3 research outputs found
Constitutional Theory in a Nutshell
- Author
- A C Pritchard &
- A Jeffrey
- Adam B Wolf
- Adarand Constructors
- Aileen Kavanagh
- Akhil Reed Amar
- Akron L Rev
- Alex Kozinski
- Alexander Bickel
- Allan See
- Amy L Note
- Andrew M Jacobs
- Andrew See
- Ann Scales
- Anne C Dailey
- Anthony J Sebok
- Anthony Kronman
- Anthony Paul Farley
- Anthony Paul Farley
- Antonin Scalia
- Antonin Scalia
- Antonin Scalia
- B U L Rev
- Baker &
- Baltimore V Mayor Of
- Barry Friedman
- Barry Friedman
- Barry Friedman
- Bernard Bailyn
- Bernard Schwartz
- Bernard Schwartz
- Bernard See
- Bruce A Ackerman
- Burt Neuborne
- C Peter
- Caleb Nelson
- Carol Gilligan
- Cass R Sunstein
- Cass R Sunstein
- Cass R Sunstein &
- Cass See Generally
- Catherine A See Generally
- Charles J Cooper
- Charles R Lawrence
- Cheryl Harris
- Christopher J Peters
- Christopher L Eisgruber
- Christopher P Banks
- Christopher P Banks
- Christopher Wolfe
- Creighton L Rev
- D Kelly Weisberg
- D Mark
- D Scott
- Daniel A See Generally
- Daniel A Sherry
- Daniel Farber
- Daniel N See Generally
- David Bergland
- David C Note
- David Fontana
- David J Garrow
- David L See Generally
- David Mcgowan
- David W Note
- Deborah Rhode
- Dennis W Arrow
- Derrick Bell
- Dorf
- E G
- E G
- E G
- E G
- E G Ake V
- E G Brown V
- E G Clinton V
- E G Gregg V
- E G Jackson V
- E G Mccleskey V
- E G Miranda V
- E G Planned Parenthood Of
- E G Reynolds V
- E G Roe
- E G Roe
- E G Schiro V
- E G See
- E G See
- E G See
- E J Dionne
- Earl M See Generally
- Ed Mark Tushnet
- Edward S Corwin
- Edwin Meese
- Ellis Washington
- Emily Eakin
- Eric J Segall
- Ex Parte Merryman
- Fleming &
- Fleming &
- Fleming &
- Fleming &
- Frances Olsen
- Frederick Schauer
- Frederick Schauer
- Furman V Georgia
- G Edward White
- G Edward White
- G Emery
- G Steven
- G Steven
- Gary Lawson
- Gary Minda
- Gary Peller
- Gene R Nichols
- Geoffrey Stone
- Gerald N Rosenberg
- Gideon V Wainwright
- Girardeau A See Generally
- H Frank
- H Laurence
- H V Michael
- H William
- Hadley Arkes
- Harv J L Pub
- Harv J L Pub
- Henry J Abraham
- Herman See Generally
- Howard Gillman
- Ian F See Generally
- Ian F See Generally
- Id
- Id
- Igor Note
- J M Balkin
- J M See
- J M See
- J Scalia
- Jack N Rakove
- James Boyle
- James C Note
- James E Fleming
- James E See Generally
- James G Wilson
- Jed Rubenfeld
- Jeffrey A Segal &
- Jerold H Israel
- John Harrison
- John Note
- John O See Generally
- John S See Generally
- Jon A Powell
- Jonathan G O&apos
- Jonathan R Macey
- Jules See
- Kathleen M Sullivan
- Kenneth Karst
- Kenneth L Karst
- Kenneth W Starr
- Kimberle Crenshaw
- Kimberl� Crenshaw
- Kniffin
- L J Yale
- L Rev
- Laurence H Tribe
- Lawrence Lessig
- Lawrence See
- Lawrence Sirovich
- Lea Brilmayer
- Lee Epstein
- Lee Epstein &
- Lewis F Powell
- Louis Michael Seidman
- Louis Michael Seidman &
- Lucas A Powe
- Lucas A See Generally
- M Earl
- M Earl
