Shop-floor bargaining and the struggle for job control in the British automobile and aerospace industries 1950-1982

In the UK automobile and aerospace industries, the struggle over job control and rewards for labour expended in the production process was particularly intense in the period of steady economic growth, high and stable employment, and low inflation, following the Second World War. This struggle reached its zenith during a phase of increasing output in the 1950s and early 1960s. By the late 1960s, however, as wages and unemployment began to rise and the rate of growth slowed there was a discernible shift in management industrial relations strategy and efforts by government to curb the authority and influence of shop-stewards. Despite disparities both between and within these respective industries, particularly the higher skill levels required by the aerospace sector, common experiences of the transformation of labour conditions of work are noticeable. In mapping some key historical struggles of automobile and aerospace workers against management forms of authority and control, it should be possible to distinguish the critical dynamics prevalent in both industries. Knowledge of the trajectory of labour relations and the pattern and character of conflict is critical to understanding and accounting for continuity and change in the social relations of production

Aristotle\u27s Theory of Genius Examined through Reid\u27s Theory of Natural Signs

This paper explains how we might comprehend Aristotle’s paradoxical theory of metaphor via Thomas Reid’s theory of natural signs. A realist, Aristotle believes that metaphor, as a stretching of the structure of language, relies on a fundamental relationship between things in the world. Metaphors are better or worse depending on the selection of fitting terms, and good metaphors are said to be the sign of genius. Metaphor mastery cannot be taught, but rather is an “intuitive perception”. Since what cannot be learned cannot be predicated on concepts, Reid’s account of the second type of natural signs helps clarify how Aristotle’s “similarity in dissimilars” is discoverable. Furthermore, that such natural signs do not depend on experience but rather are known to all given the “constitution of human nature,” explains away the problem of how a non-genius would be able to comprehend a metaphor without being able to create one

Under-dominance constrains the evolution of negative autoregulation in diploids

Regulatory networks have evolved to allow gene expression to rapidly track changes in the environment as well as to buffer perturbations and maintain cellular homeostasis in the absence of change. Theoretical work and empirical investigation in Escherichia coli have shown that negative autoregulation confers both rapid response times and reduced intrinsic noise, which is reflected in the fact that almost half of Escherichia coli transcription factors are negatively autoregulated. However, negative autoregulation is exceedingly rare amongst the transcription factors of Saccharomyces cerevisiae. This difference is all the more surprising because E. coli and S. cerevisiae otherwise have remarkably similar profiles of network motifs. In this study we first show that regulatory interactions amongst the transcription factors of Drosophila melanogaster and humans have a similar dearth of negative autoregulation to that seen in S. cerevisiae. We then present a model demonstrating that this fundamental difference in the noise reduction strategies used amongst species can be explained by constraints on the evolution of negative autoregulation in diploids. We show that regulatory interactions between pairs of homologous genes within the same cell can lead to under-dominance - mutations which result in stronger autoregulation, and decrease noise in homozygotes, paradoxically can cause increased noise in heterozygotes. This severely limits a diploid's ability to evolve negative autoregulation as a noise reduction mechanism. Our work offers a simple and general explanation for a previously unexplained difference between the regulatory architectures of E. coli and yeast, Drosophila and humans. It also demonstrates that the effects of diploidy in gene networks can have counter-intuitive consequences that may profoundly influence the course of evolution

Delusional Infestation:Perspectives from Scottish Dermatologists and a 10-year Case Series from a Single Centre

Perceptions of the clinical management of delusional infestation (DI) were compared with clinical outcomes in this 10-year case series from a single centre in Dundee, UK. An online questionnaire (survey-monkey, a TM brand of online survey available for free for basic use) was sent to Scottish Dermatologists to gauge their opinions and confidence in the management of DI. Also, a retrospective review of medical case notes of patients seen by dermatologists in one institution was undertaken and clinical outcomes were reported by patients’ general practitioners (GP). The survey showed that 61% of responding dermatologists encountered 1–5 cases of DI per year. Twenty-four percent respondees were ‘confident’ in managing patients with DI, 54% were ‘somewhat confident’. Forty-seven patients (62% female, 70% single) were seen over the 10 years; 43% brought a self-collected specimen to clinic, 68% of patients had a psychiatric comorbidity, 23% of patients had primary DI and 11/47 (23%) were seen by a psychiatrist. Clinical outcomes as rated by patients’ GPs were reasonable or good in 2/3 patients. A poor outcome was seen in 12 patients and associated with chronic pain in 50% (p< 0.01) and psychiatric comorbidity in 100% (p < 0.01). We conclude that good outcomes can be achieved in some patients with DI without psychiatric input and without psychoactive treatment

The application of inelastic neutron scattering to investigate the interaction of methyl propanoate with silica

A modern industrial route for the manufacture of methyl methacrylate involves the reaction of methyl propanoate and formaldehyde over a silica-supported Cs catalyst. Although the process has been successfully commercialised, little is known about the surface interactions responsible for the forward chemistry. This work concentrates upon the interaction of methyl propanoate over a representative silica. A combination of infrared spectroscopy, inelastic neutron scattering, DFT calculations, X-ray diffraction and temperature-programmed desorption is used to deduce how the ester interacts with the silica surface