The Health Status and Unique Health Challenges of Rural Older Adults in California

Examines the demographics, health, and levels of physical activity and food insecurity of rural seniors compared with those of urban and suburban seniors. Outlines environmental and social risk factors that require context-specific policies and programs

Gesture use in children with autism spectrum disorder: a scoping review

Purpose This study reviewed the literature examining type and frequency of gesture use in children diagnosed with autism spectrum disorder (ASD) in comparison to other populations. The findings can inform future studies and programs targeting the use of gestures as an early indicator of ASD. Methods A six step search procedure was utilized to identify all articles exploring gesture use in children with ASD in comparison to other populations. Articles meeting inclusion criteria were double coded by the investigators with 97% agreement. Results examining type and frequency of gesture were synthesized and three common themes were identified: comparison group(s), age of participants with ASD, and gesture terminology. Results A total of 32 studies met inclusion criteria for this study. Of these studies, nine exclusively measured type of gesture, 17 exclusively measured frequency, and 6 measured both type and frequency. Results indicate that children with ASD used different types and frequency of gesture in comparison to other populations. The most studied age range was 4–5 years and most studies used typically developing children as the comparison group. Gesture terminology and definition were extremely variable. Conclusions Children with ASD are using different types and frequencies of gesture when compared to other populations. More research including younger and more diverse populations is needed to translate these findings into clinical practice. Additionally, there is a need for more consistent use of gesture terminology and definition

Autism Spectrum Disorder Screening Practices in the United States and Mexico

Purpose: The purpose of this study was to explore screening practices for autism spectrum disorder (ASD) in Mexico and the United States (U.S.). Methods: Data from a larger study exploring the knowledge, screening, and diagnostic practices of healthcare practitioners from Mexico and the U.S. was used for the current study. The original survey was created by experts in ASD and consisted of 63 questions: 15 demographic questions, 20 questions relating to knowledge of ASD, 11 questions relating to screening practices, and 17 questions relating to diagnostic practices. All surveys were completed by professionals engaging in the screening and diagnosis of ASD. For this study, a total of thirty- five survey responses for the screening portion of the survey (30 from the U.S. and 5 from Mexico) were explored. Qualitative data and descriptive statistics were utilized. Results: Many of the responses relating to screening practices from professionals practicing in Mexico and the U.S. were consistent with best practice guidelines from the Centers for Disease Control and Prevention (CDC), the American Academy of Pediatrics (AAP), and the Mexican Public Health Guide. Furthermore, many similarities were found in the screening practices of professionals from both countries. Differences in screening practices reported by professionals from Mexico and the U.S. were found in the type of professional involved in the screening process and professional referrals after a failed ASD screening. Additionally, some professionals from both the U.S. and Mexico reported the use of inappropriate screening tools, and the average age reportedly screened was much higher than the current recommendations of the American Academy of Pediatrics (Hyman et al., 2020). Conclusion: An understanding of the screening practices currently being used in Mexico and the U.S. provides both researchers and clinicians with a better understanding of what is being implemented by different professionals. This study identified areas of strength and areas of weaknesses in the screening process for ASD in both countries. These results can now be used in future studies and programs targeting improved screening processes in Mexico in the U.S. Improved screening processes are important because of the potential to result in an earlier age of diagnosis of ASD and provision of services at a younger age. The latter of which is associated with better outcomes for children with ASD

Professional Perspectives on Bilingualism in Persons with Autism Spectrum Disorder: A Pilot Study

Purpose: The present study examined the perspectives of professionals regarding bilingualism and ASD. Methods: A total of 27 professionals participated in this study. Data was collected via an online survey. The survey was designed based on a literature review and consultation with a team of experts in the field of ASD. Information relating to demographic information, professional practice information, and perspectives of bilingualism and ASD was collected. Results: Professionals participating in the present study were most likely to agree with the statement, “A child with ASD from a bilingual household is able to understand both languages” and least likely to agree with the statement, “There are enough bilingual service providers and resources.” Responses to 5 of the 8 statements related to professional perspectives on bilingualism in children with ASD were near the scale midpoint indicating the participants did not strongly agree nor disagree with the perceptions. When asked what language parents should speak to their children with ASD from a bilingual household, 44% of participants recommended a bilingual approach, and 30% indicated a monolingual approach. Participants reported professional experience and the ability to communicate with caregivers/others in the environment/parent language use as influences for these recommendations. Furthermore, sex, level of education, and bilingual caseload were found to be significantly related to perspectives on bilingualism and ASD. Conclusion: The results of this study support previous literature which has identified a disconnect between research and clinical practice regarding bilingualism and ASD. Furthermore, the relationship between specific demographic and professional variables found in this study can now be used by future research studies and programs targeting bilingualism and ASD. These findings are of particular importance when considering that research has supported bilingualism in children with ASD, yet many professionals continue to implement a monolingual approach. A better understanding of professional perspectives of bilingualism in ASD provides insight into the discrepancy between research and clinical practice and paves the way for future studies and programs targeting improved services for bilingual children with ASD

Professional Perspectives on Bilingualism in Persons with Autism Spectrum Disorder: A Pilot Study