- M Owen
- M Stephen
- Mari J Matsuda
- Mark A See Generally
- Mark Kelman
- Mark Tushnet
- Mark Tushnet
- Mark Tushnet
- Martha Chamallas
- Martha Minow
- Matthew
- Mauro See
- Michael J Gerhardt
- Michael J See Generally
- Michael J See Generally
- Michael Kammen
- Michael Stokes Paulsen
- Michael Stokes Paulsen
- Michael Stokes Paulsen
- Michael W Mcconnell
- Michel Rosenfeld
- Michel Rosenfeld
- Mistretta
- Morrison V Olson
- N Margaret
- Nancy Levit
- Note
- O William
- O&apos
- P Henry
- P Henry
- Patricia J Williams
- Patrick Higginbotham
- Paul Finkelman
- Pauline Maier
- Peggy Cooper
- Philip P Frickey
- Philip P Frickey
- Pierre Schlag
- Pursuit Of Justices-Presidential Politics And The David Alistair Yalof
- Quentin P Taylor
- R
- R
- R Charles
- Ran Hirschl
- Randall Kennedy
- Randy E Barnett
- Randy E Barnett
- Randy E Barnett
- Rebecca L Brown
- Rebecca L Brown
- Richard A Epstein
- Richard A Posner
- Richard A Posner
- Richard A Posner
- Richard A Posner
- Richard Delgado
- Richard E Levy
- Richard Epstein
- Richard H Fallon
- Richard H Fallon
- Richard S Kay
- Richard See Generally
- Robert A See Generally
- Robert D See Generally
- Robert H Bork
- Robert H Bork
- Robert Justin Lipkin
- Robert Lowry See
- Robert See Generally
- Robin L West
- Robin West
- Ronald J Krotoszynski
- Ronald J Krotozynski
- Ronald Kahn
- Ronald See
- Rory K Little
- Roscoe Pound
- Sandra Day
- Sanford Levinson
- Schopp
- Scott E Gant
- Scott P See Generally
- See
- See Erwin Chemerinsky
- See Generally
- See Generally
- See Gerald
- See Robert
- Seth Barrett Tillman
- Sotirios A Barber
- Sotorios See
- Stanley Fish
- Stare Douglas
- Stephen Breyer
- Stephen Holmes
- Stephen M See Also
- Steven Bradford
- Steven D Smith
- Steven L Winter
- Supra Levit
- Supra Levit
- Supra Levit
- Supra Levit
- Surya Prakash
- Surya Prakash
- Suzanna Sherry
- Sylvia A Law
- Taking Mark Tushnet
- The Akhil Reed Amar
- Thomas B Mcaffee
- Thomas E Baker
- Thomas E Baker
- Thomas E Baker
- Thomas E See Generally
- Thomas E. Baker
- Thomas G West
- Thomas Grey
- Thomas Hobbes
- Thomas J Long
- Thomas R Lee
- Thomas R Lee
- Tinsley E Yarbrough
- Todd E Note
- Tracy E Higgins
- U S
- U S Const
- V Harry
- V Mark
- Vincent See Generally
- W Harry
- Walter Berns
- Walter F Murphy
- William S Consovoy
- William W See Generally
- Williams V Illinois
- Yale L
- Yale L
- Younsik Lim
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2003
- Field of study
Part 1. Bibliographies and Other Research and Reference Guides, Including Dictionaries, Encyclopedias, Grammars and Phrase Books
- Author
- Abdi Wazir H.
- Abdullaev K. A.
- Abramson David MacKenzie
- Adams Laura L.
- Adams Laura Lee
- Adib Khalid
- Agadjanian Victor
- Akcali Pinar
- Akiner Shirin
- Akiner Shirin
- Akramov Kamiljon
- al-Khathllan Saleh Mohammed Farhan
- Al-Sati Saud M.
- Alaolmolki Nozar
- Allison Roy
- Alves Marinne
- Amanzholova Dina A.
- Andriessen M.
