1,102 research outputs found

    Chronology of Organizational Structure Changes in a Community College

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    List of Figures: page ii -- Acknowledgements: page vii -- Chapter 1. Introduction: page 1 -- Chapter 2. Methods and Limitations: page 6 -- Chapter 3. History to 1956: page 11 -- Chapter 4. Organization Structures 1956-1962: page 16 -- Chapter 5. Organization Structures 1962-1972: page 32 -- Chapter 6. Organization Structures 1972-1977: page 47 -- Chapter 7. Organization Structures 1977-1980: page 67 -- Chapter 8. Epilogue 1984: page 92 -- Glossary: page 97 -- Bibliography: page 10

    Concerns Affecting Computer Usage by County Extension Educators in Florida

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    The Florida Cooperative Extension Service continues to develop and provide information to extension educators and their clientele via computer

    Editorial: teaching social and behavioural sciences in medical education

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    This article was migrated. The article was marked as recommended. Not applicable.</ns4:p

    Clinical Significance of the Integrin α6β4 in Human Malignancies

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    Integrin α6β4 is a cellular adhesion molecule that binds to laminins in the extracellular matrix and nucleates the formation of hemidesmosomes. During carcinoma progression, integrin α6β4 is released from hemidesmosomes, where it can then signal to facilitate multiple aspects of tumor progression including sustaining proliferative signaling, tumor invasion and metastasis, evasion of apoptosis, and stimulation of angiogenesis. The integrin achieves these ends by cooperating with growth factor receptors including EGFR, ErbB-2, and c-Met to amplify downstream pathways such as PI3K, AKT, MAPK, and the Rho family small GTPases. Furthermore, it dramatically alters the transcriptome toward a more invasive phenotype by controlling promoter DNA demethylation of invasion and metastasis-associated proteins, such as S100A4 and autotaxin, and upregulates and activates key tumor-promoting transcription factors such as the NFATs and NF-κB. Expression of integrin α6β4 has been studied in many human malignancies where its overexpression is associated with aggressive behavior and a poor prognosis. This review provides an assessment of integrin α6β4 expression patterns and their prognostic significance in human malignancies, and describes key signaling functions of integrin α6β4 that contribute to tumor progression

    Establishment and functions of DNA methylation in the germline.

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    Epigenetic modifications established during gametogenesis regulate transcription and other nuclear processes in gametes, but also have influences in the zygote, embryo and postnatal life. This is best understood for DNA methylation which, established at discrete regions of the oocyte and sperm genomes, governs genomic imprinting. In this review, we describe how imprinting has informed our understanding of de novo DNA methylation mechanisms, highlight how recent genome-wide profiling studies have provided unprecedented insights into establishment of the sperm and oocyte methylomes and consider the fate and function of gametic methylation and other epigenetic modifications after fertilization

    Spatiotemporal Semantics and Moving Objects Research

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    University of IowaPlatinum Sponsors * KU Transportation Research Institute Gold Sponsors * KU Department of Geography * KU Institute for Policy & Social Research * State of Kansas Data Access and Support Center (DASC) * KU Libraries GIS and Scholar Services * Wilson & Company Engineers and Architects Silver Sponsors * Bartlett & West * KansasView Consortium * KU Biodiversity Institute Bronze Sponsors * AECOM * Kansas Biological Survey * C-CHANGE Program (NSF IGERT) * KU Environmental Studies Program * KU Department of Ecology and Evolutionary Biology * Mid-West CAD * National Weather Service * Spatial Data Researc

    Textile Properties of Men’s Athletic Pants

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    Sydney Aulds is an undergraduate student in the School of Human Ecology at Louisiana Tech University. Emerald Clark is an undergraduate student in the School of Human Ecology at Louisiana Tech University. Torie Stewart is an undergraduate student in the School of Human Ecology at Louisiana Tech University. Kathleen Heiden is an Associate Professor in the School of Human Ecology at Louisiana Tech University

    Life Skill Needs of Occupational Therapy Assistant Students: Perceptions of Instructors, Preceptors, Graduates and Current Students

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    Life skills are the basic skills required to function in everyday life. Occupational therapy assistant (OTA) students may struggle with life skills, and as a result experience challenges in academics and practicum. The purpose of this phase of a multiphase study was to identify the life skill needs of OTA students from multiple perspectives. This study used a pragmatic qualitative design. Students in the second year of a 2-year therapy assistant diploma program, graduates, instructors, and preceptors participated in interviews or focus groups to discuss OTA students’ life skill needs. Interviews and focus groups were recorded and transcribed. Applied thematic analysis was used to analyze the interview and focus group data and draw conclusions. Common themes were identified: contributors to student success; impact of students’ life skills on clinical encounters; and life skills training needs. These themes were identified across all participant groups. Findings suggest that OTA students with lower confidence or abilities in life skills may also have lower confidence and success in clinical encounters. Life skills training tailored to OTA students may help students develop foundational skills to enhance their confidence and competence in relevant life skill areas
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