16 research outputs found
Rapid detection of A. pleuropneumoniae from clinical samples using recombinase polymerase amplification
- Author
- Publication venue
- 'Frontiers Media SA'
- Publication date
- 25/02/2022
- Field of study
Actinobacillus pleuropneumoniae (APP) is the causative agent of porcine pleuropneumonia, resulting in high economic impact worldwide. There are currently 19 known serovars of APP, with different ones being predominant in specific geographic regions. Outbreaks of pleuropneumonia, characterized by sudden respiratory difficulties and high mortality, can occur when infected pigs are brought into naïve herds, or by those carrying different serovars. Good biosecurity measures include regular diagnostic testing for surveillance purposes. Current gold standard diagnostic techniques lack sensitivity (bacterial culture), require expensive thermocycling machinery (PCR) and are time consuming (culture and PCR). Here we describe the development of an isothermal point-of-care diagnostic test - utilizing recombinase polymerase amplification (RPA) for the detection of APP, targeting the species-specific apxIVA gene. Our APP-RPA diagnostic test achieved a sensitivity of 10 copies/µL using a strain of APP serovar 8, which is the most prevalent serovar in the UK. Additionally, our APP-RPA assay achieved a clinical sensitivity and specificity of 84.3% and 100%, respectively, across 61 extracted clinical samples obtained from farms located in England and Portugal. Using a small subset (n = 14) of the lung tissue samples, we achieved a clinical sensitivity and specificity of 76.9% and 100%, respectively) using lung imprints made on FTA cards tested directly in the APP- RPA reaction. Our results demonstrate that our APP-RPA assay enables a suitable rapid and sensitive screening tool for this important veterinary pathogen
The A's, G's, C's, and T's of health disparities
- Author
- A Jemal
- AJ Schulz
- C Robbins
- C Stringer
- CA Haiman
- California Newsreel Vital Pictures
- CB Stringer
- Charles Rotimi
- CN Rotimi
- CW Yancy
- D Levy
- DA Wheeler
- DL Dries
- DV Exner
- E Check-Hayden
- E Pettersson
- Edward Ramos
- ER Mardis
- FE Grine
- I Cheng
- JS Witte
- KE Lohmueller
- M Ingman
- ML Freedman
- National Center for Health Statistics
- Office of Management and Budget
- OW Brawley
- P Carson
- P Forster
- PC Ng
- S Levy
- SA Tishkoff
- SB Liggett
- T Acharya
- T Kivisild
- TA Manolio
- TA Manolio
- The Beta-Blocker Evaluation of Survival Trial Investigators
- The International HapMap Consortium
- VL Roger
- VL Shavers
- World Health Organization. Advisory Committee on Health Research
- Publication venue
- BioMed Central
- Publication date
- 01/05/2009
- Field of study
In order to eliminate health disparities in the United States, more efforts are needed to address the breadth of social issues directly contributing to the healthy divide observed across racial and ethnic groups. Socioeconomic status, education, and the environment are intimately linked to health outcomes. However, with the tremendous advances in technology and increased investigation into human genetic variation, genomics is poised to play a valuable role in bolstering efforts to find new treatments and preventions for chronic conditions and diseases that disparately affect certain ethnic groups. Promising studies focused on understanding the genetic underpinnings of diseases such as prostate cancer or beta-blocker treatments for heart failure are illustrative of the positive contribution that genomics can have on improving minority health
Prognostic model to predict postoperative acute kidney injury in patients undergoing major gastrointestinal surgery based on a national prospective observational cohort study.
