Exile Vol. XLIX

47th Year Title Page 3 Epigraph by Ezra Pound 5 Table of Contents 7 Contributors\u27 Notes 62-63 Editorial Board 64 ART Hidden by Elizabeth Averbeck \u2704 8 Untitled by Laura Cannon \u2705 10 Untitled by Matt Messmer \u2706 16 Hierve el agua by Emily stenken \u2703 18 A Late One by Sarah R. Smith \u2703 27 Between the Lines by Gregory Holden \u2703 30 Carwash by Gregory Holden \u2703 40 Untitled by Laura Cannon \u2705 42 Flowers in Her Hair by Gregory Holden \u2703 53 Untitled Forrest by Jessica Kramer \u2703 56 POETRY What the Dead Had Grown by Steve Kovach \u2703 9 European Affairs by Ginna Fuselier \u2703 17 Combing the Everglades by Scott Barsotti \u2703 28-29 Persecution by Steve Kovach \u2703 41 A few coins in a styrofoam cup by Miranda Bodfish \u2705 54-55 FICTION Here\u27s to Mary by Katie Mannel \u2705 11-15 The Game of Right by Bradley Prefling \u2703 19-26 The Interview by Nicole Bennett \u2704 31-39 Jet Black Chevrolet by Scott Barsotti \u2703 43-52 Fulfilling Duty by Daniel Kinicki \u2705 57-61 All submissions are reviewed on an anonymous basis, and all editorial decisions are shared equally among the members of the Editorial Board. -64 Cover Art Despair by Gregory Holden \u2703 / Back Cover Art Untitled by Laura Cannon \u2705 -64 Printing by Printing Arts Press -64 Scott Barsotti, Jet Black Chevrolet redacted due to copyright restrictions

A Simulation Model Examining Boll Weevil Dispersal: Historical and Current Situations

A linear deterministic simulation model was developed to examine the historical rate of movement of the boll weevil, Anthonomus grandis grandis Boheman, across the southeastern United States. This manuscript addresses the hypotheses proposed during the initial invasion of the boll weevil that cotton production and prevailing winds were the primary factors regulating movement of this pest. A modification of the historical model was used to predict defensive strategies required to maintain boll weevil-free areas resulting from the current program effort

Moyo Vol. X N 2

Million, Chris. Editor\u27s Letter . 4. Kaczur, Erin. Why It Sucks to be Human: I Would Like to Change My Casing, Not My Underwear . 5. Dunson, Jim and Tom Hankinson. MoYummy: Our Staff Connoisseurs Hit the Spots That Hit the Spot . 6. Fisher, Dan. Happy, O Monk, Is Thy Shadow! A No Pluses, No Minuses Memory of a Spiritual Friend . 10. Reuss, Liz. Who is S/He? Leslie Feinberg Interview Inspires Introspection . 11. Marston, Jennifer. MoYo Millenium Picks: Ghandi Can Forget it . 12. Bungard, Chris. Pop The Cork on Ireland. Strictly No Drinking Stritly Ignored . 13. Wilson, Kalyn. Pagans in print: The Craft--So Much more Than Sabrina . 14. Mallinger, Adam. DU Press Release Revisited . 16. Zellner, Kelli. Denison University\u27s Campus Compact--Myth or Reality? DU\u27s Bubble, Burst . 17. Hankinson, Tom. Bureaucracy--Friend of the Common man. An Explication Rather Than an Expletive . 18. The TasyPaycheck. A Very Tasty Quiz: The Denison Social Hierarchy - Do You Cut it? 20. Mong, Derek. The Armpit Epiphany . 21. Curry, Kim. Hot Child in The City: An Unaccustomed look Back from a Big Apple Intern . 22. Million, Chris. Their Last Chance! 32. Kovach, Steve. Risk-y Business: Strategies for Getting More enjoyment Out of World Conquest . 34

Analysis of Cancer Mutation Signatures in Blood by a Novel Ultra-Sensitive Assay: Monitoring of Therapy or Recurrence in Non-Metastatic Breast Cancer

