Layout of Multiple Views for Volume Visualization: A User Study

Abstract. Volume visualizations can have drastically different appearances when viewed using a variety of transfer functions. A problem then occurs in trying to organize many different views on one screen. We conducted a user study of four layout techniques for these multiple views. We timed participants as they separated different aspects of volume data for both time-invariant and time-variant data using one of four different layout schemes. The layout technique had no impact on performance when used with time-invariant data. With time-variant data, however, the multiple view layouts all resulted in better times than did a single view interface. Surprisingly, different layout techniques for multiple views resulted in no noticeable difference in user performance. In this paper, we describe our study and present the results, which could be used in the design of future volume visualization software to improve the productivity of the scientists who use it

Human Swarm Interaction: An Experimental Study of Two Types of Interaction with Foraging Swarms

In this paper we present the first study of human-swarm interaction comparing two fundamental types of interaction, coined intermittent and environmental. These types are exemplified by two control methods, selection and beacon control, made available to a human operator to control a foraging swarm of robots. Selection and beacon control differ with respect to their temporal and spatial influence on the swarm and enable an operator to generate different strategies from the basic behaviors of the swarm. Selection control requires an active selection of groups of robots while beacon control exerts an influence on nearby robots within a set range. Both control methods are implemented in a testbed in which operators solve an information foraging problem by utilizing a set of swarm behaviors. The robotic swarm has only local communication and sensing capabilities. The number of robots in the swarm range from 50 to 200. Operator performance for each control method is compared in a series of missions in different environments with no obstacles up to cluttered and structured obstacles. In addition, performance is compared to simple and advanced autonomous swarms. Thirty-two participants were recruited for participation in the study. Autonomous swarm algorithms were tested in repeated simulations. Our results showed that selection control scales better to larger swarms and generally outperforms beacon control. Operators utilized different swarm behaviors with different frequency across control methods, suggesting an adaptation to different strategies induced by choice of control method. Simple autonomous swarms outperformed human operators in open environments, but operators adapted better to complex environments with obstacles. Human controlled swarms fell short of task-specific benchmarks under all conditions. Our results reinforce the importance of understanding and choosing appropriate types of human-swarm interaction when designing swarm systems, in addition to choosing appropriate swarm behaviors

The Moderating Effect of Organizational Social Phenomenon on the Psychological Well-Being of Military Peacekeepers

The University Archives has determined that this item is of continuing value to OSU's history.Session 3: Community, Organizations, Culture, and Foster Care. Presenter: Steve Juan Lewis, Ph.D., Florida State University (2003) - "The Moderating Effect of Organizational Social Phenomenon on the Psychological Well-Being of Military Peacekeepers"The Ohio State University College of Social Wor

Functional Analysis of Non-Genetic Resistance to Platinum in Epithelial Ovarian Cancer Reveals a Role for the MBD3-NuRD Complex in Resistance Development

Epithelial ovarian cancer (EOC) is the most lethal disease of the female reproductive tract, and although most patients respond to the initial treatment with platinum (cPt)-based compounds, relapse is very common. We investigated the role of epigenetic changes in cPt-sensitive and -resistant EOC cell lines and found distinct differences in their enhancer landscape. Clinical data revealed that two genes (JAK1 and FGF10), which gained large enhancer clusters in resistant EOC cell lines, could provide novel biomarkers for early patient stratification with statistical independence for JAK1. To modulate the enhancer remodeling process and prevent the acquisition of cPt resistance in EOC cells, we performed a chromatin-focused RNAi screen in the presence of cPt. We identified subunits of the Nucleosome Remodeling and Deacetylase (NuRD) complex as critical factors sensitizing the EOC cell line A2780 to platinum treatment. Suppression of the Methyl-CpG Binding Domain Protein 3 (MBD3) sensitized cells and prevented the establishment of resistance under prolonged cPt exposure through alterations of H3K27ac at enhancer regions, which are differentially regulated in cPt-resistant cells, leading to a less aggressive phenotype. Our work establishes JAK1 as an independent prognostic marker and the NuRD complex as a potential target for combinational therapy

