23 research outputs found
Quantum Chemical AM1 Treatment of the Circumscribing Algorithm: Fullerene Growth Mechanism
Alkylaminopyridine-Modified Aluminum Aminoterephthalate Metal-Organic Frameworks As Components of Reactive Self-Detoxifying Materials
Aluminum aminoterephthalate MOF particulate materials
(NH<sub>2</sub>-MIL-101(Al) and NH<sub>2</sub>-MIL-53(Al)), studied
here as components of self-detoxifying surfaces, retained their reactivity
following their covalent attachment to protective surfaces utilizing
a newly developed strategy in which the MOF particles were deposited
on a reactive adhesive composed of polyisobutylene/toluene diisocyanate
(PIB/TDI) blends. Following MOF attachment and curing, the MOF primary
amino groups were functionalized with highly nucleophilic 4-methylaminopyridine
(4-MAP) by disuccinimidyl suberate-activated conjugation. The resulting
MOF-4-MAP modified PIB/TDI elastomeric films were mechanically flexible
and capable of degrading diisopropyl fluorophosphate (DFP), a chemical
threat simulant
Clinical and microbiological characteristics of severe Streptococcus pyogenes disease in Europe
Clinical and microbiological characteristics of severe Streptococcus pyogenes disease in Europe
Clinical and microbiological characteristics of severe Streptococcus pyogenes disease in Europe
In an attempt to compare the epidemiology of severe Streptococcus pyogenes infection within Europe, prospective data were collected through the Strep-EURO program. Surveillance for severe cases of S. pyogenes infection diagnosed during 2003 and 2004 was undertaken in 11 countries across Europe by using a standardized case definition and questionnaire. Patient data as well as bacterial isolates were collected and characterized by T and M/emm typing, and selected strains were analyzed for the presence of superantigen genes. Data were analyzed to compare the clinical and microbiological patterns of the infections across the participating countries. A total of 4,353 isolates were collected from 5,521 cases with severe S. pyogenes infections who were identified. A wide diversity of M/emm types (n = 104) was found among the S. pyogenes clinical isolates, but the M/emm type distribution varied broadly between participating countries. The 10 most predominant M/emm types were M/emm type 1 (M/emm1), M/emm28, M/emm3, M/emm89, M/emm87, M/emm12, M/emm4, M/emm83, M/emm81, and M/emm5, in descending order. A correlation was found between some specific disease manifestations, the age of the patients, and the emm types. Although streptococcal toxic shock syndrome and necrotizing fasciitis were caused by a large number of types, they were particularly associated with M/emm1 and M/emm3. The emm types included in the 26-valent vaccine under development were generally well represented in the present material; 16 of the vaccine types accounted for 69% of isolates. The Strep-EURO collaborative program has contributed to enhancement of the knowledge of the spread of invasive disease caused by S. pyogenes within Europe and encourages future surveillance by the notification of cases and the characterization of strains, which are important for vaccination strategies and other health care issues. Copyright © 2009, American Society for Microbiology. All Rights Reserved