3D simulations of self-propelled, reconstructed jellyfish using vortex methods

We present simulations of the vortex dynamics associated with the self-propelled motion of jellyfish. The geometry is obtained from image segmentation of video recordings from live jellyfish. The numerical simulations are performed using three-dimensional viscous, vortex particle methods with Brinkman penalization to impose the kinematics of the jellyfish motion. We study two types of strokes recorded in the experiment1. The first type (stroke A) produces two vortex rings during the stroke: one outside the bell during the power stroke and one inside the bell during the recovery stroke. The second type (stroke B) produces three vortex rings: one ring during the power stroke and two vortex rings during the recovery stroke. Both strokes propel the jellyfish, with stroke B producing the highest velocity. The speed of the jellyfish scales with the square root of the Reynolds number. The simulations are visualized in a fluid dynamics video.Comment: 1 page, 1 figur

The 2013 Lunigiana (Central Italy) earthquake: Seismic source analysis from DInSar and seismological data, and geodynamic implications for the northern Apennines. A discussion

We refine the geological data of the 2013 Lunigiana EQ of Pezzo et al. (2014) We report structural constraints for the seismic source of the 2013 Lunigiana EQ. We underline the role of tectonic inheritance for the seismogenic faul

PD-L1/PD-1 axis in multiple myeloma microenvironment and a possible link with CD38-mediated immune-suppression

The emerging role of the PD-1/PD-L1 axis in MM immune-microenvironment has been highlighted by several studies. However, discordant data have been reported on PD-1/PD-L1 distribution within the bone marrow (BM) microenvironment of patients with monoclonal gammopathies. In addition, the efficacy of PD-1/PD-L1 blockade as a therapeutic strategy to reverse myeloma immune suppression and inhibit myeloma cell survival still remains unknown. Recent data suggest that, among the potential mechanisms behind the lack of responsiveness or resistance to anti-PD-L1/PD-1 antibodies, the CD38 metabolic pathways involving the immune-suppressive factor, adenosine, could play an important role. This review summarizes the available data on PD-1/PD-L1 expression in patients with MM, reporting the main mechanisms of regulation of PD-1/PD-L1 axis. The possible link between the CD38 and PD-1/PD-L1 pathways is also reported, highlighting the rationale for the potential use of a combined therapeutic approach with CD38 blocking agents and anti-PD-1/PD-L1 antibodies in order to improve their anti-tumoral effect in MM patients

Particle size distributions by laser diffraction: sensitivity of granular matter strength to analytical operating procedures

We tested laser diffraction particle size analysis in poorly coherent carbonate platform cataclastic breccias and unfaulted quartz-rich eolian sands, representing low- and high-strength granular materials, respectively. We used two different instruments with different sample dispersion and pumping systems and several wet analytical procedures that included different pump speeds, measurement precision tests with and without sample ultrasonication, and different dispersant liquids. Results of our work indicate that high strength material is not strongly affected by analytical operating procedures, whereas low strength materials are very sensitive to the pump speed, ultrasonication intensity, and measurement run time. To reduce such a data variability, we propose a workflow of analytical tests preliminary to the set up of the most appropriate SOP

Adipose-derived stem/stromal cells in kidney transplantation: Status quo and future perspectives

Kidney transplantation (KT) is the gold standard treatment of end-stage renal disease. Despite progressive advances in organ preservation, surgical technique, intensive care, and immunosuppression, long-term allograft survival has not significantly improved. Among the many peri-operative complications that can jeopardize transplant outcomes, ischemia-reperfusion injury (IRI) deserves special consideration as it is associated with delayed graft function, acute rejection, and premature transplant loss. Over the years, several strategies have been proposed to mitigate the impact of IRI and favor tolerance, with rather disappointing results. There is mounting evidence that adipose stem/stromal cells (ASCs) possess specific characteristics that could help prevent, reduce, or reverse IRI. Immunomodulating and tolerogenic properties have also been suggested, thus leading to the development of ASC-based prophylactic and therapeutic strategies in pre-clinical and clinical models of renal IRI and allograft rejection. ASCs are copious, easy to harvest, and readily expandable in culture. Furthermore, ASCs can secrete extracellular vesicles (EV) which may act as powerful mediators of tissue repair and tolerance. In the present review, we discuss the current knowledge on the mechanisms of action and therapeutic opportunities offered by ASCs and ASC-derived EVs in the KT setting. Most relevant pre-clinical and clinical studies as well as actual limitations and future perspective are highlighted

Deformation Sequence and Paleofluids in Carbonate Buckle Folds Under Transpression (Pag Anticline, External Dinarides, Croatia)

