Oral Argument in Meyer v. Holley (No. 01-1120)

The matter of Meyer v. Holley, 537 U.S. 280 (2003) was argued before the United States Supreme Court on Tuesday, December 3, 2002. Professor Robert G. Schwemm argued on behalf of the Respondents. This document is a transcript of the oral argument

Cytotoxicity of Atriplex confertifolia

The search for cancer treatment continues to be a global effort. As part of this global effort, many natural products have been tested against cancer cell lines, mostly from tropically located plants. This study reports that extracts of Atriplex confertifolia (Torr. and Frem.) S. Watson (Chenopodiaceae), a native North American plant (also known as shadscale or saltbush), has significant bioactivity against human breast cancer cell lines MCF-7, MDA-MB 435, MDA-MB 231, and HeLa cells (cervical cancer cells). The bioactivity of A. confertifolia extracts on these cells lines was compared to an FDA-approved cancer drug (Onxol®) and an industry-standard leukocyte control cell line. Active portions of the extracts were found primarily in the polar fractions of the plant. A dose-response curve of the extracts displayed significant cell death similar to Onxol®. The plant extracts did not significantly inhibit the viability of the leukocyte cell line. In a timed study, over 90% of cell lines MDA-MB 435 and HeLa died after 24 hours. Cell death appears to result from apoptosis

Brief for the United States as Amicus Curiae in Support of Neither Party

Amicus ("friend of the court") brief written by the United States in support of petitioners in AMP v. Myriad Genetics (Supreme Court Case Docket No. 12-398)

CAD bash: accelerating 2D/3D computer aided design competencies for first year product design students

The everchanging technological and digital landscape of the Product Design and Product Design Engineering industry now requires graduates to have a wider range of skills and software knowledge. In particular, there is a need for enhanced skills focused on engineering computer aided design (CAD), virtual reality, 3D visualisation and rendering/animation. This has resulted in graduates requiring a more detailed and rigorous CAD and 3D visualisation syllabus to prepare them adequately for industry. With the increased pressures on delivering a wider range of software teaching alongside a greater range of hardware, the need for a good grounding and understanding of 2D/3D engineering CAD competencies is essential. Subsequently we have identified the need for enhanced engineering CAD teaching and learning within the higher education setting especially within the first-year product design curriculum. As such, there is the need to challenge established pedagogy and delivery methods with regards to CAD tuition in order to explore new delivery methods and alternative educational paradigms to allow educators to equip engineers and designers for future industry requirements. To enhance the CAD skills of product design students, the product design academic team at Nottingham Trent University have sought to accelerate the learning of core 2D/3D engineering CAD competencies within first year students by providing an accelerated learning program focussed on SolidWorks. This paper explores and reflects on the development of a ‘CAD Bash’, an accelerated teaching block of 2D/3D engineering CAD, utilizing SolidWorks and delivered in week two of the first year product design students higher education journey. Sixty-Two BSc Product Design first year students undertook eight 1.5-2-hour sessions over the course of a 15-hour accelerated synchronous teaching block during a single week. CAD Bash synchronous teaching was also supported by asynchronous content in the form of pre-recorded videos and prepared worksheets/guides. Prior to commencing ‘CAD Bash’, each student completed a Pre-CAD Bash skills audit to ascertain the student cohorts’ current knowledge/understanding of software programs, situated within Engineering CAD, such as SolidWorks. This survey helped inform the tutors on student prior knowledge allowing adjustments to the level of learning/content delivered. A Post-CAD Bash skills audit was then collected, providing insight into the effectiveness of the accelerated teaching block, thus informing CAD tuition for the remainder of the academic year. This paper also presents student feedback and the findings from CAD Bash to demonstrate the effectiveness and impact of an accelerated CAD teaching block focused on fundamental engineering CAD competencies. Finally, this paper will demonstrate how the delivery of an entire term’s worth of CAD tuition within a single week period not only prepared students better for future CAD learning but has also created room within the CAD syllabus to teach a wider range of software in more depth. Subsequently this has enhanced our entire three-year CAD syllabus for product design students and positively impacted student skill level thus providing greater placement and graduate opportunities in the future

HopScotch - a low-power renewable energy base station network for rural broadband access

