999 research outputs found
Speech and language difficulties in children with and without a family history of dyslexia
Comorbidity between SLI and dyslexia is well documented. Researchers have variously argued that dyslexia is a separate disorder from SLI, or that children with dyslexia show a subset of the difficulties shown in SLI. This study examines these hypotheses by assessing whether family history of dyslexia and speech and language difficulties are separable risk factors for literacy difficulties. Forty-six children with a family risk of dyslexia (FRD) and 36 children receiving speech therapy (SLT) were compared to 128 typically developing children. A substantial number (41.3%) of the children with FRD had received SLT. The nature of their difficulties did not differ in severity or form from those shown by the other children in SLT. However, both SLT and FRD were independent risk factors in predicting reading difficulties both concurrently and 6 months later. It is argued that the results are best explained in terms of Pennington's (2006) multiple deficits model
Evaluation of underground virtual environment training: Is a mining simulation or conventional power point more effective?
UNSW’s Schools of Mining Engineering and Psychology have jointly developed high-fidelity simulations for training in the coal mining industry aimed at improving safety. These simulations have capitalised on advanced technology to move beyond replications of traditional class-room training and to implement best, evidence-based instructional practices. The present paper describes controlled experiments conducted as an initial, rigorous evaluation of the simulations by testing one small component. Specifically, a 3-D simulation of a coal mine was compared to a 2-D slide-based presentation in the acquisition, retention and transfer of a standardised operating procedure. Novices were trained to re-start an exhaust fan and were subsequently given a multiple-choice test immediately after training and then again after a retention interval of one week or more. In Experiment 1, training was conducted using the mining simulator (Group Sim) versus class-room slide presentations (Group PP).To maintain the participants’ active attention, each step of the procedure was followed by a question and feedback. Experiment 2 included a third condition in which participants in the mining simulator were asked to collaborate in generating answers to the in-training questions (Group Sim+). Two weeks after the retention test in Experiment 2, the top five participants in Groups Sim+ and PP provided a hands-on demonstration of the exhaust-fan procedure. Across experiments, training in the simulator tended to yield better test scores than the class-room training, particularly in the practical, hands-on test. The positive effect of the mine simulation on acquisition, retention, and transfer of the procedure provides a foundation for further simulation-based modules, which can replicated across mine sites and provide consistent training that does not depend on the individual trainer. This replication and consistency will decrease the cost of development and ownership to a small fraction of the cost of mining
Learning organisations: A literature review and critique
Approved for Public Release - UnclassifiedA literature review on the Learning Organisation field was conducted, examining the dominant assumptions and creating a solid foundation for the practical application of the learning organisation concept to the Australian Army. In order to examine the literature's dominant assumptions, we asked the following questions: (i) What are the various meanings attributed to learning organisations?; (ii) What sorts of learnings are privileged within the literature?; (iii) What are the key characteristics or "building blocks" that make up a learning organisation? We discovered that the learning organisation construct represents an evolution from bureaucratic and performance-based organisational form to innovative and flexible organisations. In surveying the literature, other factors found to impact on learning organisations included cognitive, social, cultural, technological and structural elements. For example, learning organisations apply increasingly sophisticated understanding of knowledge and personnel management to best exploit their social, intellectual and knowledge capital. In contrast, some factors are not adequately explored in the literature; for example, the significance of power relations, hierarchy and authority on learning within and by organisations has not been fully elucidated. There is an increasing number of studies investigating the direct impact of developing a learner-centric approach on organisational outcomes; the number of studies linking learning to improved organisational performance is growing. There are real, significant and measureable benefits of developing the learning capabilities of an organisation.Steven Talbot, Christina Stothard, Maya Drobnjak and Denise McDowal
Elimination of Schistosomiasis Transmission in Zanzibar: Baseline Findings before the Onset of a Randomized Intervention Trial.
Gaining and sustaining control of schistosomiasis and, whenever feasible, achieving local elimination are the year 2020 targets set by the World Health Organization. In Zanzibar, various institutions and stakeholders have joined forces to eliminate urogenital schistosomiasis within 5 years. We report baseline findings before the onset of a randomized intervention trial designed to assess the differential impact of community-based praziquantel administration, snail control, and behavior change interventions. In early 2012, a baseline parasitological survey was conducted in ∼20,000 people from 90 communities in Unguja and Pemba. Risk factors for schistosomiasis were assessed by administering a questionnaire to adults. In selected communities, local knowledge about schistosomiasis transmission and prevention was determined in focus group discussions and in-depths interviews. Intermediate host snails were collected and examined for shedding of cercariae. The baseline Schistosoma haematobium prevalence in school children and adults was 4.3% (range: 0-19.7%) and 2.7% (range: 0-26.5%) in Unguja, and 8.9% (range: 0-31.8%) and 5.5% (range: 0-23.4%) in Pemba, respectively. Heavy infections were detected in 15.1% and 35.6% of the positive school children in Unguja and Pemba, respectively. Males were at higher risk than females (odds ratio (OR): 1.45; 95% confidence interval (CI): 1.03-2.03). Decreasing adult age (OR: 1.04; CI: 1.02-1.06), being born in Pemba (OR: 1.48; CI: 1.02-2.13) or Tanzania (OR: 2.36; CI: 1.16-4.78), and use of freshwater (OR: 2.15; CI: 1.53-3.03) showed higher odds of infection. Community knowledge about schistosomiasis was low. Only few infected Bulinus snails were found. The relatively low S. haematobium prevalence in Zanzibar is a promising starting point for elimination. However, there is a need to improve community knowledge about disease transmission and prevention. Control measures tailored to the local context, placing particular attention to hot-spot areas, high-risk groups, and individuals, will be necessary if elimination is to be achieved
