Thyroid Function Within the Reference Range and the Risk of Stroke: An Individual Participant Data Analysis.

The currently applied reference ranges for thyroid function are under debate. Despite evidence that thyroid function within the reference range is related with several cardiovascular disorders, its association with the risk of stroke has not been evaluated previously. We identified studies through a systematic literature search and the Thyroid Studies Collaboration, a collaboration of prospective cohort studies. Studies measuring baseline TSH, free T4, and stroke outcomes were included, and we collected individual participant data from each study, including thyroid function measurements and incident all stroke (combined fatal and nonfatal) and fatal stroke. The applied reference range for TSH levels was between 0.45 and 4.49 mIU/L. We collected individual participant data on 43 598 adults with TSH within the reference range from 17 cohorts, with a median follow-up of 11.6 years (interquartile range 5.1-13.9), including 449 908 person-years. Age- and sex-adjusted pooled hazard ratio for TSH was 0.78 (95% confidence interval [CI] 0.65-0.95 across the reference range of TSH) for all stroke and 0.83 (95% CI 0.62-1.09) for fatal stroke. For the free T4 analyses, the hazard ratio was 1.08 (95% CI 0.99-1.15 per SD increase) for all stroke and 1.10 (95% CI 1.04-1.19) for fatal stroke. This was independent of cardiovascular risk factors including systolic blood pressure, total cholesterol, smoking, and prevalent diabetes. Higher levels of TSH within the reference range may decrease the risk of stroke, highlighting the need for further research focusing on the clinical consequences associated with differences within the reference range of thyroid function

Serum magnesium and calcium levels in relation to ischemic stroke : Mendelian randomization study

ObjectiveTo determine whether serum magnesium and calcium concentrations are causally associated with ischemic stroke or any of its subtypes using the mendelian randomization approach.MethodsAnalyses were conducted using summary statistics data for 13 single-nucleotide polymorphisms robustly associated with serum magnesium (n = 6) or serum calcium (n = 7) concentrations. The corresponding data for ischemic stroke were obtained from the MEGASTROKE consortium (34,217 cases and 404,630 noncases).ResultsIn standard mendelian randomization analysis, the odds ratios for each 0.1 mmol/L (about 1 SD) increase in genetically predicted serum magnesium concentrations were 0.78 (95% confidence interval [CI] 0.69-0.89; p = 1.3 7 10-4) for all ischemic stroke, 0.63 (95% CI 0.50-0.80; p = 1.6 7 10-4) for cardioembolic stroke, and 0.60 (95% CI 0.44-0.82; p = 0.001) for large artery stroke; there was no association with small vessel stroke (odds ratio 0.90, 95% CI 0.67-1.20; p = 0.46). Only the association with cardioembolic stroke was robust in sensitivity analyses. There was no association of genetically predicted serum calcium concentrations with all ischemic stroke (per 0.5 mg/dL [about 1 SD] increase in serum calcium: odds ratio 1.03, 95% CI 0.88-1.21) or with any subtype.ConclusionsThis study found that genetically higher serum magnesium concentrations are associated with a reduced risk of cardioembolic stroke but found no significant association of genetically higher serum calcium concentrations with any ischemic stroke subtype

Novel genetic loci associated with hippocampal volume

The hippocampal formation is a brain structure integrally involved in episodic memory, spatial navigation, cognition and stress responsiveness. Structural abnormalities in hippocampal volume and shape are found in several common neuropsychiatric disorders. To identify the genetic underpinnings of hippocampal structure here we perform a genome-wide association study (GWAS) of 33,536 individuals and discover six independent loci significantly associated with hippocampal volume, four of them novel. Of the novel loci, three lie within genes (ASTN2, DPP4 and MAST4) and one is found 200 kb upstream of SHH. A hippocampal subfield analysis shows that a locus within the MSRB3 gene shows evidence of a localized effect along the dentate gyrus, subiculum, CA1 and fissure. Further, we show that genetic variants associated with decreased hippocampal volume are also associated with increased risk for Alzheimer's disease (rg =-0.155). Our findings suggest novel biological pathways through which human genetic variation influences hippocampal volume and risk for neuropsychiatric illness

Hindsight from InSight: what science coud have been don with a simpler mission?

The InSight mission was very successful at producing high quality seismic data to investigate the deep interior of Mars, delivering new estimates of the core size, the first value of the seismicity level and many other results. At the same time, the deployment of a high quality seismometer (very broadband, VBB) shaped the mission profile and required a dedicated robot arm. Future missions to Mars may want to carry a more robust short period seismometer (SP) to monitor the seismicity of the planet or investigate specific questions without shaping the whole mission around the instrument. We therefore investigated, which science results of the InSight mission could have been obtained with a significantly reduced effort

The marsquake catalogue from InSight, sols 0-1011

The InSight mission (Interior Exploration using Seismic Investigations, Geodesy and Heat Transport) has been collecting high-quality seismic data from Mars since February 2019, shortly after its landing. The Marsquake Service (MQS) is the team responsible for the prompt review of all seismic data recorded by the InSight's seismometer (SEIS), marsquake event detection, and curating seismicity catalogues. Until sol 1011 (end of September 2021), MQS have identified 951 marsquakes that we interpret to occur at regional and teleseismic distances, and 1062 very short duration events that are most likely generated by local thermal stresses nearby the SEIS package. Here, we summarize the seismic data collected until sol 1011, version 9 of the InSight seismicity catalogue. We focus on the significant seismicity that occurred after sol 478, the end date of version 3, the last catalogue described in a dedicated paper. In this new period, almost a full Martian year of new data has been collected, allowing us to observe seasonal variations in seismicity that are largely driven by strong changes in atmospheric noise that couples into the seismic signal. Further, the largest, closest and most distant events have been identified, and the number of fully located events has increased from 3 to 7. In addition to the new seismicity, we document improvements in the catalogue that include the adoption of InSight-calibrated Martian models and magnitude scales, the inclusion of additional seismic body-wave phases, and first focal mechanism solutions for three of the regional marsquakes at distances ∼30°