Reviews

500 Computing Tips for Teachers and Lecturers by Phil Race and Steve McDowell, London: Kogan Page, 1996. ISBN: 0–7494–1931–8. 135 pages, paperback. £15.99

Reviews

Judith Jeffcoate, Multimedia in Practice ‐Technology and Applications, BCS Practitioner Series, Prentice‐Hall International, 1995. ISBN: 0–13–123324–6. £24.95

Trading Places

A number of words become new words when, contemporaneously, the front letter is looped to the back and the back to the front. The first and last letters must be different, of course, and the result of this double loop is that the first and last letters are exchanged. If the middle letters are palindromic, the pair becomes palindromic

An investigation of the role of microsomal oxidative metabolism in the in vivo genotoxicity of 1,2-dichloroethane

In vitro studies have demonstrated that two different metabolic pathways, glutathione conjugation mediated by the glutathione S-transferases and microsomal oxidation, may be involved in the genotoxicity and carcinogenicity of 1,2-dichloroethane (DCE). To evaluate the importance of microsomal oxidative metabolism in the bioactivation of DCE in vivo, male B6C3F1 mice were pretreated with piperonyl butoxide (PIB), an inhibitor of microsomal oxidative metabolism, and the effect of this pretreatment on the extent of hepatic DNA damage produced by DCE was determined 4 hr after DCE administration. The in vivo genotoxicity of 2-chloroethanol, a product of the microsomal oxidative metabolism of DCE, was also investigated. Hepatic DNA damage was measured with a sensitive, alkaline DNA unwinding assay for the presence of single-strand breaks and alkali-labile lesions in DNA. Pretreatment of mice with PIB to inhibit microsomal oxidative metabolism significantly potentiated the hepatic DNA damage observed 4 hr after aa single, 200-mg/kg, ip dose of DCE. Treatment of mice with single, ip doses of 2-chloroethanol as high as 1.2 mmol/kg failed to produce any evidence of single-strand breaks and/or alkali-labile lesions in hepatic DNA. When diethyl maleate (DEM) was used to deplete hepatic glutathione levels prior to administration of 2-chloroethanol, the acute hepatotoxicity of 2-chloroethanol was potentiated but again there was no evidence of hepatic DNA damage. These results indicate that microsomal, oxidative metabolism of DCE to 2-chloroethanol and/or 2 chloroacetaldehyde is not responsible for the hepatic DNA damage observed in these studies after DCE administration.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/25803/1/0000366.pd

What Motivates Men\u27s Involvement in Gender-Based Violence Prevention? Latent Class Profiles and Correlates in an International Sample of Men

Data from an international sample of 392 men who had attended gender-based violence (GBV) prevention events were used to examine motivations for involvement in GBV prevention work. Participants responded to an online survey (available in English, French, and Spanish). The most commonly reported reasons for involvement included concern for related social justice issues (87 percent), exposure to the issue of violence through work (70 percent), hearing a moving story about domestic or sexual violence (59 percent), and disclosure of abuse from someone close to the participant (55 percent). Using a latent class analysis, we identified four profiles of men\u27s motivations: low personal connection (22 percent), empathetic connection (26 percent), violence exposed connection (23 percent), and high personal and empathetic connection (29 percent). Participants classified into these profiles did not differ in length of movement involvement but some differences on key ally variables and by global region did emerge. Implications for engagement strategies and future research are discussed

Surrogate species selection for assessing potential adverse environmental impacts of genetically engineered insect-resistant plants on non-target organisms

Most regulatory authorities require that developers of genetically engineered insect-resistant (GEIR) crops evaluate the potential for these crops to have adverse impacts on valued non-target organisms (NTOs), i.e., organisms not intended to be controlled by the trait. In many cases, impacts to NTOs are assessed using surrogate species, and it is critical that the data derived from surrogates accurately predict any adverse impacts likely to be observed from the use of the crop in the agricultural context. The key is to select surrogate species that best represent the valued NTOs in the location where the crop is going to be introduced, but this selection process poses numerous challenges for the developers of GE crops who will perform the tests, as well as for the ecologists and regulators who will interpret the test results. These issues were the subject of a conference “Surrogate Species Selection for Assessing Potential Adverse Environmental Impacts of Genetically Engineered Plants on Non-Target Organisms” convened by the Center for Environmental Risk Assessment, ILSI Research Foundation. This report summarizes the proceedings of the conference, including the presentations, discussions and the points of consensus agreed to by the participants

Modulating autophagy as a therapeutic strategy for the treatment of paediatric high‐grade glioma

Paediatric high grade glioma (pHGG) represent a therapeutically challenging group of tumours. Despite decades of research there has been a minimal improvement in treatment and the clinical prognosis remains poor. Autophagy, a highly conserved process for recycling metabolic substrates is upregulated in pHGG, promoting tumour progression and evading cell death. There is significant cross talk between autophagy and a plethora of critical cellular pathways, many of which Accepted Article This article is protected by copyright. All rights reserved. are dysregulated in pHGG. The following article will discuss our current understanding of autophagy signalling in pHGG and the potential modulation of this network as a therapeutic target