259 research outputs found
The DNA-polymorphism rs849142 is associated with skin toxicity induced by targeted anti-EGFR therapy using cetuximab
Skin toxicity (ST) is a frequent adverse effect (AE) in anti-epidermal growth factor receptor (EGFR)-targeted treatment of metastatic colorectal cancer (mCRC) resulting in decreased quality of life and problems in clinical management. We wanted to identify biomarkers predicting ST in this setting and focused on 70 DNA polymorphisms associated with acne, the (immunoglobulin fragment crystallizable region) Fcγ-receptor pathway, and systemic lupus erythematosus (SLE) applying next-generation-sequencing (NGS). For the analysis patients with mCRC treated with cetuximab were selected from the FIRE-3 study. A training group consisting of the phenotypes low (1) - and high-grade (3) ST (n = 16) and a validation group (n = 55) representing also the intermediate grade (2) were genotyped and investigated in a genotype-phenotype association analysis. The single nucleotide polymorphism (SNP) rs849142 significantly associated with ST in both the training- (p < 0.01) and validation-group (p = 0.04). rs849142 is located in an intron of the juxtaposed with another zinc finger protein 1 (JAZF1) gene. Haplotype analysis demonstrated significant linkage disequilibrium of rs849142 with JAZF1. Thus, rs849142 might be a predictive biomarker for ST in anti-EGFR treated mCRC patients. Its value in the clinical management of AE has to be validated in larger cohorts
On the correct strong-coupling limit in the evolution from BCS superconductivity to Bose-Einstein condensation
We consider the problem of the crossover from BCS superconductivity to
Bose-Einstein condensation in three dimensions for a system of fermions with an
attractive interaction, for which we adopt the simplifying assumption of a
suitably regularized point-contact interaction. We examine in a critical way
the fermionic (self-consistent) T-matrix approximation which has been widely
utilized in the literature to describe this crossover above the superconducting
critical temperature, and show that it fails to yield the correct behaviour of
the system in the strong-coupling limit, where composite bosons form as tightly
bound fermion pairs. We then set up the correct approximation for a ``dilute''
system of composite bosons and show that an entire new class of diagrams has to
be considered in the place of the fermionic T-matrix approximation for the
self-energy. This new class of diagrams correctly describes both the weak- and
strong-coupling limits, and consequently results into an improved interpolation
scheme for the intermediate (crossover) region. In this context, we provide
also a systematic mapping between the corresponding diagrammatic theories for
the composite bosons and the constituent fermions. As a preliminary result to
demonstrate the numerical effect of our new class of diagrams on physical
quantities, we calculate the value of the scattering length for composite
bosons in the strong-coupling limit and show that it is considerably modified
with respect to the result obtained within the self-consistent fermionic
T-matrix approximation.Comment: 25 pages, 14 figures included in pape
Density-induced BCS to Bose-Einstein crossover
We investigate the zero-temperature BCS to Bose-Einstein crossover at the
mean-field level, by driving it with the attractive potential and the particle
density.We emphasize specifically the role played by the particle density in
this crossover.Three different interparticle potentials are considered for the
continuum model in three spatial dimensions, while both s- and d-wave solutions
are analyzed for the attractive (extended) Hubbard model on a two-dimensional
square lattice. For this model the peculiar behavior of the crossover for the
d-wave solution is discussed.In particular, in the strong-coupling limit when
approaching half filling we evidence the occurrence of strong correlations
among antiparallel-spin fermions belonging to different composite bosons, which
give rise to a quasi-long-range antiferromagnetic order in this limit.Comment: 10 pages, 5 enclosed figure
Ginzburg-Landau theory of superconductors with short coherence length
We consider Fermions in two dimensions with an attractive interaction in the
singlet d-wave channel of arbitrary strength. By means of a
Hubbard-Stratonovich transformation a statistical Ginzburg-Landau theory is
derived, which describes the smooth crossover from a weak-coupling BCS
superconductor to a condensate of composite Bosons. Adjusting the interaction
strength to the observed slope of H_c2 at T_c in the optimally doped high-T_c
compounds YBCO and BSCCO, we determine the associated values of the
Ginzburg-Landau correlation length xi and the London penetration depth lambda.
