A semi-implicit numerical method for treating the time transient gas lubrication equation

Numerical method for treating time transient gas lubrication equatio

Challenging the orthodoxy: union learning representatives as organic intellectuals

Teacher education and continuing professional development have become a key areas of controversy in England since the period of school sector restructuring following the 1988 Education Reform Act. More recently teacher training and professional development have often been used to promote and reinforce a narrow focus on the government’s ‘standards agenda’. However, the emerging discourse of ‘new professionalism’ has raised the profile of professional development in schools, and together with union learning representatives, there are opportunities to secure real improvements in teachers’ access to continuing professional development. This paper argues however that union learning representatives must go beyond advocating for better access to professional development and should raise more fundamental questions about the nature of professional development and the education system it serves. Drawing on Gramsci’s notion of the ‘organic intellectual’, the paper argues that union learning representatives have a key role as organisers of ideas – creating spaces in which the ideological dominance of current policy orthodoxy might be challenged

Active Carbon and Oxygen Shell Burning Hydrodynamics

We have simulated 2.5$\times10^3$ s of the late evolution of a $23 \rm M_\odot$ star with full hydrodynamic behavior. We present the first simulations of a multiple-shell burning epoch, including the concurrent evolution and interaction of an oxygen and carbon burning shell. In addition, we have evolved a 3D model of the oxygen burning shell to sufficiently long times (300 s) to begin to assess the adequacy of the 2D approximation. We summarize striking new results: (1) strong interactions occur between active carbon and oxygen burning shells, (2) hydrodynamic wave motions in nonconvective regions, generated at the convective-radiative boundaries, are energetically important in both 2D and 3D with important consequences for compositional mixing, and (3) a spectrum of mixed p- and g-modes are unambiguously identified with corresponding adiabatic waves in these computational domains. We find that 2D convective motions are exaggerated relative to 3D because of vortex instability in 3D. We discuss the implications for supernova progenitor evolution and symmetry breaking in core collapse.Comment: 5 pages, 4 figures in emulateapj format. Accepted for publication in ApJ Letters. High resolution figure version available at http://spinach.as.arizona.ed

Suggested Lines of Advance in English Vital Statistics

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Golabi-Ito-Hall syndrome results from a missense mutation in the WW domain of the PQBP1 gene

Background: Golabi, Ito, and Hall reported a family with X linked mental retardation (XLMR), microcephaly, postnatal growth deficiency, and other anomalies, including atrial septal defect, in 1984.Methods: This family was restudied as part of our ongoing study of XLMR, but significant linkage to X chromosome markers could not be found. Extreme short stature and microcephaly as well as other new clinical findings were observed. Mutations in the polyglutamine tract binding protein 1 gene (PQBP1) have recently been reported in four XLMR disorders (Renpenning, Hamel cerebro-palato-cardiac, Sutherland-Haan, and Porteous syndromes) as well as in several other families. The clinical similarity of our family to these patients with mutations in PQBP1, particularly the presence of microcephaly, short stature, and atrial septal defect, prompted examination of this gene.Results: A missense mutation in PQBP1 was identified which changed the conserved tyrosine residue in the WW domain at position 65 to a cysteine (p.Y65C).Conclusions: This is the first missense mutation identified in PQBP1 and the first mutation in the WW domain of the gene. The WW domain has been shown to play an important role in the regulation of transcription by interacting with the PPxY motif found in transcription factors. The p.Y65C mutation may affect the proper functioning of the PQBP1 protein as a transcriptional co-activator

Bryophytes of Uganda : 2., new and interesting records

51 hepatics and 46 mosses are reported new to Uganda, including one moss new to Africa, one hepatic and two mosses new to mainland Africa, and 2 hepatics that are otherwise known only from their type collection

Molecular orientational dynamics of the endohedral fullerene Sc3_{3}N@C80_{80} as probed by 13^{13}C and 45^{45}Sc NMR

We measure 13C and 45Sc NMR lineshapes and spin-lattice relaxation times (T1) to probe the orientational dynamics of the endohedral metallofullerene Sc3N@C80. The measurements show an activated behavior for molecular reorientations over the full temperature range with a similar behavior for the temperature dependence of the 13C and 45Sc data. Combined with spectral data from Magic Angle Spinning (MAS) NMR, the measurements can be interpreted to mean the motion of the encapsulated Sc3N molecule is independent of that of the C80 cage, although this requires the similar temperature dependence of the 13C and 45Sc spin-lattice relaxation times to be coincidental. For the Sc3N to be fixed to the C80 cage, one must overcome the symmetry breaking effect this has on the Sc3N@C80 system since this would result in more than the observed two 13C lines.Comment: 6 pages, 5 figure

The calpastatin-derived calpain inhibitor CP1B reduces mRNA expression of matrix metalloproteinase-2 and-9 and invasion by leukemic THP-1 cells

The ubiquitous proteases μ- and m-calpain are Ca2+-dependent cysteine endopeptidases. Besides involvement in a variety of physio(patho)logical processes, recent studies suggest a pivotal role of calpains in differentiation of hematopoietic cells and tumor cell invasion. However, the precise actions of calpains and their endogenous inhibitor, calpastatin, in these processes are only partially understood. Here we have studied the role of the calpain/calpastatin system in the invasion of leukemic cells under basal and differentiationstimulating conditions. To further differentiate the human leukaemic cell line THP-1 (monocytic), the cells were treated for 24 hours with the differentiationstimulating reagents phorbol 12-myristate 13-acetate (PMA) and dimethyl sulfoxide (DMSO). Macrophage and granulocytelike differentiation was confirmed by induction of vimentin expression as well as by microscopic and fluorescence assisted cytometric analysis. Extracellular matrix (ECM) invasion of both the basal and differentiation stimulated cells in a Matrigel assay was inhibited by preincubation of the cells with the specific calpain inhibitor CP1B for 24 hours. Inhibition of invasiveness correlated with decreased mRNA expression and secretion of the matrix metalloproteinases MMP-2 and MMP-9. In contrast, addition of CP1B only during the invasion process did neither influence transmigration nor MMP release. This is the first report showing that the calpain/calpastatin system mediates MMPmRNA expression of the leukemic THP-1 cells and as a consequence their invasiveness

Simulation studies of air transport operational problems

An experimental evaluation of the monitored approach procedure for conducting low visibility instrument approaches is described. Four airline crews each flew 16 approaches using the monitored procedure and 16 using a modified standard procedure in a DC-10 simulator under various conditions of visibility, wind shear and turbulence, and radar vectoring scenarios. In terms of system measures of aircrew performance, no major differences were found. Pilot opinion data indicate that there are some desirable characteristics of the monitored procedure, particularly with reference to the increased role of the flight engineer in conducting low visibility approaches. Rationale for developing approach procedures is discussed