Signal acquisition system

A frequency-tracking feedback circuit for acquiring a communication carrier signal from a relatively noisy environment. The circuit includes a digital phase-frequency detector, a limiter, a mixer, and a voltage-controlled oscillator, connected in a long control loop in such a manner that an input band of signals is translated in frequency until the desired carrier is centered within a relatively narrow acquisition window. The characteristics of the loop are such that acquisition may be achieved even when the total power of the noise in the input signal band exceeds the carrier power, provided that the noise is relatively uniformly distributed over the input band. A technique is also disclosed for compensating from any unbalance in the noise spectrum, so that relatively low carrier-to-noise ratios can be tolerated. Also disclosed are improvements for dynamically varying the parameters of the frequency-tracking loop in such a manner as to reduce acquisition time, and a technique for detecting acquisition and handing control to post-acquisition control circuitry

PcrV Immunization Enhances Survival of Burned Pseudomonas aeruginosa-Infected Mice

Burned Pseudomonas aeruginosa-infected mice immunized against PcrV, a type III virulence system translocating protein, showed significantly enhanced survival compared to controls. Survival was non-O serotype specific and correlated with a reduced systemic microbial load. Infection with a high-level toxin A-producing strain required supplemental antitoxin treatment to enhance survival