The interaction of class and gender in illness narratives

This is the author's accepted manuscript. The final published article is available from the link below. Copyright @ 2008 BSA Publications Ltd.Perspectives on gender and identity that emphasize variability of performance, local context and individual agency have displaced earlier paradigms.These are now perceived to have supported gender stereotypes and language ideologies by emphasizing gender difference and homogeneity within genders. In a secondary analysis of health and illness narratives we explore the interaction of class and gender in individuals' constructions of gendered identity. High social class men perform gender in particularly varied ways and we speculate that this variable repertoire, including the use of what was once termed `women's language', is linked to a capacity to maintain social distinction and authority. Men's performance of conventional masculinity is often threatened by both the experience of illness and being interviewed about personal experience. Lower social class women in particular demonstrate an intensification of a pre-existing informal family and support group culture, marking successful members by awarding them the accolade of being `lovely'.ESR

Non-Abelian Vortices on Cylinder -- Duality between vortices and walls

We investigate vortices on a cylinder in supersymmetric non-Abelian gauge theory with hypermultiplets in the fundamental representation. We identify moduli space of periodic vortices and find that a pair of wall-like objects appears as the vortex moduli is varied. Usual domain walls also can be obtained from the single vortex on the cylinder by introducing a twisted boundary condition. We can understand these phenomena as a T-duality among D-brane configurations in type II superstring theories. Using this T-duality picture, we find a one-to-one correspondence between the moduli space of non-Abelian vortices and that of kinky D-brane configurations for domain walls.Comment: 33 pages, 17 figures, v2: references added, typos corrected, the final version published in PR

Instantons in the Higgs Phase

When instantons are put into the Higgs phase, vortices are attached to instantons. We construct such composite solitons as 1/4 BPS states in five-dimensional supersymmetric U(Nc) gauge theory with Nf(>=Nc) fundamental hypermultiplets. We solve the hypermultiplet BPS equation and show that all 1/4 BPS solutions are generated by an Nc x Nf matrix which is holomorphic in two complex variables, assuming the vector multiplet BPS equation does not give additional moduli. We determine the total moduli space formed by topological sectors patched together and work out the multi-instanton solution inside a single vortex with complete moduli. Small instanton singularities are interpreted as small sigma-model lump singularities inside the vortex. The relation between monopoles and instantons in the Higgs phase is also clarified as limits of calorons in the Higgs phase. Another type of instantons stuck at an intersection of two vortices and dyonic instantons in the Higgs phase are also discussed.Comment: 32 pages, 6 figures, typos corrected, comments and references adde

The acquisition of Sign Language: The impact of phonetic complexity on phonology

Research into the effect of phonetic complexity on phonological acquisition has a long history in spoken languages. This paper considers the effect of phonetics on phonological development in a signed language. We report on an experiment in which nonword-repetition methodology was adapted so as to examine in a systematic way how phonetic complexity in two phonological parameters of signed languages — handshape and movement — affects the perception and articulation of signs. Ninety-one Deaf children aged 3–11 acquiring British Sign Language (BSL) and 46 hearing nonsigners aged 6–11 repeated a set of 40 nonsense signs. For Deaf children, repetition accuracy improved with age, correlated with wider BSL abilities, and was lowest for signs that were phonetically complex. Repetition accuracy was correlated with fine motor skills for the youngest children. Despite their lower repetition accuracy, the hearing group were similarly affected by phonetic complexity, suggesting that common visual and motoric factors are at play when processing linguistic information in the visuo-gestural modality

The (In)Authenticity of Simulated Talk: Comparing Role-Played and Actual Interaction and the Implications for Communication Training

This article was published in the journal, Research on Language and Social Interaction [Taylor & Francis (Routledge)] and the definitive version is available at: http://dx.doi.org/10.1080/08351813.2013.780341How authentic is simulated, or role-played, interaction, of the kind produced in communication training contexts? The article addresses this question by comparing actual and role-played police investigative interviews. Both types of interviews were recorded by the police: real ones to fulfill British legal requirements and training ones to maximize the authenticity of the training experience. Interview openings were examined using conversation analysis. Officers must adhere to Police and Criminal Evidence Act (2008) guidelines, turning them into spoken actions. The analyses revealed that while, in gross terms, officers in real and simulated interviews opened interviews by formulating the same actions (e.g., identifying copresent parties), differences were observable in their design and organization. In simulations, actions were more elaborate or exaggerated; that is, they were made interactionally visible and “assessable.” Furthermore, some actions were only present in simulations. Implications for the efficacy of role-play methods for training and assessing communication are discussed