The provision of adequate broadband access to communities in sparsely populated rural areas has in the past been severely restricted. In this paper, we present a wireless broadband access test bed running in the Scottish Highlands and Islands which is based on a relay network of low-power base stations. Base stations are powered by a combination of renewable sources creating a low cost and scalable solution suitable for community ownership. The use of the 5~GHz bands allows the network to offer large data rates and the testing of ultra high frequency ``white space'' bands allow expansive coverage whilst reducing the number of base stations or required transmission power. We argue that the reliance on renewable power and the intelligent use of frequency bands makes this approach an economic green radio technology which can address the problem of rural broadband access

Effective action and motion of a cosmic string

We examine the leading order corrections to the Nambu effective action for the motion of a cosmic string, which appear at fourth order in the ratio of the width to radius of curvature of the string. We determine the numerical coefficients of these extrinsic curvature corrections, and derive the equations of motion of the worldsheet. Using these equations, we calculate the corrections to the motion of a collapsing loop, a travelling wave, and a helical breather. From the numerical coefficients we have calculated, we discuss whether the string motion can be labelled as `rigid' or `antirigid,' and hence whether cusp or kink formation might be suppressed or enhanced.Comment: 24 pages revtex, 12 figure

Animal models of chemotherapy-induced peripheral neuropathy:a machine-assisted systematic review and meta-analysis

<div><p>We report a systematic review and meta-analysis of research using animal models of chemotherapy-induced peripheral neuropathy (CIPN). We systematically searched 5 online databases in September 2012 and updated the search in November 2015 using machine learning and text mining to reduce the screening for inclusion workload and improve accuracy. For each comparison, we calculated a standardised mean difference (SMD) effect size, and then combined effects in a random-effects meta-analysis. We assessed the impact of study design factors and reporting of measures to reduce risks of bias. We present power analyses for the most frequently reported behavioural tests; 337 publications were included. Most studies (84%) used male animals only. The most frequently reported outcome measure was evoked limb withdrawal in response to mechanical monofilaments. There was modest reporting of measures to reduce risks of bias. The number of animals required to obtain 80% power with a significance level of 0.05 varied substantially across behavioural tests. In this comprehensive summary of the use of animal models of CIPN, we have identified areas in which the value of preclinical CIPN studies might be increased. Using both sexes of animals in the modelling of CIPN, ensuring that outcome measures align with those most relevant in the clinic, and the animal’s pain contextualised ethology will likely improve external validity. Measures to reduce risk of bias should be employed to increase the internal validity of studies. Different outcome measures have different statistical power, and this can refine our approaches in the modelling of CIPN.</p></div

Identification of the first ATRIP-deficient patient and novel mutations in ATR define a clinical spectrum for ATR-ATRIP Seckel Syndrome

A homozygous mutational change in the Ataxia-Telangiectasia and RAD3 related (ATR) gene was previously reported in two related families displaying Seckel Syndrome (SS). Here, we provide the first identification of a Seckel Syndrome patient with mutations in ATRIP, the gene encoding ATR-Interacting Protein (ATRIP), the partner protein of ATR required for ATR stability and recruitment to the site of DNA damage. The patient has compound heterozygous mutations in ATRIP resulting in reduced ATRIP and ATR expression. A nonsense mutational change in one ATRIP allele results in a C-terminal truncated protein, which impairs ATR-ATRIP interaction; the other allele is abnormally spliced. We additionally describe two further unrelated patients native to the UK with the same novel, heterozygous mutations in ATR, which cause dramatically reduced ATR expression. All patient-derived cells showed defective DNA damage responses that can be attributed to impaired ATR-ATRIP function. Seckel Syndrome is characterised by microcephaly and growth delay, features also displayed by several related disorders including Majewski (microcephalic) osteodysplastic primordial dwarfism (MOPD) type II and Meier-Gorlin Syndrome (MGS). The identification of an ATRIP-deficient patient provides a novel genetic defect for Seckel Syndrome. Coupled with the identification of further ATR-deficient patients, our findings allow a spectrum of clinical features that can be ascribed to the ATR-ATRIP deficient sub-class of Seckel Syndrome. ATR-ATRIP patients are characterised by extremely severe microcephaly and growth delay, microtia (small ears), micrognathia (small and receding chin), and dental crowding. While aberrant bone development was mild in the original ATR-SS patient, some of the patients described here display skeletal abnormalities including, in one patient, small patellae, a feature characteristically observed in Meier-Gorlin Syndrome. Collectively, our analysis exposes an overlapping clinical manifestation between the disorders but allows an expanded spectrum of clinical features for ATR-ATRIP Seckel Syndrome to be define