Effect of Heat on Canines and Felines

Exposure of dogs and cats to high environmental temperatures may have serious and often fatal consequences. This article will briefly discuss the harmful effects of heat, known as heat stress (heat strokes, hyperpyrexia, sun stroke), which is characterized by acute onset, high body temperature, and collapse

A diagnosis of low-order dynamics in the atmosphere of Mars

Introduction: There is considerable evidence that shows that the Martian atmosphere behaves in a more regular fashion than its terrestrial counterpart [1, 2, 3, 4]. This evidence leads to the hypothesis of theMartian climate attractor being of a relatively low dimension, which, in turn, would imply the possibility of describing the state of the atmosphere by means of a relatively few degrees of freedom. We explore this hypothesis by assuming that the atmospheric total energy (TE), i.e. the sum of kinetic energy and total potential energy (gravitational potential energy plus internal energy), is confined in a few coherent structures which dynamically interact nonlinearly with each other

DNA Methylation Analysis Validates Organoids as a Viable Model for Studying Human Intestinal Aging.

Background & aimsThe epithelia of the intestine and colon turn over rapidly and are maintained by adult stem cells at the base of crypts. Although the small intestine and colon have distinct, well-characterized physiological functions, it remains unclear if there are fundamental regional differences in stem cell behavior or region-dependent degenerative changes during aging. Mesenchyme-free organoids provide useful tools for investigating intestinal stem cell biology in vitro and have started to be used for investigating age-related changes in stem cell function. However, it is unknown whether organoids maintain hallmarks of age in the absence of an aging niche. We tested whether stem cell-enriched organoids preserved the DNA methylation-based aging profiles associated with the tissues and crypts from which they were derived.MethodsTo address this, we used standard human methylation arrays and the human epigenetic clock as a biomarker of age to analyze in vitro-derived, 3-dimensional, stem cell-enriched intestinal organoids.ResultsWe found that human stem cell-enriched organoids maintained segmental differences in methylation patterns and that age, as measured by the epigenetic clock, also was maintained in vitro. Surprisingly, we found that stem cell-enriched organoids derived from the small intestine showed striking epigenetic age reduction relative to organoids derived from colon.ConclusionsOur data validate the use of organoids as a model for studying human intestinal aging and introduce methods that can be used when modeling aging or age-onset diseases in vitro

Profitability and risk evaluation of novel perennial pasture systems for livestock producers in the high rainfall zone: Context, Approach and Preliminary Results

The decision to invest in pasture improvement raises various questions for the livestock grazier, with the most pertinent being about the potential returns and risks. In the high rainfall zone of south-west Victoria, researchers have trialled novel perennial pasture systems with the aim of substantially increasing on-farm profits whilst simultaneously improving environmental outcomes. Results from the Hamilton EverGraze® proof site have shown potential to greatly improve livestock production. Promotion of the pasture technology is the next step. Key to this process is developing information about profitability and risk regarding the decision to invest in the new pasture. To help meet this need a model of a representative mixed livestock farm system for the region has been developed to generate information about profit, cash wealth and risk to aid extension and help inform decisions. The farm is comprised of a wool and meat producing sheep system and a beef enterprise. Using the model, the performance of two of the novel pasture systems can be evaluated against current practice, and compared to determine which of the two is the most beneficial EverGraze® option for the future. The risk associated with the pasture decision is assessed by considering different price structures and seasonal outcomes, and evaluating these effects on net benefits. Discounted cash flows, net present values and internal rates of return are estimated for the alternative systems, which include the effects of this price and seasonal variability. Preliminary results have been calculated, however further work is needed to confirm these. The method and results of the analysis provide information that is valuable for farm decisions about investing in a new pasture system and provide a basis for future economic analyses at the case study site and elsewhere.Farm Management,