The resulting dimensionless ratio k_F xi(0) approx 5-8 and the Ginzburg-Landau
parameter kappa=lambda xi approx 90-100 agree well with the experimentally
observed values. These parameters indicate that the optimally doped materials
are still on the weak coupling side of the crossover to a Bose regime.Comment: 12 pages, RevTeX, 6 postscript figures, resubmitted with minor
changes in section III, to appear in Physical Review
Pseudogap phase formation in the crossover from Bose-Einstein condensation to BCS superconductivity
A phase diagram for a 2D metal with variable carrier density has been
derived. It consists of a normal phase, where the order parameter is absent; a
so-called ``abnormal normal'' phase where this parameter is also absent but the
mean number of composite bosons (bound pairs) exceeds the mean number of free
fermions; a pseudogap phase where the absolute value of the order parameter
gradually increases but its phase is a random value, and finally a
superconducting (here Berezinskii-Kosterlitz-Thouless) phase. The
characteristic transition temperatures between these phases are found. The
chemical potential and paramagnetic susceptibility behavior as functions of the
fermion density and the temperature are also studied. An attempt is made to
qualitatively compare the resulting phase diagram with the features of
underdoped high- superconducting compounds above their critical
temperature.Comment: 26 pages, revtex, 5 EMTeX figures; more discussion and references
added; to be published in JET
Role of symmetry and dimension on pseudogap phenomena
The attractive Hubbard model in d=2 is studied through Monte Carlo
simulations at intermediate coupling. There is a crossover temperature
where a pseudogap appears with concomitant precursors of Bogoliubov
quasiparticles that are not local pairs. The pseudogap in occurs
in the renormalized classical regime when the correlation length is larger than
the direction-dependent thermal de Broglie wave length, The ratio for the pseudogap may be made
arbitrarily large when the system is close to a point where the order parameter
has SO(n) symmetry with n>2. This is relevant in the context of SO(5) theories
of high but has more general applicability.Comment: 4 pages, LaTeX, 4 epsf figures included. Corrected to agree with
published version. Main change, one new figur
The effect of phase fluctuations on the single-particle properties of the underdoped cuprates
We study the effect of order parameter phase fluctuations on the
single-particle properties of fermions in the underdoped cuprate
superconductors using a phenomenological low-energy theory. We identify the
fermion-phase field coupling as the Doppler-shift of the quasiparticle spectrum
induced by the fluctuating superfluid velocity and we calculate the effect of
these fluctuations on the fermion self-energy. We show that the vortex pair
unbinding near the superconducting transition causes a significant broadening
in the fermion spectral function, producing a pseudogap-like feature. We also
discuss the specific heat and show that the phase fluctuation effect is visible
due to the short coherence length.Comment: RevTex 11 pages; 11 epsf figures included. Added and updated
reference
Shrinking of a condensed fermionic cloud in a trap approaching the BEC limit
We determine the zero-temperature density profile of a cloud of fermionic
atoms in a trap subject to a mutual attractive interaction, as the strength of
the interaction is progressively increased. We find a significant decrease of
the size of the atomic cloud as it evolves from the weak-coupling (BCS) regime
of overlapping Cooper pairs to the strong-coupling (Bose-Einstein) regime of
non-overlapping bound-fermion pairs. Most significantly, we find a pronounced
increase of the value of the density at the center of the trap (even by an
order of magnitude) when evolving between the two regimes. Our results are
based on a generalized Thomas-Fermi approximation for the superfluid state,
that covers continuously all coupling regimes.Comment: 5 pages, 3 postscript figure
Theory of Electric Transport in the Pseudogap State of High-Tc Cuprates
We theoretically investigate the electric transport in the pseudogap state of
High-Tc cuprates. Starting from the repulsive Hubbard model, we perform the
microscopic calculation to describe the pseudogap phenomena which are induced
by the superconducting fluctuations. The single particle Green function, spin
susceptibility and superconducting fluctuations are self-consistently
determined by the SC-FLEX+T-matrix approximation. The longitudinal and
transverse conductivities are calculated by using the Eliashberg and
Kohno-Yamada formalism. The effects of the spin fluctuations and
superconducting fluctuations are estimated, respectively. The vertex
corrections arising from the two fluctuations are also calculated. The
additional contribution from the Aslamazov-Larkin term is also estimated beyond
the Eliashberg formalism.
It is shown that the main effect of the superconducting fluctuations is the
feedback effect through the spin fluctuations. The correct results are obtained
by considering the superconducting fluctuations and the spin fluctuations
simultaneously. The temperature and doping dependences of the resistivity and
the Hall coefficient are well explained. We point out that the characteristic
momentum dependence of the systems plays an essential role in this explanation.Comment: To appear in J. Phys. Soc. Jpn. Vol.71 No.1 (2002
Nonperturbative XY-model approach to strong coupling superconductivity in two and three dimensions
For an electron gas with delta-function attraction we investigate the
crossover from weak- to strong-coupling supercoductivity in two and three
dimensions. We derive analytic expressions for the stiffness of phase
fluctuations and set up effective XY-models which serve to determine
nonperturbatively the temperature of phase decoherence where superconductivity
breaks down. We find the transition temperature T_c as a monotonous function of
the coupling strength and carrier density both in two and three dimensions, and
give analytic formulas for the merging of the temperature of phase decoherence
with the temperature of pair formation in the weak-coupling limit.Comment: Few typos corrected. Emails that were sent to the address
[email protected] in June and July 1999 were lost in a computer crash, so if
your comments were not answered please send them once mor
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