- Author
- Aamir A
- Abbas J
- Abbas N
- Abbott TEF
- Abdalla M
- Abdikadir H
- Abuhussein N
- Acquaah F
- Adamson R
- Adeleye O
- Adeogun A
- Adlan A
- Aftab R
- Afzal Z
- Agarwal M
- Aglan H
- Agnew CJF
- Agrawal R
- Ahern D
- Ahluwalia J
- Ahluwalia V
- Ahmad A
- Ahmad K
- Ahmed H
- Ahmed I
- Ahmed L
- Ahmed N
- Ahmed P
- Ainger E
- Ainsworth P
- Aishwarya G
- Ajibola-Taylor O
- Akhbari M
- Akhtar A
- Akhtar R
- Akpenyi O
- Al-Ausi M
- Al-Huneidi R
- Al-Khudairi R
- Al-Masri S
- Al-Mousawi A
- Al-Saadi N
- Alagappan A
- Alberts J
- Alfa-Wali M
- Ali A
- Ali B
- Ali I
- Ali M
- Ali Q
- Ali S
- Alturki N
- Alwandi A
- Amani L
- Amarnath T
- Amer M
- Amin H
- Amin MN
- Amoah R
- Amoah-Arko A
- Anandarajah C
- Ananthavarathan P
- Andah EJE
- Andrew K
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- Ani C
- Anilkumar A
- Anto N
- Anwar S
- Apperley H
- Appleton S
- Aquilina T
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- Arneill M
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- Arnold TJ
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- STARSurg Collaborative Writing Committee, Data analysis, Steering committee, Advisory group, Regional leads, Collaborators and validators
- STARSurg Collaborative Writing Committee, Data analysis, Steering committee, Advisory group, Regional leads, Collaborators and validators, Nepogodiev, D
- Stechman M
- Stewart D
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- Stoddart MT
- Stokes E
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- Strang S
- Stringer H
- Stringfellow TD
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- Subar D
- Subratty SM
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- Suresh R
- Suresh S
- Sureshkumar A
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- Yahaya AA
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- Zanichelli D
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- Zheleniakova T
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- Zornoza A
- Zubikarai G
- Zulkifli A
- Zuzarte L
- Publication venue
- 'Wiley'
- Publication date
- 18/05/2018
- Field of study
Background: Acute illness, existing co-morbidities and surgical stress response can all contribute to postoperative acute kidney injury (AKI) in patients undergoing major gastrointestinal surgery. The aim of this study was prospectively to develop a pragmatic prognostic model to stratify patients according to risk of developing AKI after major gastrointestinal surgery. Methods: This prospective multicentre cohort study included consecutive adults undergoing elective or emergency gastrointestinal resection, liver resection or stoma reversal in 2-week blocks over a continuous 3-month period. The primary outcome was the rate of AKI within 7 days of surgery. Bootstrap stability was used to select clinically plausible risk factors into the model. Internal model validation was carried out by bootstrap validation. Results: A total of 4544 patients were included across 173 centres in the UK and Ireland. The overall rate of AKI was 14·2 per cent (646 of 4544) and the 30-day mortality rate was 1·8 per cent (84 of 4544). Stage 1 AKI was significantly associated with 30-day mortality (unadjusted odds ratio 7·61, 95 per cent c.i. 4·49 to 12·90; P < 0·001), with increasing odds of death with each AKI stage. Six variables were selected for inclusion in the prognostic model: age, sex, ASA grade, preoperative estimated glomerular filtration rate, planned open surgery and preoperative use of either an angiotensin-converting enzyme inhibitor or an angiotensin receptor blocker. Internal validation demonstrated good model discrimination (c-statistic 0·65). Discussion: Following major gastrointestinal surgery, AKI occurred in one in seven patients. This preoperative prognostic model identified patients at high risk of postoperative AKI. Validation in an independent data set is required to ensure generalizability