- Ansari Aimee A.
- Arik Kagan
- Aronson Howard I.
- Asanaliev Tilek Asanalievich
- Asanova Jazira K.
- Babur
- Baijumanov Djanbulat
- Baker Thomas A.
- Baldauf Ingeborg
- Balzer Marjorie M.
- Barton Nan
- Bedford Daniel Peter
- Beiglarbeigi Salaheddin Afshar
- Bell James Ethan
- Benfield Richard W.
- Bertsch Gary K.
- Bockhorst Sarah
- Boljurova Ishengul
- Brooks Karen McConnell
- Brown Andrew James
- Brown Bess
- Burnes Alexander
- Buronov Jamaldin
- Burton Audrey
- Bury Jeffrey T.
- Cajee Mas'ood
- Carlisle Donald S.
- Carlisle Heather Lynn
- Cavanaugh Cassandra
- Cavis Marni D.
- Chabot Philippe Andre
- Charney Craig
- Chenard Stéphane
- Chiappetta Carrie Lynn
- Childress David Hatcher
- Claassen Ernest G.
- Clark William Carl
- Clement Victoria
- Clifford
- Clinton Bill
- Cooper Mary Ewan
- Coudouel Aline
- Craumer Peter
- Cunha Stephem Farrell
- Damrel David W.
- Dave Bhavna
- Deibler Ruth
- Demko George J.
- Dickens Mark
- Dillon Michael
- Din Hayaud
- Din Hayaud
- Dobson Richard B.
- Dobson Richard B.
- Doi Mary M.
- Dosmukhamedov E. K.
- Dror David
- Dunmore Charles Adolphus Murray
- Dzhiembaeva Alia
- Eastep Wayne
- Eastern Middle
- Ebel Robert E.
- Edgeworth Linda
- Eitzen Hilda Carper
- Ellisseeff Vadime
- Ely Delfina Isabel
- Engelmann Kurt E.
- Erdal Marcel
- Erdem Cagri
- Esposito John L.
- Fahnestock Alan L.
- Ferguson Gary A.
- Fihl Esther
- Fletcher Joseph
- Foltz Richard
- Forsythe Rosemarie
- Fosmire Edward D.
- Fox Elizabeth
- Frank Andre Gunder
- Frye Richard N.
- Frye Richard N.
- Gall Timothy L.
- Giebel Herbert Norman
- Gies Jacques
- Gilbert Marshall Kennedy IV
- Gladney Dru C.
- Glazebrook Philip
- Gliha Ryan M.
- Golombek Lisa
- Goodding Robert
- Grace Alexander M.
- Grant Steven A.
- Grant Steven A.
- Grant Steven A.
- Grant Steven A.
- Grant Steven A.
- Grant Steven A.
- Grant Steven A.
- Halpern Rachel
- Hanks Reuel R.
- Harrison Nathaniel P.
- Harrison Tony
- Hedin Sven Anders
- Hedin Sven Anders
- Herrmann Georgina
- Hickey Beth Ellen
- Hiebert Frederick Talmage
- Hocker Aimee C.
- Hopkirk Kathleen
- Husmann Lisa Eileen
- Ibrahim Ablahat
- Igolinskaya Rimma
- Imamkhodjaeva Oidinposha
- Irwin Mark
- Islam Muhammad
- Jackson George R.
- Ji Ping
- Johnson Ericka
- Jones Scott A.
- Jordan David
- Jourdan Uwe
- Kadir Djelal
- Kafesoglu Ibrahim
- Kamberi Dolkun
- Kamp Marianne Ruth
- Kanaev Alexander N.
- Kandiyoti Deniz
- Kangas Roger David
- Kanlidere Ahmet
- Kara Halim
- Karasik Theodore William
- Karimi-Hakkak Ahmad
- Karimov I.
- Kasymov Ilkhom
- Kasymova Nazokat A.
- Kato Shizuko
- Keesbury Jill
- Keller Shoshana
- Keller Shoshana
- Kemal S.
