The First Faith-Based Movement: The Religious Roots of Social Progressivism in America (1880-1912) in Historical Perspective

This re-evaluation of the published writings of Richard T. Ely, Josiah Strong, and Jane Addams during the Progressive era (1880- 1912) explores the themes of religious idealism and nationalism that figured prominently in the early formulation of modern liberal reform ideology in the United States. A specific focus will be placed on tracing themes of the America’s millennial destiny and how they gradually evolved into prophesies of social transformation through the applied use of social science knowledge. Beyond merely satisfying historical curiosity, this inquiry provides a new perspective from which to consider the fierce clashes over social welfare policy which occurred in the twentieth century

Kank2 activates talin, reduces force transduction across integrins and induces central adhesion formation

International audienceIntegrin-based adhesions play critical roles in cell migration. Talin activates integrins and flexibly connects integrins to the actomyosin cytoskeleton, thereby serving as a 'molecular clutch' that transmits forces to the extracellular matrix to drive cell migration. Here we identify the evolutionarily conserved Kank protein family as novel components of focal adhesions (FAs). Kank proteins accumulate at the lateral border of FAs, which we term the FA belt, and in central sliding adhesions, where they directly bind the talin rod domain through the Kank amino-terminal (KN) motif and induce talin and integrin activation. In addition, Kank proteins diminish the talin-actomyosin linkage, which curbs force transmission across integrins, leading to reduced integrin-ligand bond strength, slippage between integrin and ligand, central adhesion formation and sliding, and reduced cell migration speed. Our data identify Kank proteins as talin activators that decrease the grip between the integrin-talin complex and actomyosin to regulate cell migration velocity