Contractional deformation structures at the front of transpressional orogens display complex three-dimensional geometries deviating from the interpretative templates commonly applied in thrust belts. Accordingly, detailed constraints on deformation patterns and associated paleofluid circulation are desirable, especially for fracture geometry and permeability predictive purposes. The Pag anticline, which is located in the Dinaric fold and thrust belt, provides an appropriate field site for studying fold- and fault-related deformation structures in a transpressive setting. We performed a multiscale structural analysis together with petrographic and stable isotope characterization of the deformation-related calcite cements. Structural mapping suggests that the Pag anticline is a detachment fold developed mainly by buckling, since large-scale thrust faults are absent. Fold tightening in a transpressive setting produced a complex deformational structure including two sets of N-S right-lateral and E-W left-lateral late-stage strike-slip fault sets trending oblique to the NW-SE fold axis. The pre-folding deformation pattern includes incipient normal faults likely related to the forebulge stage, veins and stylolites coherent with NE-SW layer parallel shortening contraction in a strike-slip regime, and metric to decametric scale conjugate thrusts coherent with layer parallel shortening in a compressive regime. Buckle folding preceded propagation of a series of accommodation structures during fold tightening. Petrographic and isotopic data indicate meteoric alteration of the Cretaceous platform carbonates in the prefolding stage, likely due to forebulge subaerial exposure. Layer parallel shortening and early syn-folding veins involved formational fluids resulting from mixed marine and meteoric fluids during folding at shallow burial conditions. Eventually, meteoric fluid infiltrated again along strike-slip faults, acting as cross-formational conduits in the postfolding stage

A virtual sensor for electric vehicles’ state of charge estimation

The estimation of the state of charge is a critical function in the operation of electric vehicles. The battery management system must provide accurate information about the battery state, even in the presence of failures in the vehicle sensors. This article presents a new methodology for the state of charge estimation (SOC) in electric vehicles without the use of a battery current sensor, relying on a virtual sensor, based on other available vehicle measurements, such as speed, battery voltage and acceleration pedal position. The estimator was derived from experimental data, employing support vector regression (SVR), principal component analysis (PCA) and a dual polarization (DP) battery model (BM). It is shown that the obtained model is able to predict the state of charge of the battery with acceptable precision in the case of a failure of the current sensor

S100B is not a reliable prognostic index in paediatric TBI.

Pediatr Neurosurg. 2007;43(4):258-64

Experimental study of CO2 sequestration by ECBM recovery: the case of Sulcis coal.

An ECBM (Enhanced Coal Bed Methane) feasibility study started for the Sulcis Coal Province (SW Sardinia, Italy) in December 2004: geochemical, structural-geology, stratigraphic and reservoir engineering considerations are discussed. The first newly gathered experimental data are discussed, including: fluid geochemistry (major and minor elements, dissolved gases, C and He isotopic ratios) of the reservoir, coal composition and experimental data on CO2/CH4 adsorption on coal. A MapInfo GIS structure was built up including stratigraphical, geo-structural, hydrogeochemical, coal-compositional and environmental impact information as well as the CO2 sources location and typology. Even if these data could be preliminary with respect to the coal characteritics effectively located at the future injection depth, they highlighted both the challenging positive and negative aspects of the Sulcis Coal Province versus the exploitation of the ECBM technique. The most important objective of this phase I of the project is the selection of the best Sulcis ECBM test-pilot site, which will be followed (Phase II) by the choice of a scaled up site and possibly by a future network (Phase III). These phases are foreseen to be accompanied by the selection of progressively added CO2 industrial sources, to be used within the project economic spreadsheet model, actually in evolution. CO2 geological storage and CH4 production potentials in Sulcis have been grossly evaluated as a whole, in the frame of the Sardinia region CO2 sources, including the coal-fired power plants, both existent and foreseen (hundreds of millions of tonns of CO2 are possible to be stored underground in the next decades). The reservoir estimates, both for the CO2 injection and for the CH4 production are clearly involving to start the test-site phase exploitation, in the frame of an auspicabile international operative project

Resolución de advección difusión en multi-GPGPU

En este trabajo se presenta la solución del problema de advección difusión mediante un enfoque multi-GPGPU con GPUs ubicados en diferentes nodos del clúster que interactúan mediante el protocolo MPI. La idea es usar descomposición de dominio de modo que cada GPU resuelve una parte del dominio computacional y MPI es usado para intercambiar datos de borde. Los solvers están basados en los métodos de Gradientes Conjugados Cuadrado (CGS) y Gradientes Biconjugado Estabilizado (Bi-CGSTAB) que son métodos usados para resolver problemas donde la matriz A no es simétrica como es el caso del problema de advección difusión. La no simetría aparece debido a la discretización del término advectivo en el contexto del método de volúmenes finitos sobre mallas estructuradas cartesianas de paso constante. Se analizan varias opciones de discretización del término advectivo como ser diferencias centradas, up wind y esquemas de alto orden. Se presenta un análisis teórico de cada uno de estos esquemas y su performance computacional en multi-GPGPU. Se presenta además las propiedades de convergencia de los métodos presentados y su performance computacional en multi-GPGPU.Publicado en: Mecánica Computacional vol. XXXV, no. 10.Facultad de Ingenierí