- Kemper Michael
- Keshavjee Salmaan
- Khachaturian Armen G.
- Khakimov Akbar
- Khudonazarov Davlat
- Kiasatpour Soleiman M.
- Kiessling Kerstin L.
- King Steven Douglas
- King William Harris
- Koichuyev T. K.
- Koldys Gregory Richard
- Kostrzewa Thomas Kirk
- Kotenyova Tatyana E.
- Krekel Bryan A.
- Lameer J.
- Landis Edwin R.
- Lape Maureen
- Law David A.
- Levashov Georgiy Georgievich
- Levin Theodore
- Levin Theodore Craig
- Levitin Leonid
- Lewis J. Stuart
- Library of Congress
- Library of Congress
- Library of Congress
- Logachev V. A.
- Luloff Gregory M.
- Luong Pauline Jones
- Luster Aaron
- Lynch Dov
- Lyons Shawn T.
- MacLeod Calum
- Maddock Kenneth
- Manz Beatrice Forbes
- Marefat Roya
- Martin Virginia
- Matas David
- McCabe William A.
- McCray Thomas R.
- McCreery Scott L.
- McDaneld A. Scott
- Meffert Peter R.
- Menon Rajan
- Merefat Roya
- Micallef Roberta Maria
- Michaels Paula A.
- Michaels Paula Anne
- Micklin Philip
- Micklin Philip P.
- Millward James A.
- Mitrokhin N.
- Moriak Christopher Frank
- Musaev Qudrat M.
- Nazarbayev Nursultan N.
- Nazpary Joma
- Nepesova Roza Gaibovna
- Nicolle David
- Northrop Douglas Taylor
- Nowicki Marvin E.
- O'Donnell Jennifer Jane
- Olcott Martha Brill
- Omarova Saule Tarikhovna
- Otorbaev K.
- Paksoy Hasan B.
- Paksoy Hasan B.
- Paterson Michael T.
- Payne Matthew J.
- Peimani Hooman
- Peters Nigel
- Plagier Sally
- Pohl Michaela
- Poliakov Sergei
- Popovych Erika I.
- Powell John D.
- Practical Information
- Privratsky Bruce G.
- Prokhoroff Georges
- Pulley Anne Laura Helena
- Qualin Anthony J.
- Rajaee Bahrain M.
- Rajaee Bahram
- Razvi Syed Abbas Hasan
- Reichl Karl
- Rerikh Nikolai K.
- Rezun Miron
- Richrnan Alvin
- Righetti Scott R.
- Roberts Courtney S.
- Roberts Scan R.
- Rofi'i Imam
- Rottier Peter
- Rouse Mary Patricia Joan
- Rumer Boris Z.
- Rutland Peter
- Rywkin Michael
- Sabol Steven
- Sabol Steven
- Sahadeo Jeffery Frank
- Sato Kyoko
- Savin Kenneth S.
- Schoeberlein-Engel John Samuel
- Schwalbe Nina
- Scott Andrea
- Seaman Gary
- Segas Gregory Paul
- Sewall Bella Katy
- Shackelford Sharen M.
- Shackelford Sharen M.
- Shadmanaw Qurban
- Sharp Deanne
- Sharp John R.
- Shashenkov Maxim
- Shub Anatole
- Shukurov Emil
- Shukurov Emil
- Siegal Jennifer
- Simpson David W.
- Sinnott Peter James
- Sinor Denis
- Skagen Ottar
- Skallerup Thomas Mark
- Skinner R. Kenneth
- Skoczylas Elehie N.
- Small Eric E.
- Smith David Roger
- Song Jun
- Spengler William F.
- Spengler William F.
- Spitkovsky Julia
- Stahl Thomas Brian
- Stanford Mark Steven
- Stein Aurel Sir.
- Stone Christopher Bradford Ian
- Sullivan Barry Lynn
- Swafford Michael
- Söylemez Orhan
- Tadjbakhsh Shahrbanou
- Tadjbakhsh Shahrbanou
- Tadjbakhsh Shahrbanou
- Tang Sniping
- Taube Herman
- Taylor Rupert J.