Purpose: The present study examined the perspectives of professionals regarding bilingualism and ASD. Methods: A total of 27 professionals participated in this study. Data was collected via an online survey. The survey was designed based on a literature review and consultation with a team of experts in the field of ASD. Information relating to demographic information, professional practice information, and perspectives of bilingualism and ASD was collected. Results: Professionals participating in the present study were most likely to agree with the statement, “A child with ASD from a bilingual household is able to understand both languages” and least likely to agree with the statement, “There are enough bilingual service providers and resources.” Responses to 5 of the 8 statements related to professional perspectives on bilingualism in children with ASD were near the scale midpoint indicating the participants did not strongly agree nor disagree with the perceptions. When asked what language parents should speak to their children with ASD from a bilingual household, 44% of participants recommended a bilingual approach, and 30% indicated a monolingual approach. Participants reported professional experience and the ability to communicate with caregivers/others in the environment/parent language use as influences for these recommendations. Furthermore, sex, level of education, and bilingual caseload were found to be significantly related to perspectives on bilingualism and ASD. Conclusion: The results of this study support previous literature which has identified a disconnect between research and clinical practice regarding bilingualism and ASD. Furthermore, the relationship between specific demographic and professional variables found in this study can now be used by future research studies and programs targeting bilingualism and ASD. These findings are of particular importance when considering that research has supported bilingualism in children with ASD, yet many professionals continue to implement a monolingual approach. A better understanding of professional perspectives of bilingualism in ASD provides insight into the discrepancy between research and clinical practice and paves the way for future studies and programs targeting improved services for bilingual children with ASD

Pluralism about Knowledge

In this paper I consider the prospects for pluralism about knowledge, that is, the view that there is a plurality of knowledge relations. After a brief overview of some views that entail a sort of pluralism about knowledge, I focus on a particular kind of knowledge pluralism I call standards pluralism. Put roughly, standards pluralism is the view that one never knows anything simpliciter. Rather, one knows by this-or-that epistemic standard. Because there is a plurality of epistemic standards, there is a plurality of knowledge relations. In §1 I argue that one can construct an impressive case for standards pluralism. In §2 I clarify the relationship between standards pluralism, epistemic contextualism and epistemic relativism. In §3 I argue that standards pluralism faces a serious objection. The gist of the objection is that standards pluralism is incompatible with plausible claims about the normative role of knowledge. In §4 I finish by sketching the form that a standards pluralist response to this objection might take

Differential gene expression in response to fungal pathogen exposure in the aquatic invertebrate, 'Daphnia dentifera'

While vertebrate immune systems are appreciated for their complexity and adaptability, invertebrate immunity is often considered to be less complex. However, immune responses in many invertebrates likely involve sophisticated processes. Interactions between the crustacean host Daphnia dentifera and its fungal pathogen Metschnikowia bicuspidata provide an excellent model for exploring the mechanisms underlying crustacean immunity. To explore the genomic basis of immunity in Daphnia, we used RNA‐sequencing technology to quantify differential gene expression between individuals of a single host genotype exposed or unexposed to M. bicuspidata over 24 h. Transcriptomic analyses showed that the number of differentially expressed genes between the control (unexposed) and experimental (exposed) groups increased over time. Gene ontology enrichment analysis revealed that differentially expressed genes were enriched for immune‐related molecules and processes, such as cuticle development, prostaglandin, and defense response processes. Our findings provide a suite of immunologically relevant genes and suggest the presence of a rapidly upregulated immune response involving the cuticle in Daphnia. Studies involving gene expression responses to pathogen exposure shine a light on the processes occurring during the course of infection. By leveraging knowledge on the genetic basis for immunity, immune mechanisms can be more thoroughly understood to refine our understanding of disease spread within invertebrate populations.Published versio

A genetic modifier suggests that endurance exercise exacerbates Huntington's disease.

Polyglutamine expansions in the huntingtin gene cause Huntington's disease (HD). Huntingtin is ubiquitously expressed, leading to pathological alterations also in peripheral organs. Variations in the length of the polyglutamine tract explain up to 70% of the age-at-onset variance, with the rest of the variance attributed to genetic and environmental modifiers. To identify novel disease modifiers, we performed an unbiased mutagenesis screen on an HD mouse model, identifying a mutation in the skeletal muscle voltage-gated sodium channel (Scn4a, termed 'draggen' mutation) as a novel disease enhancer. Double mutant mice (HD; Scn4aDgn/+) had decreased survival, weight loss and muscle atrophy. Expression patterns show that the main tissue affected is skeletal muscle. Intriguingly, muscles from HD; Scn4aDgn/+ mice showed adaptive changes similar to those found in endurance exercise, including AMPK activation, fibre type switching and upregulation of mitochondrial biogenesis. Therefore, we evaluated the effects of endurance training on HD mice. Crucially, this training regime also led to detrimental effects on HD mice. Overall, these results reveal a novel role for skeletal muscle in modulating systemic HD pathogenesis, suggesting that some forms of physical exercise could be deleterious in neurodegeneration