2,853 research outputs found
THE ESTERASES OF MOUSE BLOOD *
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/73169/1/j.1749-6632.1961.tb35579.x.pd
The dispersive self-dual Einstein equations and the Toda lattice
The Boyer-Finley equation, or -Toda equation is both a reduction
of the self-dual Einstein equations and the dispersionlesslimit of the
-Toda lattice equation. This suggests that there should be a dispersive
version of the self-dual Einstein equation which both contains the Toda lattice
equation and whose dispersionless limit is the familiar self-dual Einstein
equation. Such a system is studied in this paper. The results are achieved by
using a deformation, based on an associative -product, of the algebra
used in the study of the undeformed, or dispersionless,
equations.Comment: 11 pages, LaTeX. To appear: J. Phys.
Logarithmic deformations of the rational superpotential/Landau-Ginzburg construction of solutions of the WDVV equations
The superpotential in the Landau-Ginzburg construction of solutions to the Witten-Dijkgraaf-Verlinde-Verlinde (or WDVV) equations is modified to include logarithmic terms. This results in deformations - quadratic in the deformation parameters- of the normal prepotential solutions of the WDVV equations. Such solutions satisfy various pseudo-quasi-homogeneity conditions, on assigning a notional weight to the deformation parameters. These solutions originate in the so-called `water-bag' reductions of the dispersionless KP hierarchy. This construction includes, as a special case, deformations which are polynomial in the flat coordinates, resulting in a new class of polynomial solutions of the WDVV equations
Gate Coupling to Nanoscale Electronics
The realization of single-molecule electronic devices, in which a
nanometer-scale molecule is connected to macroscopic leads, requires the
reproducible production of highly ordered nanoscale gaps in which a molecule of
interest is electrostatically coupled to nearby gate electrodes. Understanding
how the molecule-gate coupling depends on key parameters is crucial for the
development of high-performance devices. Here we directly address this,
presenting two- and three-dimensional finite-element electrostatic simulations
of the electrode geometries formed using emerging fabrication techniques. We
quantify the gate coupling intrinsic to these devices, exploring the roles of
parameters believed to be relevant to such devices. These include the thickness
and nature of the dielectric used, and the gate screening due to different
device geometries. On the single-molecule (~1nm) scale, we find that device
geometry plays a greater role in the gate coupling than the dielectric constant
or the thickness of the insulator. Compared to the typical uniform nanogap
electrode geometry envisioned, we find that non-uniform tapered electrodes
yield a significant three orders of magnitude improvement in gate coupling. We
also find that in the tapered geometry the polarizability of a molecular
channel works to enhance the gate coupling
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Mean and extreme precipitation over European river basins better simulated in a 25km AGCM
Limited spatial resolution is one of the factors that may hamper applications of global climate models (GCMs), in particular over Europe with its complex coastline and orography. In this study, the representation of European mean and extreme precipitation is evaluated in simulations with an atmospheric GCM (AGCM) at different resolutions between about 135 and 25km grid spacing in the mid-latitudes. The continent-wide root-mean-square error in mean precipitation in the 25km model is about 25% smaller than in the 135km model in winter. Clear improvements are also seen in autumn and spring, whereas the model's sensitivity to resolution is very small in summer. Extreme precipitation is evaluated by estimating generalised extreme value distributions (GEVs) of daily precipitation aggregated over river basins whose surface area is greater than 50000km2. GEV location and scale parameters are measures of the typical magnitude and of the interannual variability of extremes, respectively. Median model biases in both these parameters are around 10% in summer and around 20% in the other seasons. For some river basins, however, these biases can be much larger and take values between 50% and 100%. Extreme precipitation is better simulated in the 25km model, especially during autumn when the median GEV parameter biases are more than halved, and in the North European Plains, from the Loire in the west to the Vistula in the east. A sensitivity experiment is conducted showing that these resolution sensitivities in both mean and extreme precipitation are in many areas primarily due to the increase in resolution of the model orography. The findings of this study illustrate the improved capability of a global high-resolution model in simulating European mean and extreme precipitation
Effective temperatures in a simple model of non-equilibrium, non-Markovian dynamics
The concept of effective temperatures in nonequilibrium systems is studied
within an exactly solvable model of non-Markovian diffusion. The system is
coupled to two heat baths which are kept at different temperatures: one
('fast') bath associated with an uncorrelated Gaussian noise and a second
('slow') bath with an exponential memory kernel. Various definitions of
effective temperatures proposed in the literature are evaluated and compared.
