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Fostering Insight and Collaboration in Long-Term Healthcare through Collection and Visualization of Qualitative Healthcare Data

The Care and Condition Monitor (CCM) is a tablet-based, networked visual analytics tool for collecting, structuring and analyzing informal and qualitative healthcare data. Building off research into application usability and best practices for communicating complex information, CCM illustrates how visual analytics tools coupled with social communication within teams of caregivers enables capturing of longitudinal informal data that would otherwise go unrecorded. This expanded scope of information can support medical decision making by making it possible to analyze informal and qualitative health care data,creating a multi-dimensional holistic picture of a person‟s health care and condition over time

PPARG SIGNALING IN THE NUCLEUS ACCUMBENS REGULATES MESOLIMBIC DOPAMINE ACTIVITY

Background: The mesolimbic dopamine system consists of dopamine neuron projections from the ventral tegmental area (VTA) to the nucleus accumbens (NAc). The NAc regulates VTA dopamine release through inhibitory GABA projections to the VTA. Hyperactive mesolimbic dopamine signaling is implicated in anxiety. Cannabidiol, a compound found in cannabis, demonstrates promising therapeutic potential for anxiety through the regulation of the mesolimbic dopamine system. Previous studies have revealed that cannabidiol infusions into the NAc decreases mesolimbic dopamine activity - potentially through the inhibitory GABA signaling to the VTA. However, the receptor mechanism in the NAc through which CBD produces its effects is unknown. Peroxisome proliferator-activated receptor gamma (PPARG) is a nuclear transcription factor that binds to CBD and colocalizes with GABA neurons. Recent evidence suggests that PPARG activation can decrease mesolimbic dopamine activity through inhibitory GABA signaling. Considering that the NAc expresses high levels of PPARG, intra-NAc CBD may regulate mesolimbic dopamine activity through PPARG activation. Hypothesis: PPARG activation in the NAc regulates mesolimbic dopamine transmission through the modulation of the GABAergic inhibition of the VTA. Methods: In-vivo electrophysiology was used to investigate the effects of intra-NAc PPARG activation on mesolimbic dopamine activity. The anxiolytic effects of intra-NAc PPARG activation was measured using the light-dark box and elevated plus maze behavioural tests. Results: We report that PPARG activation in the NAc significantly decreases mesolimbic dopamine activity whereas PPARG antagonists block this effect. Additionally, we reveal that intra-NAc PPARG activation produces anxiolytic effects as measured in the light-dark box and elevated plus maze behavioural tests

General Interviewing Techniques: Developing Evidence-Based Practices

This poster is a hands-on demonstration of the in-progress General Interviewer Techniques (GIT) materials described by Schaeffer, Dykema, Coombs, Schultz, Holland, and Hudson. Participants will be able to view and listen to the lesson materials, delivered via an online interface, and talk to the GIT developers