Swept Under the Rug? A Historiography of Gender and Black Colleges
- Author
- Alexander William T
- Allen-Castellitto Anita
- Anderson Eric
- Anderson K
- Anderson Margaret L
- Aptheker Bettina
- Avery Vida
- Baham Eva
- Barry Keith
- Beamon Harry
- bell hooks
- bell hooks
- bell hooks
- Bell-Scott Patricia
- Bell-Scott Patricia
- Bell-Scott Patricia
- Bethel Leonard
- Blackwell Barbara
- Bond Horace Mann
- Bond Jean Carey
- Bowles Frank
- Bracey John
- Brazzell Johnetta Cross
- Brown Linda Beatrice
- Brown M Christopher
- Browning Jane E Smith
- Butchart Ronald E
- Cade Toni
- Campbell Clarice
- Carroll Constance
- Cash Gail
- Chancer Lynn
- Chapel Cynthia
- Chivers Walter
- Clary George
- Cole Johnnetta Betsch
- Collier-Thomas Bettye
- Collier-Thomas Bettye
- Collins Alicia C
- Collins Alicia C
- Collins Patricia Hill
- Collins Patricia Hill
- Collins Patricia Hill
- Collins Patricia Hill
- Comminey Shawn
- Crawford Vicki
- Cuthbert Marian
- Davis Angela Y
- Davis Lenwood
- Davis Leroy
- Dill Bonnie Thorton
- Drewry Henry
- Du Bois WEB
- Dyson Walter
- Edwards Ishmell
- Engs Robert
- Evans Stephanie Y
- Evans Stephanie Y
- Evans-Herring Cassandra
- Fancher Evelyn
- Favors Jelani
- Foster Terry
- Fox-Genovese Elizabeth
- Francis Valera T
- Frazier E Franklin
- Freeman Kassie
- Gallot Mildred
- Garrett R Thomas
- Gasman Marybeth
- Gasman Marybeth
- Gasman Marybeth
- Gasman Marybeth
- Gasman Marybeth
- Gibson De Lois
- Giddings Paula
- Giddings Paula
- Gilkes Cheryl Townsend
- Gilpin Patrick J
- Glenn Evelyn Nakano
- Graham Frances D
- Graham Frances D
- Gurin Patricia
- Guy-Sheftal Beverly
- Guy-Sheftal Beverly
- Hansen Joyce A
- Hansen Joyce A
- Harley Sharon
- Harper Shaun R
- Hill ST
- Hine Darlene Clark
- Hine Darlene Clark
- Hine Darlene Clark
- Hine Darlene Clark
- Hine Darlene Clark
- Hine Darlene Clark
- Holmes Dwight OW
- Hunter Wilma
- Hutcheson Philo A
- Ihle Elizabeth L
- Irving John
- Isaacs Barbara
- Jabs Albert
- Jackson Gretchen
- Jaffe Abram J
- James Joy
- Jenkins Clara
- Johnson Alandus
- Johnson Karen Ann
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- Keller FR
- Kittrell Flemmie
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- Marybeth Gasman
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- McCluskey Audrey T
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- McCluskey Audrey T
- McGinnis Frederick
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- McJamerson Jimmy
- McKinney Theophilus
- McKinny Richard I
- McMillian Joseph
- Morton Patricia
- Moses Yolanda
- Moynihan Daniel Patrick
- Muse Clifford
- Myers Lena Wright
- National Association of College Women
- Nidiffer Jana
- Noble Jeanne L
- O’Brien G
- Palmieri Patricia
- Parker Marjorie
- Parsons M
- Perkins Linda M
- Perkins Linda M
- Perkins Linda M
- Perkins Linda M
- Player Willa
- Poole H Randall
- Ramsey Berkley
- Read Florence
- Read Florence
- Richardson Frederick
- Roane Florence
- Robinson William
- Romelle Charlestine
- Rosenblum Karen
- Rothman Norman
- Rovaris Dereck
- Sanders Katrina
- Seymour Elaine
- Slowe Lucy Diggs
- Smith Valerie
- Solomon Barbara
- Spencer Chonita Robinson
- Sterling Dorothy
- Stringer Patricia S
- Sutton Virginia Ann
- Taliaferro Cecil
- Thompson Daniel C
- Thompson Kathleen
- Thurgood Marshall Fund
- Thurman Frances
- Vanlandingham Karen
- Venkatesan Madhavi
- Wadelington Charles Weldon
- Wallace Michelle
- Warren-Christian Christiane
- Washington Elsie
- Watkins William
- Watson Yolanda
- Watson-Moore Yolanda
- Williams Juan