- Terry Hilja R.
- Thurman J. Michael
- Thurman Michael
- Toops Stanley Winfield
- Tousley Scott W.
- Tritz Julie Ann
- Tsai Tsung-te
- Tylynski Jacqueline K.
- Unseth Benjamin
- Uribes Rebecca
- Utschig A.
- Verrier Anthony
- Vertkin Dmitri
- Vincent Donna M.
- Walter Mariko Namba
- Wang David
- Wang Meng
- Warikoo Kulbhushan
- Wasilewska Ewa
- Wasyliw Lynne Anne
- Watts Ian Kenneth
- Wenmin Liu
- Woff Richard
- Wolfe Keith David
- Wood Leonard James
- Wood William A.
- Wood William A.
- Yasuda Osamu
- Yazar Hatice
- Yu Yaohua
- Zanca Russell G.
- Zeybek A. Yavuz
- Zhang Feng
- Zhao Yueyao
- Zhou Xijuan
- Zimmerman Shelley Ann
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
Whole-genome sequencing reveals host factors underlying critical COVID-19
- Author
- Abd Elghafar Mohamed S.
- Abdel-Aziz Mahmoud
- Abdelrazik Marwa
- Abdollahi Hamed
- Abdullah T.
- Abecasis Goncalo
- Abedalthagafi M.
- Abel Lynn
- Abernathy C.
- Abraheem Azmeralde
- Abul-Husn Noura S.
- Acquilini D.
- Adams C.
- Adams Emma L.
- Adams K.
- Adamsara Alireza
- Adanini Olurenke
- Adeleye O.
- Adra D.
- Afilalo J.
- Afilalo M.
- Afolabi D.
- Afrasiabi Z.
- Agasou A.
- Agrawal Shruti
- Agüero D.
- Ahmad N.
- Ahmadi Saeideh
- Ahmed A.
- Ahmed Cecilia
- Akeroyd L.
- Akhtar M.N.
- Akinkugbe O.
- Aksentijevich Alexandra
- Al-Afghani H.
- Al-Awdah L.
- Alaamery M.
- Alahmadey Z.Z.
- Alaverdian D.
- Alavere H.
- Albader A.
- Albaiceta G.M.
- Albakri J.K.
- AlBardis H.
- Albeladi M.
- Albesher N.
- Albrich W.
- AlDhawi N.
- Aldridge J.
- Aleagha Afshar Etemadi
- Alexander Peter.
- Alfonso J.
- Alghamdi B.
- Alghamdi J.
- Ali A.
- Ali Altaf
- Ali I.A.M.
- Ali Syamlan
- Aliannejad Rasoul
- Aljawini N.
- AlJohani S.
- Alkwai S.
- Allan A.
- Allan E.
- Allan J.
- Alldis Zoe
- Allen L.
- Allen Meryem
- Allen Schvearn
- Allibone S.
- Allison K.S.
- Allos R.
- Ally S.M.
- AlMalik A.
- Almalki F.
- Almohammed I.
- Almutairi M.
- Alotaibi S.
- Alowayn A.M.
- Alqahtani S.
- Alqubaishi F.
- Alrashed M.
- Alshareef A.
- Alsolm E.
- Alswailm M.
- Altabaibeh A.
- Alvaro A.
- AlZahrani D.
- Amin V.
- Amirsavadkouhi Ali
- Amitrano Sara
- Anastasescu E.
- Anderson F.
- Anderson J.
- Anderson Madeleine
- Anderson Peter
- Anderson S.
- Anderson S.
- Anderson T.
- Andolfo I.
- Andretta F.
- Andreucci E.
- Andrew Angela
- Andrew B.
- Andrew Gratrix
- Andrews E.
- Andrews Shea J.
- Anedda F.
- Anemoli V.
- Annis A.
- Antcliffe David
- Antinori Andrea
- Antoni M.D.
- Anumakonda V.
- Apetri E.
- Aquino Maia
- Arabi Y.M.