Use of near- and mid-IR hyperspectral imaging for paint identification, as an aid for artwork authentication
In recent years various scientific practices have been adapted to the artwork analysis process and a set of techniques was found advantageous for conservation and restoration works. Apart of these applications, art market also benefits from scientific testing of artwork. Although these services are already available to support determination of the authenticity of traded pieces, they are very expensive and time consuming and therefore serve only very limited range of transactions. As a response for requirements of growing market there is a need for rapid and non-destructive methods empowering art authentication
The use of hyperspectral imaging for cake moisture prediction
In this paper, hyperspectral imaging is demonstrated to be a valid method for predicting the moisture content of baked sponge cakes. The application of this technology in the cake production environment, empowered by sophisticated signal & image processing techniques and prediction algorithms has the potential to provide on-line, real-time, non-destructive cake moisture monitoring
Rapid mapping of schistosomiasis and other neglected tropical diseases in the context of integrated control programmes in Africa
There is growing interest and commitment to the control of schistosomiasis and other so-called neglected tropical diseases (NTDs). Resources for control are inevitably limited, necessitating assessment methods that can rapidly and accurately identify and map high-risk communities so that interventions can be targeted in a spatially-explicit and cost-effective manner. Here, we review progress made with (1) mapping schistosomiasis across Africa using available epidemiological data and, more recently, climate-based risk prediction; (2) the development and use of morbidity questionnaires for rapid identification of high-risk communities of urinary schistosomiasis; and (3) innovative sampling-based approaches for intestinal schistosomiasis, using the lot quality assurance sampling technique. Experiences are also presented for the rapid mapping of other NTDs, including onchocerciasis, loiasis and lymphatic filariasis. Future directions for an integrated rapid mapping approach targeting multiple NTDs simultaneously are outlined, including potential challenges in developing an integrated survey tool. The lessons from the mapping of human helminth infections may also be relevant for the rapid mapping of malaria as its control efforts are intensifie
Harnessing cross-species alignment to discover SNPs and generate a draft genome sequence of a bighorn sheep (Ovis canadensis)
Background: Whole genome sequences (WGS) have proliferated as sequencing technology continues to improve and costs decline. While many WGS of model or domestic organisms have been produced, a growing number of non-model species are also being sequenced. In the absence of a reference, construction of a genome sequence necessitates de novo assembly which may be beyond the ability of many labs due to the large volumes of raw sequence data and extensive bioinformatics required. In contrast, the presence of a reference WGS allows for alignment which is more tractable than assembly. Recent work has highlighted that the reference need not come from the same species, potentially enabling a wide array of species WGS to be constructed using cross-species alignment. Here we report on the creation a draft WGS from a single bighorn sheep (Ovis canadensis) using alignment to the closely related domestic sheep (Ovis aries). Results: Two sequencing libraries on SOLiD platforms yielded over 865 million reads, and combined alignment to the domestic sheep reference resulted in a nearly complete sequence (95% coverage of the reference) at an average of 12x read depth (104 SD). From this we discovered over 15 million variants and annotated them relative to the domestic sheep reference. We then conducted an enrichment analysis of those SNPs showing fixed differences between the reference and sequenced individual and found significant differences in a number of gene ontology (GO) terms, including those associated with reproduction, muscle properties, and bone deposition. Conclusion: Our results demonstrate that cross-species alignment enables the creation of novel WGS for non-model organisms. The bighorn sheep WGS will provide a resource for future resequencing studies or comparative genomics
Characterization of bovine miRNAs by sequencing and bioinformatics analysis
<p>Abstract</p> <p>Background</p> <p>MicroRNAs (miRNAs) are a family of ~22 nucleotide small RNA molecules which regulate gene expression by fully or partially binding to their complementary sequences in mRNAs or promoters. A large number of miRNAs and their expression patterns have been reported in human, mouse and rat. However, miRNAs and their expression patterns in live stock species such as beef cattle are not well studied.</p> <p>Results</p> <p>We constructed and sequenced small-RNA libraries to yield a total of 13,541 small-RNA sequences from 11 bovine tissues including brain, subcutaneous fat, muscle, liver, kidney, spleen and thymus. In total, 228 miRNAs including 29 novel miRNA candidates were identified. Of the 199 miRNAs, 101 have been previously reported as bovine miRNAs and the other 98 are bovine orthologs of known miRNAs that have been identified in at least one other mammalian species. Of the 29 novel miRNA candidates, 17 appeared at this point in time to be bovine specific, while the remaining 12 had evidence of evolutionary conservation in other mammalian species. Five miRNAs (miR-23a, -23b, -99a, -125b and -126-5p) were very abundant across the 11 tissues, accounting for 44.3% of all small RNA sequences. The expression analysis of selected miRNAs using qRT-PCR also showed that miR-26a and -99a were highly expressed in all tissues, while miR-122 and miR-133a were predominantly expressed in liver and muscle, respectively.</p> <p>Conclusion</p> <p>The miRNA expression patterns among 11 tissues from beef cattle revealed that most miRNAs were ubiquitously expressed in all tissues, while only a few miRNAs were tissue specific. Only 60% miRNAs in this study were found to display strand bias, suggesting that there are some key factors for mature miRNA selection other than internal stability. Most bovine miRNAs are highly conserved in other three mammalian species, indicating that these miRNAs may have a role in different species that are potential molecular markers for evolution.</p
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