TT2013 meeting report: the transgenic technology meeting visits Asia for the first time

The 11th Transgenic Technology meeting was held in Guangzhou, China on 25th–27th February 2013. Over 300 scientists and students from round the world gathered to hear the latest developments in the technologies underpinning the creation of transgenic and knockout animals and their application to biological sciences in areas such as the modeling human diseases and biotechnology. As well as informative presentations from leading researchers in the field, an excellent selection of short talks selected from abstracts and posters, attendees were also treated to an inspiring talk from Allan Bradley who was awarded the 9th International Society of Transgenic Technologies Prize for outstanding contributions to the field of transgenic technologies

The Renormalization Group for Flag Manifolds

The renormalization group equations for a class of non--relativistic quantum $\sigma$--models targeted on flag manifolds are given. These models emerge in a continuum limit of generalized Heisenberg antiferromagnets. The case of the ${SU(3)\over U(1)\times U(1)}$ manifold is studied in greater detail. We show that at zero temperature there is a fixed point of the RG transformations in $(2+\varepsilon )$--dimensions where the theory becomes relativistic. We study the linearized RG transformations in the vicinity of this fixed point and show that half of the couplings are irrelevant. We also show that at this fixed point there is an enlargement of the global isometries of the target manifold. We construct a discrete non--abelian enlargement of this kind.Comment: 22 page

Continuous Local Symmetry in Ising-type Models

A class of generalized Ising models is examined with a view to extracting a low energy sector comprising Dirac fermions coupled to Yang-Mills vectors. The main feature of this approach is a set of gap equations, covariant with respect to one of the $4$-dimensional crystallographic space groups.Comment: 7 pages, latex, IC/94/2

Shaping Future Generations

Due to the extent and variety of research available on the topic of child-targeted advertising, it was determined that an appraisal of the current state of the situation was necessary in order to determine the best course of action. After summarizing the history of children’s advertising and considering the arguments on both sides of the debate – from the children’s advocates and the advertising industry – the previously recommended solutions were evaluated in the paper. Each of these possible solutions were considered, and led to the proposal of a best solution. Supported by research, the best solution advocated a joint effort between the children’s advocates, parents and the advertising industry that emphasized education over government restriction

Sex workers perspectives on strategies to reduce sexual exploitation and HIV risk: a qualitative study in Tijuana, Mexico.

Globally, female sex workers are a population at greatly elevated risk of HIV infection, and the reasons for and context of sex industry involvement have key implications for HIV risk and prevention. Evidence suggests that experiences of sexual exploitation (i.e., forced/coerced sex exchange) contribute to health-related harms. However, public health interventions that address HIV vulnerability and sexual exploitation are lacking. Therefore, the objective of this study was to elicit recommendations for interventions to prevent sexual exploitation and reduce HIV risk from current female sex workers with a history of sexual exploitation or youth sex work. From 2010-2011, we conducted in-depth interviews with sex workers (n = 31) in Tijuana, Mexico who reported having previously experienced sexual exploitation or youth sex work. Participants recommended that interventions aim to (1) reduce susceptibility to sexual exploitation by providing social support and peer-based education; (2) mitigate harms by improving access to HIV prevention resources and psychological support, and reducing gender-based violence; and (3) provide opportunities to exit the sex industry via vocational supports and improved access to effective drug treatment. Structural interventions incorporating these strategies are recommended to reduce susceptibility to sexual exploitation and enhance capacities to prevent HIV infection among marginalized women and girls in Mexico and across international settings

Loss of strumpellin in the melanocytic lineage impairs the WASH Complex but does not affect coat colour

The five-subunit WASH complex generates actin networks that participate in endocytic trafficking, migration and invasion in various cell types. Loss of one of the two subunits WASH or strumpellin in mice is lethal, but little is known about their role in mammals in vivo. We explored the role of strumpellin, which has previously been linked to hereditary spastic paraplegia, in the mouse melanocytic lineage. Strumpellin knockout in melanocytes revealed abnormal endocytic vesicle morphology but no impairment of migration in vitro or in vivo and no change in coat colour. Unexpectedly, WASH and filamentous actin could still localize to vesicles in the absence of strumpellin, although the shape and size of vesicles was altered. Blue native PAGE revealed the presence of two distinct WASH complexes, even in strumpellin knockout cells, revealing that the WASH complex can assemble and localize to endocytic compartments in cells in the absence of strumpellin

Dissociative Autoionization in (1+2)-photon Above Threshold Excitation of H2 Molecules

We have theoretically studied the effect of dissociative autoionization on the photoelectron energy spectrum in (1+2)-photon above threshold ionization(ATI) of H2 molecules. We have considered excitation from the ground state X-singlet-Sigma-g+(v=0,j) to the doubly excited autoionizing states of singlet-Sigma-u+ and singlet-Pi-u+ symmetry, via the intermediate resonant B-singlet-Sigma-u+(v=5,j) states. We have shown that the photoelectron energy spectrum is oscillatory in nature and shows three distinct peaks above the photoelectron energy 0.7 eV. This feature has been observed in a recent experiment by Rottke et al, J. Phys. B, Vol. 30, p-4049 (1997).Comment: 11 pages and 4 figure

On the determination of the dilaton-antisymmetric tensor couplings in supergravity theories

A new approach is provided to determine the dilaton--antisymmetric tensor coupling in a supergravity theory by considering the static supersymmetric field configuration around a super extended object, which is consistently formulated in a curved superspace. By this, the corresponding SUSY transformation rules can also be determined for vanishing fermionic fields as well as bosonic fields other than those in the determined coupling. Therefore, we can, in turn, use this determined part of the supergravity theory to study all the related vacuum-like solutions. We have determined the dilaton--antisymmetric tensor couplings, in which each of the antisymmetric tensors is a singlet of the automorphism group of the corresponding superalgebra, for every supergravity multiplet. This actually happens only for $N \leq 2$ supergravity theories, which agrees completely with the spin-content analysis and the classified $N \leq 2$ super $p$-branes, therefore giving more support to the existence of the fundamental Type II $p$-branes. A prediction is made of the $D = 9, N = 2$ supergravity which has not yet been written down so far.Comment: 23 pages, harvmac, CERN-TH.6691/9