- Williams Zachery
- Willie Charles
- Willie Charles V
- Wimbish Jerrold
- Wolters Raymond
- Woodson Carter G
- Woodson Carter G
- Woody Thomas
- Wright Earl
- Yellin Jean Fagan
- Young Jacqueline
- Publication venue
- 'American Educational Research Association (AERA)'
- Publication date
- Field of study
International Consensus Statement on Rhinology and Allergy: Rhinosinusitis
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- Abadie WM
- Abi Najm S
- Abigail P
- Abrahams JJ
- Abrass LJ
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- Abshirini H
- Abuzeid WM
- Abuzeid WM
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- Adam P
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- Agache I
- Aghamohammadi A
- Agius AM
- Agyeman AA
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- Ahn HJ
- Ahn JC
- Ahn SH
- Ahovuo‐Saloranta A
- Aitken M
- Ajaiyeoba A
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- American Academy of Pediatrics Steering Committee on Quality Improvement and Management (AAP SCQIM)
- Amin MR
- Amine M
- Amodu EJ
- Anamika A
- Anand V
- Anderson DE
- Anderson WC
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- Antunes MB
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- Anzai Y
- Anzić SA
- Aramani A
- Arden KE
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- Zielinska‐Blizniewska H
- Zou L
- Zuckerman JD
- Zurlo JJ
- Zuskin E
- Čulig J
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2021
- Field of study
Background: The 5 years since the publication of the first International Consensus Statement on Allergy and Rhinology: Rhinosinusitis (ICAR‐RS) has witnessed foundational progress in our understanding and treatment of rhinologic disease. These advances are reflected within the more than 40 new topics covered within the ICAR‐RS‐2021 as well as updates to the original 140 topics. This executive summary consolidates the evidence‐based findings of the document. Methods: ICAR‐RS presents over 180 topics in the forms of evidence‐based reviews with recommendations (EBRRs), evidence‐based reviews, and literature reviews. The highest grade structured recommendations of the EBRR sections are summarized in this executive summary. Results: ICAR‐RS‐2021 covers 22 topics regarding the medical management of RS, which are grade A/B and are presented in the executive summary. Additionally, 4 topics regarding the surgical management of RS are grade A/B and are presented in the executive summary. Finally, a comprehensive evidence‐based management algorithm is provided. Conclusion: This ICAR‐RS‐2021 executive summary provides a compilation of the evidence‐based recommendations for medical and surgical treatment of the most common forms of RS
Search for excited leptons in proton-proton collisions at s = 8 s=8 TeV
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- A. A. Ocampo Rios
- A. Abdulsalam
- A. Ackert
- A. Adair
- A. Adiguzel
- A. Agapitos
- A. Ahmad
- A. Aleksandrov
- A. Apresyan
- A. Apyan
- A. Askew
- A. Attikis
- A. Aubin
- A. Avetisyan
- A. B. Meyer
- A. Baden
- A. Barker
- A. Baskakov
- A. Baty
- A. Bean
- A. Belloni
- A. Belyaev
- A. Belyaev
- A. Benaglia
- A. Beretvas
- A. Bhardwaj
- A. Bocci
- A. Bodek
- A. Boletti
- A. Bonato
- A. Bornheim
- A. Borzou
- A. Braghieri
- A. Brinkerhoff
- A. Bundock
- A. Burgmeier
- A. Bylinkin
- A. Byszuk
- A. C. Benvenuti
- A. C. Marini
- A. C. Mignerey
- A. Cabrera
- A. Cakir
- A. Calamba
- A. Calderon
- A. Campbell
- A. Carnes
- A. Castaneda Hernandez
- A. Castro
- A. Caudron
- A. Chatterjee
- A. Christian
- A. Cimmino
- A. Colaleo
- A. Custódio
- A. Dabrowski
- A. David
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Identification of a novel antisense noncoding RNA, ALID, transcribed from the putative imprinting control region of marsupial IGF2R