Solitons in the Higgs phase -- the moduli matrix approach --

We review our recent work on solitons in the Higgs phase. We use U(N_C) gauge theory with N_F Higgs scalar fields in the fundamental representation, which can be extended to possess eight supercharges. We propose the moduli matrix as a fundamental tool to exhaust all BPS solutions, and to characterize all possible moduli parameters. Moduli spaces of domain walls (kinks) and vortices, which are the only elementary solitons in the Higgs phase, are found in terms of the moduli matrix. Stable monopoles and instantons can exist in the Higgs phase if they are attached by vortices to form composite solitons. The moduli spaces of these composite solitons are also worked out in terms of the moduli matrix. Webs of walls can also be formed with characteristic difference between Abelian and non-Abelian gauge theories. We characterize the total moduli space of these elementary as well as composite solitons. Effective Lagrangians are constructed on walls and vortices in a compact form. We also present several new results on interactions of various solitons, such as monopoles, vortices, and walls. Review parts contain our works on domain walls (hep-th/0404198, hep-th/0405194, hep-th/0412024, hep-th/0503033, hep-th/0505136), vortices (hep-th/0511088, hep-th/0601181), domain wall webs (hep-th/0506135, hep-th/0508241, hep-th/0509127), monopole-vortex-wall systems (hep-th/0405129, hep-th/0501207), instanton-vortex systems (hep-th/0412048), effective Lagrangian on walls and vortices (hep-th/0602289), classification of BPS equations (hep-th/0506257), and Skyrmions (hep-th/0508130).Comment: 89 pages, 33 figures, invited review article to Journal of Physics A: Mathematical and General, v3: typos corrected, references added, the published versio

Surfactant protein D inhibits HIV-1 infection of target cells via interference with gp120-CD4 interaction and modulates pro-inflammatory cytokine production

© 2014 Pandit et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.Surfactant Protein SP-D, a member of the collectin family, is a pattern recognition protein, secreted by mucosal epithelial cells and has an important role in innate immunity against various pathogens. In this study, we confirm that native human SP-D and a recombinant fragment of human SP-D (rhSP-D) bind to gp120 of HIV-1 and significantly inhibit viral replication in vitro in a calcium and dose-dependent manner. We show, for the first time, that SP-D and rhSP-D act as potent inhibitors of HIV-1 entry in to target cells and block the interaction between CD4 and gp120 in a dose-dependent manner. The rhSP-D-mediated inhibition of viral replication was examined using three clinical isolates of HIV-1 and three target cells: Jurkat T cells, U937 monocytic cells and PBMCs. HIV-1 induced cytokine storm in the three target cells was significantly suppressed by rhSP-D. Phosphorylation of key kinases p38, Erk1/2 and AKT, which contribute to HIV-1 induced immune activation, was significantly reduced in vitro in the presence of rhSP-D. Notably, anti-HIV-1 activity of rhSP-D was retained in the presence of biological fluids such as cervico-vaginal lavage and seminal plasma. Our study illustrates the multi-faceted role of human SPD against HIV-1 and potential of rhSP-D for immunotherapy to inhibit viral entry and immune activation in acute HIV infection. © 2014 Pandit et al.The work (Project no. 2011-16850) was supported by Medical Innovation Fund of Indian Council of Medical Research, New Delhi, India (www.icmr.nic.in/)

Building an Assessment Use Argument for sign language: the BSL Nonsense Sign Repetition Test

In this article, we adapt a concept designed to structure language testing more effectively, the Assessment Use Argument (AUA), as a framework for the development and/or use of sign language assessments for deaf children who are taught in a sign bilingual education setting. By drawing on data from a recent investigation of deaf children's nonsense sign repetition skills in British Sign Language, we demonstrate the steps of implementing the AUA in practical test design, development and use. This approach provides us with a framework which clearly states the competing values and which stakeholders hold these values. As such, it offers a useful foundation for test-designers, as well as for practitioners in sign bilingual education, for the interpretation of test scores and the consequences of their use