Spontaneous Resonances and the Coherent States of the Queuing Networks

We present an example of a highly connected closed network of servers, where the time correlations do not go to zero in the infinite volume limit. This phenomenon is similar to the continuous symmetry breaking at low temperatures in statistical mechanics. The role of the inverse temperature is played by the average load.Comment: 3 figures added, small correction

A stochastic network with mobile users in heavy traffic

We consider a stochastic network with mobile users in a heavy-traffic regime. We derive the scaling limit of the multi-dimensional queue length process and prove a form of spatial state space collapse. The proof exploits a recent result by Lambert and Simatos which provides a general principle to establish scaling limits of regenerative processes based on the convergence of their excursions. We also prove weak convergence of the sequences of stationary joint queue length distributions and stationary sojourn times.Comment: Final version accepted for publication in Queueing Systems, Theory and Application

Functional responses of methanogenic archaea to syntrophic growth.

Methanococcus maripaludis grown syntrophically with Desulfovibrio vulgaris was compared with M. maripaludis monocultures grown under hydrogen limitation using transcriptional, proteomic and metabolite analyses. These measurements indicate a decrease in transcript abundance for energy-consuming biosynthetic functions in syntrophically grown M. maripaludis, with an increase in transcript abundance for genes involved in the energy-generating central pathway for methanogenesis. Compared with growth in monoculture under hydrogen limitation, the response of paralogous genes, such as those coding for hydrogenases, often diverged, with transcripts of one variant increasing in relative abundance, whereas the other was little changed or significantly decreased in abundance. A common theme was an apparent increase in transcripts for functions using H(2) directly as reductant, versus those using the reduced deazaflavin (coenzyme F(420)). The greater importance of direct reduction by H(2) was supported by improved syntrophic growth of a deletion mutant in an F(420)-dependent dehydrogenase of M. maripaludis. These data suggest that paralogous genes enable the methanogen to adapt to changing substrate availability, sustaining it under environmental conditions that are often near the thermodynamic threshold for growth. Additionally, the discovery of interspecies alanine transfer adds another metabolic dimension to this environmentally relevant mutualism

Mechanism for microbial population collapse in a fluctuating resource environment.

Managing trade-offs through gene regulation is believed to confer resilience to a microbial community in a fluctuating resource environment. To investigate this hypothesis, we imposed a fluctuating environment that required the sulfate-reduce

Neurological manifestation (headache and ischemic stroke) is the onset of the atypical hemolythic uremic syndrome

Atypical hemolytic uremic syndrome is an orphan disease with a rare (10 % of cases) involvement in the pathological process of the central nervous system. The following symptoms are impaired consciousness, convulsions, strokes, transient ischemic attacks and headache. Presented by the observation of the patient, which had the neurological symptoms at the onset of the disease.Атипичный гемолитико-уремический синдром является орфанным заболеванием с редким (в 10% случаев) вовлечением в патологический процесс центральной нервной системы. Возможны следующие проявления: нарушение сознания, судороги, острые наррения мозгового кровообращения, транзиторные ишемические атаки, головная боль. Представлено клиническое наблюдение пациентки, у которой в дебюте заболевания преобладала неврологическая симптоматика

A stable genetic polymorphism underpinning microbial syntrophy

Syntrophies are metabolic cooperations, whereby two organisms co-metabolize a substrate in an interdependent manner. Many of the observed natural syntrophic interactions are mandatory in the absence of strong electron acceptors, such that one species in the syntrophy has to assume the role of electron sink for the other. While this presents an ecological setting for syntrophy to be beneficial, the potential genetic drivers of syntrophy remain unknown to date. Here, we show that the syntrophic sulfate-reducing species Desulfovibrio vulgaris displays a stable genetic polymorphism, where only a specific genotype is able to engage in syntrophy with the hydrogenotrophic methanogen Methanococcus maripaludis. This 'syntrophic' genotype is characterized by two genetic alterations, one of which is an in-frame deletion in the gene encoding for the ion-translocating subunit cooK of the membrane-bound COO hydrogenase. We show that this genotype presents a specific physiology, in which reshaping of energy conservation in the lactate oxidation pathway enables it to produce sufficient intermediate hydrogen for sustained M. maripaludis growth and thus, syntrophy. To our knowledge, these findings provide for the first time a genetic basis for syntrophy in nature and bring us closer to the rational engineering of syntrophy in synthetic microbial communities