- Author
- A Lewis
- A Thurston
- A Wutz
- AJ Pask
- AM Raizis
- CB Oudejans
- CH Tyndale-Biscoe
- DP Barlow
- DP Barlow
- E Ager
- F Santoro
- F Sleutels
- F Sleutels
- FM O’Sullivan
- G Braidotti
- G Smits
- Geoffrey Shaw
- IY Yotova
- JK Killian
- JM Stringer
- JM Stringer
- JM Stringer
- LC Li
- M Frommer
- Marilyn B. Renfree
- MB Renfree
- MB Renfree
- MB Renfree
- MB Renfree
- MH Braunschweig
- MJ O’Neill
- O Ogawa
- OW Smrzka
- PA Latos
- R Das
- R Lyle
- R Stöger
- S Suzuki
- S Suzuki
- S Suzuki
- S Suzuki
- S Suzuki
- Shunsuke Suzuki
- T Kaneko-Ishino
- T Nagano
- TA Hore
- VM Kalscheuer
- W Reik
- Y Kumaki
- Y Xu
- YQ Xu
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Traumatic dissections of the extracranial internal carotid artery
- Author
- Ajir F
- Alpert JN
- Bahram Mokri
- Batzdorf U
- Bickerstaff ER
- Bradac GB
- Cairns H
- Chandler WF
- David G. Piepgras
- Dragon R
- Ehrenfeld WK
- Fisher CM
- Fisher CM
- Fleming JFR
- French BN
- Friedman WA
- Fry RE
- Gee W
- Hart RG
- Hodge CJ
- Houser OW
- Huckman MS
- Lai MD
- Liliequist B
- Lloyd J
- Luken MG III
- McNeill DH
- Mokri B
- Mokri B
- New PFJ
- O. Wayne Houser
- Ojemann RG
- Ringel SP
- Scherman BM
- Stringer WL
- Tangchai P
- Verneuil M
- Vitek JJ
- West TET
- Yamada S
- Young PH
- Zelenock GB
- Publication venue
- 'Journal of Neurosurgery Publishing Group (JNSPG)'
- Publication date
- Field of study
Assessment of Competence in Pediatric Gastrointestinal Endoscopy
- Author
- A Chak
- A Darzi
- A Elvevi
- A Poerregaard
- AD Koch
- AK Shergill
- AM Leichtner
- AM Plooy
- AR Ende
- AV Haycock
- B Dunkin
- BJ Dunkin
- BJ Spier
- BR Parry
- Catharine M. Walsh
- CB Kromann
- CM Walsh
- CM Walsh
- CP Winckel
- CPM Vleuten Van der
- D Armstrong
- D Mohankumar
- DG Lerner
- DJ Desilets
- DM Israel
- E Hassall
- EGG Verdaasdonk
- G Dafnis
- G Page
- G Regehr
- GE Miller
- GM Eisen
- J Cohen
- J Lightdale
- J-J Rethans
- JD Beard
- JD Mason
- JE Jorgensen
- JJ Felsher
- JR Frank
- JR Lightdale
- KH Thakkar
- KL Obstein
- M Dillon
- MC Vassiliou
- MD Stringer
- MJB Govaerts
- MN Appleyard
- MR Chassin
- O Cass
- OW Cass
- OW Cass
- P Hicks
- P Mamula
- R Fayez
- R Sidhu
- RA McConnell
- RE Sedlack
- RE Sedlack
- RE Sedlack
- RE Sedlack
- RE Sedlack
- RK Reznick
- RL Kneebone
- RM Epstein
- S Bar-Meir
- S Forget
- S Singh
- SG Shah
- SK Klasko
- SM Case
- SR Swing
- ST Ward
- T Mahmood
- TP Grantcharov
- V Wass
- VJ Shute
- VN Palter
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Regulation of eIF-2 Activity and Initiation of Protein Synthesis in Mammalian Cells
- Author
- A Barrieux
- A Das
- A Das
- A Dasgupta
- A Dasgupta
- A Dasgupta
- A Majumdar
- A Majumdar
- A Majumdar
- A Zilberstein
- AB Henderson
- B Chatterjee
- B Lebleu
- B Safer
- BV Treadwell
- C Haro de
- C Haro de
- C Haro de
- D Levin
- DH Levin
- DH Levin
- E Ehrenfeld
- EA Stringer
- G Kohler
- G Kohler
- G Kramer
- G Kramer
- GA Howard
- GAM Hofstad Van der
- GC Sen
- GL Dettman
- H Amesz
- I Harbitz
- J Siekierka
- JJ Osterhout
- JR Lenz
- M Gross
- M Gross
- M Gross
- M Gross
- M Rabinovitz
- MA Lloyd
- MB Methews
- MH Schreier
- MH Schreier
- MJ Clemens
- MJ Clemens
- N.S. Kosower
- NK Gupta
- OW Odom
- P Ghosh-Dastidar
- P Ghosh-Dastidar
- P Pinphanichakran
- PE Ranu
- PJ Farrell
- R Benne
- R Benne
- R Benne
- R Benne
- R Kaempfer
- R Kaempfer
- R Kaempfer
- RM Sundari
- RO Ralston
- RO Ralston
- RS Ranu
- RS Ranu
- RS Ranu
- RS Ranu
- RS Ranu
- S Reynolds
- SA Austin
- T Hunt
- T MacRae
- T Staehelin
- V Ernst
- VG Malathi
- VG Malathia
- W Roth
- WK Roberts
- YC Chen
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1982
- Field of study