BACKGROUND: Tumor DNA has been shown to be present both in circulating tumor cells in blood and as fragments in the plasma of metastatic cancer patients. The identification of ultra-rare tumor-specific mutations in blood would be the ultimate marker to measure efficacy of cancer therapy and/or early recurrence. Herein we present a method for detecting microinsertions/deletions/indels (MIDIs) at ultra-high analytical selectivity. MIDIs comprise about 15% of mutations. METHODS AND FINDINGS: We describe MIDI-Activated Pyrophosphorolysis (MAP), a method of ultra-high analytical selectivity for detecting MIDIs. The high analytical selectivity of MAP is putatively due to serial coupling of two rare events: heteroduplex slippage and mis-pyrophosphorolysis. MAP generally has an analytical selectivity of one mutant molecule per >1 billion wild type molecules and an analytical sensitivity of one mutant molecule per reaction. The analytical selectivity of MAP is about 100,000-fold better than that of our previously described method of Pyrophosphorolysis Activated Polymerization-Allele specific amplification (PAP-A) for detecting MIDIs. The utility of this method is illustrated in two ways. 1) We demonstrate that two EGFR deletions commonly found in lung cancers are not present in tissue from four normal human lungs (10(7) copies of gDNA each) or in blood samples from 10 healthy individuals (10(7) copies of gDNA each). This is inconsistent, at least at an analytical sensitivity of 10(-7), with the hypotheses of (a) hypermutation or (b) strong selection of these growth factor-mutated cells during normal lung development leads to accumulation of pre-neoplastic cells with these EGFR mutations, which sometimes can lead to lung cancer in late adulthood. Moreover, MAP was used for large scale, high throughput "gene pool" analysis. No germline or early embryonic somatic mosaic mutation was detected (at a frequency of >0.3%) for the 15/18 bp EGFR deletion mutations in 6,400 individuals, suggesting that early embryonic EGFR somatic mutation is very rare, inconsistent with hypermutation or strong selection of these deletions in the embryo. 2) The second illustration of MAP utility is in personalized monitoring of therapy and early recurrence in cancer. Tumor-specific p53 mutations identified at diagnosis in the plasma of six patients with stage II and III breast cancer were undetectable after therapy in four women, consistent with clinical remission, and continued to be detected after treatment in two others, reflecting tumor progression. CONCLUSIONS: MAP has an analytical selectivity of one part per billion for detection of MIDIs and an analytical sensitivity of one molecule. MAP provides a general tool for monitoring ultra-rare mutations in tissues and blood. As an example, we show that the personalized cancer signature in six out of six patients with non-metastatic breast cancer can be detected and that levels over time are correlated with the clinical course of disease

Implications of machine-learning, internet-tests to save lives and money: 7-point violence profile: review of 212 studies, 320,051 persons, over 95 years, with a cross-validation among 136 homicidal, overdosing- substance-abusing, sex-offending

Analysis of 136 persons with psychopathology, suicidal ideation, and violence included: (a) 79 adults [12 homicidal, 13 overdosing-substance-abusers, 15 sex-offending, 15 suicide-completers, 24 controls (23 women, 56 men) Mage=38.29]; and (b) 57 teens [11 homicidal, 7 overdosing-substance-abusers, 10 sex-offending, 17 suicide-completers, 12 controls (15 girls, 42 boys) Mage= 15.37] given (Standard Predictor of Violence Potential (SP), Quick Test (QT), Beck Scale (BSS), MMPI-2/A, Raven Matrices). Significant (p \u3c .05) ANOVA Fs were: (a) adults (SP, BSS, MMPI-2 [VRIN, F, FB, FP, L, K, S, Hs (1), D (2), Pd (4), Mf (5), Pa(6), Pt(7), Sc (8), Ma (9), Si (10), MAC-R, APS, AAS], Raven; and (b) teens (SP, BSS, MMPI-A [F1, F, L, K, D (2), Pa (6), Sc (8)], QT. At-risk, adults, and teens had the same “7-point violence profile” (SP -, “F/L-2-4-6-8-AAS(ACK)”) [insignificant differences (p \u3c .05) ANOVA-Fs: SP, BSS, MMPI-2/A: F, L, K, D (2), Pd (4), Pa (6), Sc (8)]