages, 10 figures, 1 table. Accepted to be published on AJ. to donwload high resolution figures: http://www.astro.iag.usp.br/~fabiola/V3885_hires.pd

Is the observed high-frequency radio luminosity distribution of QSOs bimodal?

The distribution of QSO radio luminosities has long been debated in the literature. Some argue that it is a bimodal distribution, implying that there are two separate QSO populations (normally referred to as 'radio-loud' and 'radio-quiet'), while others claim it forms a more continuous distribution characteristic of a single population. We use deep observations at 20 GHz to investigate whether the distribution is bimodal at high radio frequencies. Carrying out this study at high radio frequencies has an advantage over previous studies as the radio emission comes predominantly from the core of the AGN, hence probes the most recent activity. Studies carried out at lower frequencies are dominated by the large scale lobes where the emission is built up over longer timescales (10^7-10^8 yrs), thereby confusing the sample. Our sample comprises 874 X-ray selected QSOs that were observed as part of the 6dF Galaxy Survey. Of these, 40% were detected down to a 3 sigma detection limit of 0.2-0.5 mJy. No evidence of bimodality is seen in either the 20 GHz luminosity distribution or in the distribution of the R_20 parameter: the ratio of the radio to optical luminosities traditionally used to classify objects as being either radio-loud or radio-quiet. Previous results have claimed that at low radio luminosities, star formation processes can dominate the radio emission observed in QSOs. We attempt to investigate these claims by stacking the undetected sources at 20 GHz and discuss the limitations in carrying out this analysis. However, if the radio emission was solely due to star formation processes, we calculate that this corresponds to star formation rates ranging from ~10 solar masses/yr to ~2300 solar masses/yr.Comment: 13 pages, 11 figures. Accepted for publication in Ap

Metabolic enzyme expression highlights a key role for MTHFD2 and the mitochondrial folate pathway in cancer

Metabolic remodeling is now widely regarded as a hallmark of cancer, but it is not clear whether individual metabolic strategies are frequently exploited by many tumours. Here we compare messenger RNA profiles of 1,454 metabolic enzymes across 1,981 tumours spanning 19 cancer types to identify enzymes that are consistently differentially expressed. Our meta-analysis recovers established targets of some of the most widely used chemotherapeutics, including dihydrofolate reductase, thymidylate synthase and ribonucleotide reductase, while also spotlighting new enzymes, such as the mitochondrial proline biosynthetic enzyme PYCR1. The highest scoring pathway is mitochondrial one-carbon metabolism and is centred on MTHFD2. MTHFD2 RNA and protein are markedly elevated in many cancers and correlated with poor survival in breast cancer. MTHFD2 is expressed in the developing embryo, but is absent in most healthy adult tissues, even those that are proliferating. Our study highlights the importance of mitochondrial compartmentalization of one-carbon metabolism in cancer and raises important therapeutic hypotheses

Infrared studies of the Be star X Per

Photometric and spectroscopic results are presented for the Be star X Per/HD 24534 from near-infrared monitoring in 2010-2011. The star is one of a sample of selected Be/X-ray binaries being monitored by us in the near-IR to study correlations between their X ray and near-IR behaviour. Comparison of the star's present near-IR magnitudes with earlier records shows the star to be currently in a prominently bright state with mean J, H, K magnitudes of 5.49, 5.33 and 5.06 respectively. The JHK spectra are dominated by emission lines of HeI and Paschen and Brackett lines of HI. Lines of OI 1.1287 and 1.3165 micron are also present and their relative strength indicates, since OI 1.1287 is stronger among the two lines, that Lyman beta fluorescence plays an important role in their excitation. Recombination analysis of the HI lines is done which shows that the Paschen and Brackett line strengths deviate considerably from case B predictions. These deviations are attributed to the lines being optically thick and this supposition is verified by calculating the line center optical depths predicted by recombination theory. Similar calculations indicate that the Pfund and Humphrey series lines should also be expected to be optically thick which is found to be consistent with observations reported in other studies. The spectral energy distribution of the star is constructed and shown to have an infrared excess. Based on the magnitude of the IR excess, which is modeled using a free-free contribution from the disc, the electron density in the disc is estimated and shown to be within the range of values expected in Be star discs.Comment: Accepted for publication in MNRAS, 7 pages, 6 figure

Zooming towards the Event Horizon - mm-VLBI today and tomorrow

Global VLBI imaging at millimeter and sub-millimeter wavelength overcomes the opacity barrier of synchrotron self-absorption in AGN and opens the direct view into sub-pc scale regions not accessible before. Since AGN variability is more pronounced at short millimeter wavelength, mm-VLBI can reveal structural changes in very early stages after outbursts. When combined with observations at longer wavelength, global 3mm and 1mm VLBI adds very detailed information. This helps to determine fundamental physical properties at the jet base, and in the vicinity of super-massive black holes at the center of AGN. Here we present new results from multi-frequency mm-VLBI imaging of OJ287 during a major outburst. We also report on a successful 1.3mm VLBI experiment with the APEX telescope in Chile. This observation sets a new record in angular resolution. It also opens the path towards future mm-VLBI with ALMA, which aims at the mapping of the black hole event horizon in nearby galaxies, and the study of the roots of jets in AGN.Comment: 6 pages, to appear in 11th European VLBI Network Symposium, ed. P. Charlot et al., Bordeaux (France), October 9-12, 201

Quantitative analysis of high-resolution, contrast-enhanced, cone-beam CT for the detection of intracranial in-stent hyperplasia

BACKGROUND: Intracranial in-stent hyperplasia is a stroke-associated complication that requires routine surveillance. OBJECTIVE: To compare the results of in vivo experiments to determine the accuracy and precision of in-stent hyperplasia measurements obtained with modified C-arm contrast-enhanced, cone-beam CT (CE-CBCT) imaging with those obtained by \u27gold standard\u27 histomorphometry. Additionally, to carry out clinical analyses comparing this CE-CBCT protocol with digital subtraction angiography (DSA). METHODS: A non-binned CE-CBCT protocol (VasoCT) was used that acquires x-ray images with a small field-of-view and applies a full-scale reconstruction algorithm providing high-resolution three-dimensional (3D) imaging with 100 microm isotropic voxels. In an vivo porcine model, VasoCT cross-sectional area measurements were compared with gold standard vessel histology. VasoCT and DSA were used to calculate in-stent stenosis in 23 imaging studies. RESULTS: Porcine VasoCT cross-sectional stent, lumen, and in-stent hyperplasia areas strongly correlated with histological measurements (r(2)=0.97, 0.93, 0.90; slope=1.14, 1.07, and 0.76, respectively; p\u3c0.0001). Clinical VasoCT percentage stenosis correlated well with DSA percentage stenosis (r(2)=0.84; slope=0.76), and the two techniques were free of consistent bias (Bland-Altman, bias=3.29%; 95% CI -14.75% to 21.33%). An illustrative clinical case demonstrated the advantages of VasoCT, including 3D capability and non-invasive IV contrast administration, for detection of in-stent hyperplasia. CONCLUSIONS: C-arm VasoCT is a high-resolution 3D capable imaging technique that has been validated in an animal model for measurement of in-stent tissue growth. Successful clinical implementation of the protocol was performed in a small case series. already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions