32 research outputs found
Association between long-term neuro-toxicities in testicular cancer survivors and polymorphisms in glutathione-s-transferase-P1 and -M1, a retrospective cross sectional study
<p>Abstract</p> <p>Background</p> <p>To assess the impact of polymorphisms in Glutathione S-transferase (GST) -P1, -M1, and -T1 on self-reported chemotherapy-induced long-term toxicities in testicular cancer survivors (TCSs).</p> <p>Methods</p> <p>A total of 238 TCSs, who had received cisplatin-based chemotherapy at median twelve years earlier, had participated in a long-term follow-up survey which assessed the prevalence of self-reported paresthesias in fingers/toes, Raynaud-like phenomena in fingers/toes, tinnitus, and hearing impairment. From all TCSs lymphocyte-derived DNA was analyzed for the functional AâG polymorphism at bp 304 in <it>GSTP1</it>, and deletions in <it>GST-M1 </it>and <it>GST-T1</it>. Evaluation of associations between GST polymorphisms and self-reported toxicities included adjustment for prior treatment.</p> <p>Results</p> <p>All six evaluated toxicities were significantly associated with the cumulative dose of cisplatin and/or bleomycin. Compared to TCSs with either <it>GSTP1-AG </it>or <it>GSTP1</it>-<it>AA</it>, the 37 TCSs with the genotype <it>GSTP1-GG</it>, were significantly less bothered by paresthesias in fingers and toes (p = 0.039, OR 0.46 [0.22â0.96] and p = 0.023, OR 0.42 [0.20â0.88], respectively), and tinnitus (p = 0.008, OR 0.33 [0.14â0.74]). Furthermore, absence of functional GSTM1 protected against hearing impairment (p = 0.025, OR 1.81 [1.08â3.03]).</p> <p>Conclusion</p> <p>In TCSs long-term self-reported chemotherapy-induced toxicities are associated with functional polymorphisms in <it>GSTP1 </it>and <it>GSTM1</it>. Hypothetically, absence of GST-M1 leaves more glutathione as substrate for the co-expressed GST-P1. Also intracellular inactivation of pro-apoptotic mediators represents a possible explanation of our findings. Genotyping of these GSTs might be a welcomed step towards a more individualized treatment of patients with metastatic testicular cancer.</p
In Reply to Revannasiddaiah et al: âLess intense therapy for human papilloma virus associated oropharyngeal carcinoma: Throwing caution to the wind?â
Receptor tyrosine kinase profiles and human papillomavirus status in oropharyngeal squamous cell carcinoma
Phase II study of pemetrexed in combination with cisplatin and cetuximab in recurrent or metastatic squamous cell carcinoma of the head and neck
Kaplan-Meier plot, estimating overall survival.
<p>Differences in survival between the high (interrupted line) and the low (continuous black line) <i>FLT1</i> expression group were analyzed with the log-rank test.</p
Kaplan-Meier plot, estimating overall survival.
<p>Differences in survival between the high (interrupted line) and the low (continuous black line) <i>HPSE</i> expression group were analyzed with the log-rank test.</p
Prognostic role of microRNA polymorphisms in advanced gastric cancer: a translational study of the Arbeitsgemeinschaft Internistische Onkologie (AIO)
Spearman rank correlation between clinicopathological characteristics and dichotomized expression values.
<p>Spearman rank correlation between clinicopathological characteristics and dichotomized expression values.</p
Spearman rank correlation between genes of interest.
<p>Spearman rank correlation between genes of interest.</p