Simulation of reflow-based heat transfer on different thermocouple constructions

In this paper, the heating during reflow soldering for different thermocouple constructions is modelled in order to reveal possible deviations originated from thermocouple constructions. K-type (Chromel-Alumel) thermocouples are investigated from the aspect of various physical constructions. The physical dimensions were measured with optical microscopy for several types of thermocouples. Based on those results, CAD geometry was realized for finite element analysis. The temperature dependence of the welded hot-spot was investigated in time domain with different uninsulated wire lengths close to the hot-spot, insulation- and hot-spot radiuses. The effect of the various heat transfer coefficient values was also analyzed. The simulation results were also compared with validation measurements performed with a K-type thermocouple in a Vapour Phase Soldering (VPS) chamber

Modelling of temperature distribution along PCB thickness in different substrates during reflow

In this paper, analytical modelling of heat distribution along the thickness of different printed circuit board (PCB) substrates is presented according to the 1 D heat transient conduction problem. This paper aims to reveal differences between the substrates and the geometry configurations and elaborate on further application of explicit modelling

Heat transfer aspects of condensation during vapour phase soldering on aligned PCB-based surfaces

The paper aims to present an investigation on heat transfer in a vapour phase soldering (VPS) oven, focusing on the differences of horizontally and vertically aligned Printed Circuit Board (PCB) surfaces. The investigation can help develop a better understanding of the process and provide information for future modelling of the process

Wetting of Different Lead Free Solder Alloys During Vapour Phase Soldering

In this paper the wetting properties of lead free solder alloys were investigated on different printed circuit boards (PCB) during Vapour Phase Soldering (VPS), which is an alternative reflow method with non-conventional heat-transfer mechanism. Our motivation was to investigate the phenomenon on PCBs with different thermal capacities, with different heating power and with different solder alloys. The aim of the research is to clear the relations between the thermal capacities of the) PCBs and the spreading of the solder on it, and to investigate the effect of the change of heating power on the solder spreading during VPS. In addition, the impact of the VPS on different solder alloys and the performance of the VPS machine in the wake of the contact angle quality was investigated. Findings show that the thickness of the PCB is not affecting significantly the spread and the wetting. The composition of the alloy, the paste, and the heating power points to observable differences in the final result

In vitro and in vivo mRNA delivery using lipid-enveloped pHresponsive polymer nanoparticles

Biodegradable core−shell structured nanoparticles with a poly(β-amino ester) (PBAE) core enveloped by a phospholipid bilayer shell were developed for in vivo mRNA delivery with a view toward delivery of mRNA-based vaccines. The pH-responsive PBAE component was chosen to promote endosome disruption, while the lipid surface layer was selected to minimize toxicity of the polycation core. Messenger RNA was efficiently adsorbed via electrostatic interactions onto the surface of these net positively charged nanoparticles. In vitro, mRNA-loaded particle uptake by dendritic cells led to mRNA delivery into the cytosol with low cytotoxicity, followed by translation of the encoded protein in these difficult-to-transfect cells at a frequency of 30%. Particles loaded with mRNA administered intranasally (i.n.) in mice led to the expression of the reporter protein luciferase in vivo as soon as 6 h after administration, a time point when naked mRNA given i.n. showed no expression. At later time points, luciferase expression was detected in naked mRNA-treated mice, but this group showed a wide variation in levels of transfection, compared to particle-treated mice. This system may thus be promising for noninvasive delivery of mRNA-based vaccines.United States. Dept. of Defense (Institute for Soldier Nanotechnology, contract W911NF-07-D-0004)Ragon Institute of MGH, MIT and HarvardSingapore. Agency for Science, Technology and ResearchHoward Hughes Medical Institute (Investigator