Invertebrate Fauna of Devils Den, a Sandstone Cave in Northwestern Arkansas

The same invertebrate fauna of 17 species was found in Devils Den Cave, Washington County, Arkansas, in 1969 and 1979. The fauna consists of 1 trogloxene, 14 troglophiles, and 2 troglobites, a spider, Porrhomma cavernicolum, and a collembolan, Pseudosinella dubia. Devils Den Cave has a well developed cavernicolous fauna, although it is in sandstone which generally supports a poor cave adapted fauna. The troglobites probably evolved in the vicinity of northwestern Arkansas in limestone caves or in deep forest soils of the Ozark region. They then dispersed overland, perhaps as recently as the late Wisconsinan, to occupy this sandstone cave

Alien Registration- Stewart, James H. (Pittsfield, Somerset County)

https://digitalmaine.com/alien_docs/6415/thumbnail.jp

Substrate Specificity of Human Cutaneous Alcohol Dehydrogenase and Erythema Provoked by Lower Aliphatic Alcohols

The substrate utilization rates of human cutaneous alcohol dehydrogenase were determined for 7 lower aliphatic primary alcohols: ethanol, propanol, butanol, pentanol, 2-methylpropanol, 3-methylbutanol, and 2,2-dimethylpropanol. 1-Pentanol gave the highest relative activity and 2,2-dimethyipropanol the lowest. The frequency of erythemogenesis was determined in vivo for these 7 lower aliphatic primary alcohols. The frequency of erythemogenesis correlated strongly and significantly with the rate of substrate utilization by alcohol dehydrogenase. These results are consistent with the view that the reaction to primary alcohols applied topically to human skin is provoked, in large part, by the corresponding aldehyde

Efficacy, safety, and improved tolerability of travoprost BAK-free ophthalmic solution compared with prior prostaglandin therapy

J Charles Henry1, James H Peace2, Jeanette A Stewart3,4, William C Stewart3,41Little Rock Eye Clinic, Little Rock, AR, USA; 2Diabetic Eye Medical Clinic, Inglewood, CA, USA; 3PRN Pharmaceutical Research Network, LLC, Dallas,TX, USA; 4Carolina Eye Institute, University of South Carolina, School of Medicine, Columbia, SC, USAPurpose: To evaluate the efficacy, safety and tolerability of changing to travoprost BAK-free from prior prostaglandin therapy in patients with primary open-angle glaucoma or ocular hypertension.Design: Prospective, multi-center, historical control study.Methods: Patients treated with latanoprost or bimatoprost who needed alternative therapy due to tolerability issues were enrolled. Patients were surveyed using the Ocular Surface Disease Index (OSDI) to evaluate OSD symptoms prior to changing to travoprost BAK-free dosed once every evening. Patients were re-evaluated 3 months later.Results: In 691 patients, travoprost BAK-free demonstrated improved mean OSDI scores compared to either latanoprost or bimatoprost (p < 0.0001). Patients having any baseline OSD symptoms (n = 235) demonstrated significant improvement after switching to travoprost BAK-free (p < 0.0001). In 70.2% of these patients, symptoms were reduced in severity by at least 1 level. After changing medications to travoprost BAK-free, mean intraocular pressure (IOP) was significantly decreased (p < 0.0001). Overall, 72.4% preferred travoprost BAK-free (p < 0.0001, travoprost BAK-free vs prior therapy). Travoprost BAK-free demonstrated less conjunctival hyperemia than either prior therapy (p < 0.0001).Conclusions: Patients previously treated with a BAK-preserved prostaglandin analog who are changed to travoprost BAK-free have clinically and statistically significant improvement in their OSD symptoms, decreased hyperemia, and equal or better IOP control.Keywords: glaucoma, prostaglandin analog, travoprost, latanoprost, bimatoprost, preservative, benzalkonium chloride, ocular surface diseas

30 Years of Cystocele/Rectocele Repair in the United States

Objective: A growing body of evidence suggests an increased role for apical support in the treatment of pelvic organ prolapse regardless of phenotype. The objective of this study was to determine whether changes in cystocele/rectocele diagnosis and surgical management for the last 30 years reflect this changing paradigm. Methods: Data from the National Hospital Discharge Survey were mined from 1979 to 2009 for diagnosis and procedure codes. Records were categorized according to predefined combinations of diagnosis and procedure codes and weighted according to the National Hospital Discharge Survey data set. Pearson [chi]2 test was used to evaluate the changes in population proportions during the study interval. Results: The proportion of isolated cystocele/rectocele diagnoses decreased from 1979 to 2009 (56.5%, n = 88,548, to 34.8%, n = 31,577). The proportion of isolated apical defect diagnoses increased from 1979 to 2009 (38.4%, n = 60,223, to 60.8%, n = 55,153). There was a decrease in the frequency of isolated cystocele/rectocele repair procedures performed from 1979 to 2009 (96.3%, n = 150,980, to 67.7%, n = 61,444), whereas there was an increase in isolated apical defect repair procedures (2.5%, n = 3929, to 22.5%, n = 20,450). The proportion of cystocele/rectocele plus apical defect procedures also increased (1.2%, n = 1879, to 9.7%, n = 8806). Furthermore, 87.0% of all studied diagnostic groups were managed by cystocele/rectocele repair alone. Conclusions: Surgeons have responded to the increased contribution of apical support defects to cystocele/rectocele by modifying their diagnostic coding practices. Unfortunately, their surgical choices remain largely rooted in an older paradigm

Seeing What's Not THere: The Enigma of Entrepreneurship

The process is clear: entrepreneurs initiate business ventures. What is not clear is why they do so. The debate continues to rage about entrepreneurial behavior and this singular act of individual volition which is so vital to a nation's economic health and well being. The drives and personalities continue to be debated. Gartner (1988) asks, "Can one know the dancer from the dance?"  Is it even important to try? Carland, Hoy and Carland (I 988) think it is essential because one cannot understand the dance without  understanding the dancer.We think that the dance takes on the personality of the dancer. It is the dancer who interprets the dance and each artist makes the process his or her own. If we seek to understand the entrepreneurial process, we must have some insight into the entrepreneurial psyche. This is especially true if we wish to design educational and training programs for prospective and practicing entrepreneurs.In this work, we empirically examine 502 owner/managers of small businesses. We identify entrepreneurial vision, the ability to see what is not there, as their commonality. We empirically /ink that vision to the entrepreneurial psyche and use that to build insight into the entrepreneurial enigma, the process  of entrepreneurship

Evolution of Medical Students\u27 Understanding of Systems-Based Practice: A Qualitative Account

Reflective writing is a useful tool in medical education to analyze student experiences and measure development of certain skills. This tool is particularly useful in identifying skill components of systems-based practice. These skills are necessary for any practicing physician, but are of particular importance as they are a required residency competency. There is now additional focus on systems-based practice with the passage of the Patient Protection and Affordable Care Act (ACA). In this qualitative, grounded theory study, the reflective writings of students at a United States medical school were analyzed using the constant comparative method to explore how the focus of a medical student progresses through the clinical curriculum. The interprofessional team of researchers specifically sought to determine if areas of medical student focus evolve vertically across the curriculum and if in the process students develop an understanding of systems-based practice. The data supported both of these objectives, and actively supports future research to identify ways, both inside and outside the curriculum, to leverage the students’ natural progression of focus in order to expand systems-based practice education

Persistence of carry-over effects in the spotted salamander.

Most organisms have complex life cycles. Early conditions can constrain phenotype and influence growth and survival later in life. Linkages between life stages are important for conservation and management