9,558 research outputs found
Aspects of the prevalence, aetiology and prevention of anencephalus and spina bifida in Glasgow, 1972-78
Quasi-Chemical and Structural Analysis of Polarizable Anion Hydration
Quasi-chemical theory is utilized to analyze the roles of solute polarization
and size in determining the structure and thermodynamics of bulk anion
hydration for the Hofmeister series Cl, Br, and I. Excellent
agreement with experiment is obtained for whole salt hydration free energies
using the polarizable AMOEBA force field. The quasi-chemical approach exactly
partitions the solvation free energy into inner-shell, outer-shell packing, and
outer-shell long-ranged contributions by means of a hard-sphere condition.
Small conditioning radii, even well inside the first maximum of the
ion-water(oxygen) radial distribution function, result in Gaussian behavior for
the long-ranged contribution that dominates the ion hydration free energy. The
spatial partitioning allows for a mean-field treatment of the long-ranged
contribution, leading to a natural division into first-order electrostatic,
induction, and van der Waals terms. The induction piece exhibits the strongest
ion polarizability dependence, while the larger-magnitude first-order
electrostatic piece yields an opposing but weaker polarizability dependence. In
addition, a structural analysis is performed to examine the solvation
anisotropy around the anions. As opposed to the hydration free energies, the
solvation anisotropy depends more on ion polarizability than on ion size:
increased polarizability leads to increased anisotropy. The water dipole
moments near the ion are similar in magnitude to bulk water, while the ion
dipole moments are found to be significantly larger than those observed in
quantum mechanical studies. Possible impacts of the observed over-polarization
of the ions on simulated anion surface segregation are discussed.Comment: slight revision, in press at J. Chem. Phy
Estimating Probability Distributions from Complex Models with Bifurcations: The Case of Ocean Circulation Collapse
Abstract in HTML and technical report in PDF available on the Massachusetts Institute of Technology Joint Program on the Science and Policy of Global Change website (http://mit.edu/globalchange/www/).Studying the uncertainty in computationally expensive models has required the development of specialized methods, including alternative sampling techniques and response surface approaches. However, existing techniques for response surface development break down when the model being studied exhibits discontinuities or bifurcations. One uncertain variable that exhibits this behavior is the thermohaline circulation (THC) as modeled in three-dimensional general circulation models. This is a critical uncertainty for climate change policy studies. We investigate the development of a response surface for studying uncertainty in THC using the Deterministic Equivalent Modeling Method, a stochastic technique using expansions in orthogonal polynomials. We show that this approach is unable to reasonably approximate the model response. We demonstrate an alternative representation that accurately simulates the model’s response, using a basis function with properties similar to the model’s response over the uncertain parameter space. This indicates useful directions for future methodological improvements.This research was supported in part by the Methods and Models for Integrated Assessments Program of the National Science Foundation, Grant ATM-9909139, by the Office of Science (BER), U.S. Department of Energy, Grant Nos. DE-FG02-02ER63468 and DE-FG02-93ER61677, and by the MIT Joint Program on the Science and Policy of Global Change (JPSPGC)
Stages of development and injury: an epidemiological survey of young children presenting to an emergency department
<p><b>Background:</b> The aim of our study was to use a local (Glasgow, west of Scotland) version of a Canadian injury surveillance programme (CHIRPP) to investigate the relationship between the developmental stage of young (pre-school) children, using age as a proxy, and the occurrence (incidence, nature, mechanism and location) of injuries presenting to a Scottish hospital emergency department, in an attempt to replicate the findings of a recent study in Kingston, Canada.</p>
<p><b>Methods:</b> We used the Glasgow CHIRPP data to perform two types of analyses. First, we calculated injury rates for that part of the hospital catchment area for which reasonably accurate population denominators were available. Second, we examined detailed injury patterns, in terms of the circumstances, mechanisms, location and types of injury. We compared our findings with those of the Kingston researchers.</p>
<p><b>Results:</b> A total of 17,793 injury records for children aged up to 7 years were identified over the period 1997–99. For 1997–2001, 6,188 were used to calculate rates in the west of the city only. Average annual age specific rates per 1000 children were highest in both males and females aged 12–35 months. Apart from the higher rates in Glasgow, the pattern of injuries, in terms of breakdown factors, mechanism, location, context, and nature of injury, were similar in Glasgow and Kingston.</p>
<p><b>Conclusion:</b> We replicated in Glasgow, UK, the findings of a Canadian study demonstrating a correlation between the pattern of childhood injuries and developmental stage. Future research should take account of the need to enhance statistical power and explore the interaction between age and potential confounding variables such as socio-economic deprivation. Our findings highlight the importance of designing injury prevention interventions that are appropriate for specific stages of development in children.</p>
Gluteal compartment syndrome following elective unilateral internal iliac artery embolization before endovascular abdominal aortic aneurysm repair
