Comparison of ultrasound phacoemulsification and FemtoMatrix® PhotoEmulsification® cataract surgery

ObjectiveTo introduce a novel technology currently under final development before regulatory approvals for the furtherment of cataract surgery, using the FemtoMatrix® laser system, and to demonstrate its safety and efficacy as compared to standard ultrasound phacoemulsification.MethodsThirty-three patients with bilateral cataracts were operated on with one eye undergoing PhotoEmulsification® treatment on the FemtoMatrix® device and the contralateral eye receiving the control procedure, i.e., standard ultrasound phacoemulsification treatment. The number of “zero-phaco” procedures (denoting that I/A alone was sufficient to aspirate the lens fragments and that no ultrasound energy was needed) was recorded and Effective Phaco Time (EPT) values were compared. The patient follow-up was 3 months.ResultsThirty-three eyes from a population with a mean cataract grade of 2.6 were treated on the FemtoMatrix®, of which 29 were “zero-phaco” (88%). All patients were operated on by a single surgeon who was a relative novice to the technology (63 patients treated prior to this study). Conversely, of the 33 fellow eyes who underwent standard ultrasound phacoemulsification, none were zero-phaco (0%) - all required varying degrees of ultrasound energy to make lens aspiration possible. The mean EPT was significantly lower in the PhotoEmulsification® laser group (0.2 ± 0.8 s) than in the phaco group (1.3 ± 1.2 s) (p < 0.0001). The safety profiles of the two procedures were comparable, with no device-related adverse events noted.ConclusionFemtoMatrix® is a promising femtosecond laser platform that, when compared to phacoemulsification, significantly decreases or eliminates EPT altogether. The system is used to perform PhotoEmulsification®, making zero-phaco cataract procedures feasible including in high-grade cataracts (>3). It enables personalized treatment by automatically measuring and adapting the laser energy required to obtain the most efficient cutting of the crystalline lens. This new technology appears to be safe and effective in cataract surgery

Preparation of Oxime HI-6 (Dichloride and Dimethanesulphonate)ŒAntidote against Nerve Agents

Because of the threat of misuse of nerve agents as terroristic weapons by the terrorists, animmediate need is felt for the preparation of antidotes on large-scale basis.  HI-6 (dichloride anddimethanesulphonate) salt are the most promising acetylcholinesterase reactivators used ascausal antidotes in nerve agents intoxication. In this study, rapid and large-scale preparationof oxime HI-6, the most promising reactivator has been described

Diversionary Programs 1 A breakthrough journey for the Top End

This article looks at recent developments in alternative dipute resolution in the NT

Taking Advantage of Reinforcing Fibers in Asphalt Mixture

katedra silničních stave

LASIK Komentovany soubor praci

The principal idea of this project is the assessment of corneal lamellar cut and the following healing process and the clinical application of acquired data. The comparison of lamellar cut with oscillating and rotating microkeratomes was carried out. The oscillating microkeratome Flapmaker (Refractive Technologies) and rotating Dreager microkeratome (Storz) were used for this study. Adhesion of lamella created by the two different microkeratomes was assessed during the healing period of 250 days. Increase of lamella adhesion during the healing period was found. The increase is little faster during the first weeks. The difference in adhesion between eyes operated by different microkeratomes was not significant. The early postoperative adhesion of corneal lamella after LASIK was measured. The interface was washed by water, isotonic and hypertonic saline solution and the influence on the lamella adhesion was assessed. Drying the interface and the excimer laser ablation of epithelial cells along the edge of the lamella were assessed in terms of influence on the adhesion. The term "phototerapeutic epithelectomy (PTE)" was proposed for the excimer laser ablation of corneal epithelial cells. Small insignificant influence of differences in osmolarity of saline solution and little higher but still insignificant influence of PTE were found. The clinical application of PTE to increase the earlier adhesion of lamella is not recommended because of the epithelial destruction along the lamella edge. The adhesion was increased significantly by means of drying the interface which is recommended for clinical application. Diameter and thickness of the lamella were assessed. Rabbit lamella created by the same procedure as human differs significantly and this fact limits the interpretation of rabbit experiments to the human eyes. Oscillating microkeratome Flapmaker created more precise and standard lamella (standard deviation 4 times smaller) compared to rotating Storz on human eyes. Differeces in lamella thickness in different topografical areas of the lamella were 3,3 times smaller with Flapmaker. We conclude that the desired mean lamella thickness and thickness homogenity in different topographical areas of the lamella are much better with Flapmaker compared to Dreager microkeratome on human eyes. Surface of the corneal stroma after microkeratome cut was assessed by classical and environmental SEM. Environmental SEM allows magnification of tissue without it's previous drying. It is easy to prepare tissue for environmental SEM. Disadvantages of this leading technique are smaller scale of magnification and small angle of view. Classical SEM shows better the impact of LASIK on the cornea. Scanning electron microscopy was used to evaluate the differences in the quality of the cut produced by oscillating Flapmaker and rotating Draeger microkeratomes. Higher quality of the edge of the cut was found with Flapmaker. Both units produce uniform surface of the cut. Chatter is much less expressed with Flapmaker. No difference at the interface tissue was found with SEM 3 weeks postoperatively comparing the microkeratomes. Larger diameter of the lamella is preferred. Routine treatment of the lamella edge with phototerapeutic epithelectomy (PTE) is not recommended with Flapmaker. The clinical results of LASIK with two different microkeratomes were evaluated. Operations were performed on two groups of high myopic patients with mean preoperative refraction of -11,09 D sf. eq. and -12,03 D sf. eq. respectively. Faster visual recovery and less complications were found with oscillating microkeratomeAvailable from STL Prague, CZ / NTK - National Technical LibrarySIGLECZCzech Republi

Start Building Your Own Cyber Range – Cyber Arena

The research deals with the importance of education against cyber crimes in today’s world.One of the solutions is through so-called cyber ranges. First two chapters briefly explain the currentproblematic and present some representatives of cyber ranges. The work continues by stress testingof the selected cloud computing platform that is the most suitable for cyber range purposes. Based onthe results, servers/devices are purchased, which form the basis of the future Cyber Arena in BU

Introduction of Cyber Arena

This article describes the current state of a private cyber range named Cyber Arena that is developed by our university. First chapter briefly explains the current problematic and describes the sequence diagram of exemplary communication between the main Cyber Arena components that are OpenStack, ansible AWX, and web-based Training application. Second chapter focuses on Arena architecture and the following chapters briefly explain all mentioned main Arena components