- Aravindan Latha
- Arbane Gill
- Archer Katie
- Arden T.
- Arias Sonia Sousa
- Arif S.
- Armstrong Jacob
- Armstrong Lisa
- Armstrong Ruth
- Arning N.
- Arnold Sophie
- Arranz María Jesús
- Arribas E.
- Artuso R.
- Arumugam Prabhu
- Ascolillo Steven
- Ashraf Saima
- Ashton L.
- Aslibekyan S.
- Astin-Chamberlain Raine
- Atkinson E.G.
- Attwood B.
- Aucella F.
- Auld D.
- Auld F.
- Austin Karen
- Austin Pauline
- Auton A.
- Ayers A.
- Azarzar S.
- Bachetti T.
- Baikady R.R.
- Baillie John Kenneth
- Baines Balvinder
- Baines D.
- Baines K.
- Baird Yolanda
- Bakthavatsalam Dhanalakshmi
- Balaconis Mary K.
- Baldassarri M.
- Ball C.A.
- Baltzell A.H.
- Bamford A.
- Bamford Peter
- Banach Dorota
- Bancroft Hollie
- Band G.
- Bandini M.
- Bandla Nageswar
- Bano S.
- Baptista David
- Barakeh D.
- Baras Aris
- Baratti S.
- Barber R.
- Barberis L.
- Barbieri C.
- Barclay Lucy
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- Barhoush E.
- Barker J.
- Barnes K.C.
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- Barrett F.
- Barron A.
- Barry P.
- Bartels M.
- Bartley Shauna
- Baruah R.
- Bashyal Archana
- Basikolo C.
- Bassetti M.
- Bastion V.
- Bates H.
- Bates Michelle
- Batini Chiara
- Battle Ceri
- Bauchmuller K.
- Baxter N.
- Baya N.
- Bayo L.A.
- Beadle Jane
- Bean S.
- Beaumont K.
- Beavis S.
- Beck A.
- Beckmann Noam D.
- Bedini J. L.
- Bee Catherine E.
- Beech E.
- Beech Valerie
- Beekes M.
- Beesley K.
- Begg Colin
- Beguin Y.
- Behan T.
- Beith C.M.
- Belagodu Zakaula
- Belbin Gillian Morven
- Belfield H.
- Belhaj Y.
- Beligni G.
- Belisle A.
- Bell D.
- Bell G.
- Bell M.
- Bell S.
- Bellamy Mary
- Belli M.A.
- Bellini A.
- Bellwood R.
- Below Jennifer
- Bemand T.
- Benetti E.
- Benham Leonie
- Bennett D.
- Bennett Sara
- Bentley David
- Bentley M.
- Benyon S.
- Beranova E.
- Bercades G.
- Bergantini L.
- Bergomi P.
- Berkowitz Nathan
- Bernardo D.
- Bevan E.
- Bewley J.
- Bhatia Nikhil
- Bhatterjee Ravi
- Bhuie Parminder
- Bi R.
- Biagio A.D.
- Bianchi F.
- Bibert S.
- Bibi Fatima
- Biddle Jack
- Biggs Heather
- Birch J.
- Birch J.
- Birch Sophie.
- Birchall K.
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- Bird S.
- Birkinshaw Isobel
- Birt M.
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- Black K.
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- Blackman H.
- Blakemore H.
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- Board S.
- Bochud P.Y.
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- Boezen M.
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- Bokhari M.
- Bolton Matthew
- Bolton Rachel
- Bonner Stephen
- Booker L.
- Borislavova B.
- Borra Catherine
- Botello A.
- Botfield Liam
- Bottà G.
- Bouab M.
- Bough L.
- Boughton A.P.
- Bowes A.
- Bowles Ruth
- Boyle P.
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- Bradley C.
- Bradley P.
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- Bradshaw Zena
- Brady A.
- Brady M.
- Brady R.
- Brandwood C.
- Branney D.
- Brantwood Craig
- Brassard N.
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- Brealey D.
- Bremmer P.
- Brenner B.
- Bretherick Andrew D.