AbstractDuring endovascular abdominal aortic aneurysm repair, aneurysmal involvement of the common or internal iliac arteries occasionally necessitates elective occlusion of one or both internal iliac arteries. Although elective internal iliac artery occlusion is often well tolerated, it can result in complications such as buttock claudication or rest pain, impotence, and colon ischemia. We report a case of gluteal compartment syndrome following elective unilateral internal iliac artery embolization prior to endovascular abdominal aortic aneurysm repair. On the first postoperative day, the patient developed sciatic nerve palsy, rhabdomyolysis, and renal failure, which promptly resolved after emergent operative exploration of his left buttock and debridement of all grossly necrotic muscle. This case emphasizes the point that, although elective internal iliac artery interruption is usually benign, it can have serious and unexpected complications that necessitate expeditious treatment for complete recovery
Superconductivity in Co-doped LaFeAsO
Here we report the synthesis and basic characterization of LaFe1-xCoxAsO for
several values of x. The parent phase LaFeAsO orders antiferromagnetically (TN
~ 145 K). Replacing Fe with Co is expected to both electron dope the system and
introduce disorder in the FeAs layer. For x = 0.05 antiferromagnetic order is
destroyed and superconductivity is observed at Tconset = 11.2 K. For x = 0.11
superconductivity is observed at Tc(onset) = 14.3 K, and for x = 0.15 Tc = 6.0
K. Superconductivity is not observed for x = 0.2 and 0.5, but for x = 1, the
material appears to be ferromagnetic (Tc ~ 56 K) as judged by magnetization
measurements. We conclude that Co is an effective dopant to induce
superconductivity. Somewhat surprisingly, the system appears to tolerate
considerable disorder in the FeAs planes.Comment: 19 pages, 9 figure
Obesity Is A Modifier of Autonomic Cardiac Responses to Fine Metal Particulates
Background: Increasing evidence suggests that obesity may impart greater susceptibility to adverse effects of air pollution. Particulate matter, especially PM (particulate matter with aero-dynamic diameter ≤2.5 μm), is associated with increased cardiac events and reduction of heart rate variability (HRV).Objectives Our goal was to investigate whether particle-mediated autonomic modulation is aggravated in obese individuals.Methods We examined PM-mediated acute effects on HRV and heart rate (HR) using 10 24-hr and 13 48-hr ambulatory electrocardiogram recordings collected from 18 boilermakers (39.5 ± 9.1 years of age) exposed to high levels of metal particulates. Average HR and 5-min HRV [SDNN: standard deviation of normal-to-normal intervals (NN); rMSSD: square-root of mean squared-differences of successive NN intervals; HF: high-frequency power 0.15–0.4 Hz] and personal PM exposures were continuously monitored. Subjects with body mass index ≥ 30 kg/m were classified as obese. Mixed-effect models were used for statistical analyses. Results: Half (50%) of the study subjects were obese. After adjustment for confounders, each 1-mg/m increase in 4-hr moving average PM was associated with HR increase of 5.9 bpm [95% confidence interval (CI), 4.2 to 7.7] and with 5-min HRV reduction by 6.5% (95% CI, 1.9 to 11.3%) for SDNN, 1.7% (95% CI, –4.9 to 8.4%) for rMSSD, and 8.8% (95% CI, –3.8 to 21.3%) for HF. Obese individuals had greater PM-mediated HRV reductions (2- to 3-fold differences) than nonobese individuals, and had more PM-mediated HR increases (9-bpm vs. 4-bpm increase in HR for each 1-mg/m increase in PM; p < 0.001). Conclusions: Our study revealed greater autonomic cardiac responses to metal particulates in obese workers, supporting the hypothesis that obesity may impart greater susceptibility to acute cardiovascular effects of fine particles
The Effect of Muscle Fatigue on Muscle Force-Couple Activation of the Shoulder
Context: Muscle fatigue is an important concept in regard to the muscle function of the shoulder joint. Its effect on the muscle force couples of the glenohumeral joint has not been fully identified. Objective: To examine the effects of muscle fatigue on muscle force-couple activation in the normal shoulder. Design: Pretest, posttest. Patients: Ten male subjects, age 18Ð30 years, with no previous history of shoulder problems. Main Outcome Measures: EMG (area) values were assessed for the anterior and middle deltoid, subscapularis, and infraspinatus muscles during 4 dynamic stabilizing exercises before and after muscle fatigue. The exercises examined were a push-up, horizontal abduction, segmental stabilization, and rotational movement on a slide board. Results: No significant differences were observed for any of the muscles tested. Conclusions: The results of our study indicate that force-couple coactivation of the glenohumeral joint is not significantly altered after muscle fatigue
IgG4-Related Disease Is Not Associated with Antibody to the Phospholipase A2 Receptor
Patients with IgG4-related disease (IgG4-RD) share histopathological characteristics that are similar across affected organs. The finding of infiltration with IgG4+ plasma cells in the proper clinical and histopathological contexts connects a large number of clinical entities that were viewed previously as separate conditions. The renal involvement in IgG4-RD is usually characterized by tubulointerstitial nephritis, but membranous nephropathy has also been reported to be one of the renal complications of IgG4-RD. The recent discovery that a high proportion of patients with idiopathic membranous nephropathy (IMN) have IgG4 autoantibodies to the M-type phospholipase A2 receptor (PLA2R) in the circulation and glomerular immune deposits, together with the profound IgG4 hypergammaglobulinemia and occasional reports of membranous nephropathy in IgG4-RD, raised the question of a common antigen. To assess the presence of anti-PLA2R antibody in patients with IgG4-RD, we screened sera from 28 IgG4-RD patients by immunoblot. None of the patients in this cohort had detectable circulating anti-PLA2R antibodies. This study suggests that despite some clinical and serological overlaps between IgG4-RD and IMN,anti-PLA2R antibodies do not play a role in the pathogenesis of IgG4-RD. Additional studies of IgG4-RD with evidence of membranous nephropathy are important to exclude any definite relationship
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