The range of validity of these definitions is discussed. It is shown in
particular, that the effective temperature defined from the
fluctuation-dissipation relation mirrors the temperature of the slow bath in
parameter regions corresponding to a separation of time scales. On the
contrary, quasi-static and thermodynamic definitions of an effective
temperature are found to display the temperature of the fast bath in most
parameter regions
High-sensitivity troponin I concentrations are a marker of an advanced hypertrophic response and adverse outcomes in patients with aortic stenosis
Aims:
High-sensitivity cardiac troponin I (cTnI) assays hold promise in detecting the transition from hypertrophy to heart failure in aortic stenosis. We sought to investigate the mechanism for troponin release in patients with aortic stenosis and whether plasma cTnI concentrations are associated with long-term outcome.
Methods and results:
Plasma cTnI concentrations were measured in two patient cohorts using a high-sensitivity assay. First, in the Mechanism Cohort, 122 patients with aortic stenosis (median age 71, 67% male, aortic valve area 1.0 ± 0.4 cm2) underwent cardiovascular magnetic resonance and echocardiography to assess left ventricular (LV) myocardial mass, function, and fibrosis. The indexed LV mass and measures of replacement fibrosis (late gadolinium enhancement) were associated with cTnI concentrations independent of age, sex, coronary artery disease, aortic stenosis severity, and diastolic function. In the separate Outcome Cohort, 131 patients originally recruited into the Scottish Aortic Stenosis and Lipid Lowering Trial, Impact of REgression (SALTIRE) study, had long-term follow-up for the occurrence of aortic valve replacement (AVR) and cardiovascular deaths. Over a median follow-up of 10.6 years (1178 patient-years), 24 patients died from a cardiovascular cause and 60 patients had an AVR. Plasma cTnI concentrations were associated with AVR or cardiovascular death HR 1.77 (95% CI, 1.22 to 2.55) independent of age, sex, systolic ejection fraction, and aortic stenosis severity.
Conclusions:
In patients with aortic stenosis, plasma cTnI concentration is associated with advanced hypertrophy and replacement myocardial fibrosis as well as AVR or cardiovascular death
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Development of the Surface Urban Energy and Water balance Scheme (SUEWS) for cold climate cities
The Surface Urban Energy and Water Balance Scheme (SUEWS) is developed to include snow. The processes addressed include accumulation of snow on the different urban surface types: snow albedo and density aging, snow melting and re-freezing of meltwater. Individual model parameters are assessed and independently evaluated using long-term observations in the two cold climate cities of Helsinki and Montreal. Eddy covariance sensible and latent heat fluxes and snow depth observations are available for two sites in Montreal and one in Helsinki. Surface runoff from two catchments (24 and 45 ha) in Helsinki and snow properties (albedo and density) from two sites in Montreal are also analysed. As multiple observation sites with different land-cover characteristics are available in both cities, model development is conducted independent of evaluation.
The developed model simulates snowmelt related runoff well (within 19% and 3% for the two catchments in Helsinki when there is snow on the ground), with the springtime peak estimated correctly. However, the observed runoff peaks tend to be smoother than the simulated ones, likely due to the water holding capacity of the catchments and the missing time lag between the catchment and the observation point in the model. For all three sites the model simulates the timing of the snow accumulation and melt events well, but underestimates the total snow depth by 18–20% in Helsinki and 29–33% in Montreal. The model is able to reproduce the diurnal pattern of net radiation and turbulent fluxes of sensible and latent heat during cold snow, melting snow and snow-free periods. The largest model uncertainties are related to the timing of the melting period and the parameterization of the snowmelt. The results show that the enhanced model can simulate correctly the exchange of energy and water in cold climate cities at sites with varying surface cover
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Warming effects on the urban hydrology in cold climate regions
While approximately 338 million people in the Northern hemisphere live in regions that are regularly snow covered in winter, there is little hydro-climatologic knowledge in the cities impacted by snow. Using observations and modelling we have evaluated the energy and water exchanges of four cities that are exposed to wintertime snow. We show that the presence of snow critically changes the impact that city design has on the local-scale hydrology and climate. After snow melt, the cities return to being strongly controlled by the proportion of built and vegetated surfaces. However in winter, the presence of snow masks the influence of the built and vegetated fractions. We show how inter-year variability of wintertime temperature can modify this effect of snow. With increasing temperatures, these cities could be pushed towards very different partitioning between runoff and evapotranspiration. We derive the dependency of wintertime runoff on this warming effect in combination with the effect of urban densification.Peer reviewe
Hypercomplex Integrable Systems
In this paper we study hypercomplex manifolds in four dimensions. Rather than
using an approach based on differential forms, we develop a dual approach using
vector fields. The condition on these vector fields may then be interpreted as
Lax equations, exhibiting the integrability properties of such manifolds. A
number of different field equations for such hypercomplex manifolds are
derived, one of which is in Cauchy-Kovaleskaya form which enables a formal
general solution to be given. Various other properties of the field equations
and their solutions are studied, such as their symmetry properties and the
associated hierarchy of conservation laws.Comment: Latex file, 19 page
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