1,141 research outputs found

    Mounting Books Project

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    4th International Conference on Open RepositoriesThis presentation was part of the session : Conference PresentationsDate: 2009-05-19 03:00 PM – 04:30 PMThe Northwestern University Library undertook a software development project to create an automated workflow to enable files from its Kirtas book scanner to be both linked to the OPAC with a page viewer application, and ingested into its Fedora repository as archivally sustainable and reusable digital objects. The web-based Book Workflow Interface (BWI) software utilizes jBPM for management and web services for key creation components. It also features an AJAX interface to support drag-and-drop creation and editing of METS-based book structures. The BWI system ingests locally scanned texts as well as texts digitized by external partners or vendors. This project addressed the need for a Fedora-based book viewing tool that can be used by other research libraries developing digital repositories based on a Fedora systems architecture. The book view interface includes full-text search and view, search-within-a-book, book structure browse, page turning, and zooming interface components. The workflow system can be expanded over time to support new functions in the book publishing process, and can be redeployed in support of digitization processes for other types of media. Shifting from a simple book reformatting operation to a dynamic program that makes any multipage text object fully accessible online, this system dramatically improves Northwestern's ability to share its unique library and archival collections. The project was fully supported by the Andrew W. Mellon Foundation and the Book Workflow Interface and public book viewing software will both be released as open source in spring 2009.Andrew W. Mellon Foundatio

    The placebo puzzle: Putting together the pieces

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    Placebo psychotherapies and nonconscious learning in the placebo effect: Reply to Kirsch (2004)

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    THE VALUE OF THE VIEW: VALUING SCENIC QUALITY USING CHOICE AND CONTINGENT VALUATION MODELS

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    Scenic beauty contributes to residents' quality of life and also serves to attract visitors to recreational areas. Because of the dynamic relationship between people, land, and rural development, there is an increasing interest in estimating the value of scenic quality using nonmarket valuation techniques. This study estimates the value of scenic quality to Blue Ridge Parkway visitors using choice and contingent valuation models. Results suggest that further research into respondent perceptions of CM and CVM models, and the conditions under which they yield comparable estimates, is warranted.Institutional and Behavioral Economics,

    The ape that kicked the hornet's nest: Response to commentaries on "The Ape that Thought It Was a Peacock"

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    We respond to the commentaries on our target article, The Ape that Thought It Was a Peacock. We start with specific issues raised by the article. These relate to the magnitude of human sex differences; the evolution and relative importance of pair bonding, paternal care, and polygyny in our species; and the distinction between the males-compete/females-choose (MCFC) model of human sexual psychology and the mutual mate choice (MMC) model. We then evaluate two competing theories of human sex differences and similarities: Social Role Theory and Attachment Fertility Theory. We conclude with some thoughts about how to present and teach evolutionary psychological research and theories without conveying an exaggerated impression of the scale of human sex differences

    Restoration Preferences and Management for the Middle Rio Grande

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    River restoration efforts typically receive broad public support. However, standing questions include whether restoration efforts are worth it in the sense that benefits outweigh the costs, whether some types of restoration are more beneficial than others, and how restoration efforts were ultimately received by the public they serve. This research identifies restoration metrics to quantify physical changes that will actually take place, and uses econometric methodology to determine how human well-being will be improved from these changes. Restoration decisions have much to gain from improved information; funding is strong with more than $10 billion spent nationally on over 35,000 such projects (NRRSS, 2005). Ongoing restoration by the US Army Corps of Engineers in the Albuquerque reach of the Middle Rio Grande Bosque is used as a vehicle to investigate public restoration values. A mail survey conducted in 2005-2006 explores visitation statistics and potential recreation improvements. The survey also partitions use and non-use values for the ecosystem as a whole. Restoration valuation focuses on four key restoration attributes identified by focus groups: Fish and Wildlife Habitat; Vegetation Density; Tree Type; and Natural River Processes. A choice model is used to decompose the value of these restoration attributes in both a relative and absolute (dollar) sense. Results are applicable to other southwestern riparian areas with qualifications for site-specific factors. The long-range goal associated with this work it to address data needs for a dynamic simulation model of Total Riparian Value. This Total Riparian Value model is itself a component of a larger watershed decision support tool, being developed by a Sandia National Laboratories-directed team

    GABA-B controls persistent Na+ current and coupled Na+-activated K+ current

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    AbstractThe GABA-B receptor is densely expressed throughout the brain and has been implicated in many CNS functions and disorders, including addiction, epilepsy, spasticity, schizophrenia, anxiety, cognitive deficits, and depression, as well as various aspects of nervous system development. How one GABA-B receptor is involved in so many aspects of CNS function remains unanswered. Activation of GABA-B receptors is normally thought to produce inhibitory responses in the nervous system, but puzzling contradictory responses exist. Here we report that in rat mitral cells of the olfactory bulb, GABA-B receptor activation inhibits both the persistent sodium current (INaP) and the sodium-activated potassium current (IKNa), which is coupled to it. We find that the primary effect of GABA-B activation is to inhibit INaP, which has the secondary effect of inhibiting IKNabecause of its dependence on persistent sodium entry for activation. This can have either a net excitatory or inhibitory effect depending on the balance of INaP/IKNacurrents in neurons. In the olfactory bulb, the cell bodies of mitral cells are densely packed with sodium-activated potassium channels. These channels produce a large IKNawhich, if constitutively active, would shunt any synaptic potentials traversing the soma before reaching the spike initiation zone. However, GABA-B receptor activation might have the net effect of reducing the IKNablocking effect, thus enhancing the effectiveness of synaptic potentials.</jats:p

    Health Effects of Indoor-Air Benzene in Anchorage Residences: A Study of Indoor-Air Quality in Houses with Attached Garages

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    Benzene is a known carcinogen. It affects white blood cells; it causes leukemia and aplastic anemia. It may also affect the immune system which is dependent on white blood cells.1 It has been removed from all household products, but it is still present in gasoline. Alaskan gasoline is particularly high in benzene (>5%). Gasoline refined in Alaska has high concentrations of benzene and other the aromatic compounds as much as 50% aromatics by volume. Leaving the aromatics in the gasoline helps cars start in the cold, but it also puts high concentrations of benzene in both the ambient and indoor air. We already knew from previous work done in Alaska by Bernard Goldstein in Valdez2 and the Anchorage Department of Health and Human Services in Anchorage3 that people were exposed to high ambient levels of benzene in the winter, and that there were high indoor benzene concentrations in homes with attached garages if the garage was used to store gasoline or gasoline powered engines. Benzene does not bioaccumulate in the body as dioxin or some pesticides do. But are its effects cumulative? Does a little dose of benzene everyday have the same effect as a large dose over less time? Benzene reduces CD4 cells in a dose-response manner at workplace concentrations less than 1 ppm (OSHA 8-hour exposure limit) in workers.4 People who live in homes with high benzene concentrations may be exposed 24 hours a day, seven days a week. There have been no studies of health effects of such environmental exposure to benzene. This study was done to determine three things: 1. What percentage of Anchorage homes with attached garages had high levels of indoor benzene? 2. Were the high levels of indoor benzene affecting the health of the residents? 3. Were residents more likely to develop asthma in homes with high levels of indoor benzene?Municipality of AnchorageIntroduction / Methods / Recruitment / Results / Laboratory Results / Smoking / Health Results / Demographics / Determining Risk Levels / Asthma Outcomes / Children / Work and Hobby Exposure / General Health / Conclusions / Bibliography / Appendice
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