- Brett Michael
- Brett Stephen
- Brickell K.
- Bridgett V.
- Brimfield Lutece
- Brinkworth Elaine
- Briton Kate
- Britvan Bari
- Bromley M.
- Brooke Hollie
- Brooks S.
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- Brown Adam
- Brown C.W.
- Brown Ellen
- Brown Joanna
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- Brunton Mark
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- Bryant S.
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- Buckley Sarah
- Bunni L.
- Burda D.
- Buring Julie E
- Burn I.
- Burnett C.
- Burns K.
- Burt K.
- Burtenshaw Andrew
- Burton Maudrian
- Busani S.
- Bussotti M.
- Butcher D.
- Butler Aaron
- Butler Joanna
- Butler S.
- Butler-Laporte G.
- Butterworth A.S.
- Butterworth-Cowin N.
- Button H.
- Buxbaum Joseph D
- Cabrelli Louise
- Cagova L.
- Caldarelli G.P.
- Callaghan Marie
- Callier S.
- Cameli Paolo
- Campbell Archie
- Campbell Archie
- Campbell Helen
- Campbell Rachael
- Campbell Suzanne
- Campos Sara
- Camsooksai J.
- Canaccini A.
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- Capasso M.
- Capitani K.
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- Carmody Margaret
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- Carter David
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- Carter Joseph
- Carter S.
- Carungcong J.
- Casey Matt
- Castaño-Vinyals G.
- Castelli F.
- Castle K.
- Castori M.
- Caswell Melanie
- Catena E.
- Caterson Jess
- Cathcart Susanne
- Catlow L.
- Caulfield Mark J.
- Cavazza Anna
- Cawley Kathryn
- Cawthron K.
- Ceri S.
- Chablani M.
- Chadbourn Indra
- Chamnanphon Monpat
- Chan Georgia
- Chan R.
- Chandler B.
- Chang Xiao
- Chapman Susan
- Chariyavilaskul Pajaree
- Charles B.
- Charlesworth Ruth
- Charney Alexander W.
- Charnock R.
- Chasman D.I.
- Chassé M.
- Chaudhary Kumardeep
- Chavan S.
- Cheema Yusuf
- Chen Hung-Hsin
- Chen Jiantao
- Cheng N.
- Cherian Shiney
- Chetam L.
- Chetruengchai Wanna
- Cheyne C.
- Childs D.
- Chittoor G.
- Cho Judy H.
- Cho K.
- Choi Sam
- Choudhury Yasmin
- Christine Almaden-Boyle None
- Chukkambotla Srikanth
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- Åsvold Bjørn Olav
- Publication venue
- Publication date
- 01/01/2022
- Field of study
Altres ajuts: Department of Health and Social Care (DHSC); Illumina; LifeArc; Medical Research Council (MRC); UKRI; Sepsis Research (the Fiona Elizabeth Agnew Trust); the Intensive Care Society, Wellcome Trust Senior Research Fellowship (223164/Z/21/Z); BBSRC Institute Program Support Grant to the Roslin Institute (BBS/E/D/20002172, BBS/E/D/10002070, BBS/E/D/30002275); UKRI grants (MC_PC_20004, MC_PC_19025, MC_PC_1905, MRNO2995X/1); UK Research and Innovation (MC_PC_20029); the Wellcome PhD training fellowship for clinicians (204979/Z/16/Z); the Edinburgh Clinical Academic Track (ECAT) programme; the National Institute for Health Research, the Wellcome Trust; the MRC; Cancer Research UK; the DHSC; NHS England; the Smilow family; the National Center for Advancing Translational Sciences of the National Institutes of Health (CTSA award number UL1TR001878); the Perelman School of Medicine at the University of Pennsylvania; National Institute on Aging (NIA U01AG009740); the National Institute on Aging (RC2 AG036495, RC4 AG039029); the Common Fund of the Office of the Director of the National Institutes of Health; NCI; NHGRI; NHLBI; NIDA; NIMH; NINDS.Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care or hospitalization after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes-including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)-in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease