A systematic review of how homeopathy is represented in conventional and CAM peer reviewed journals

BACKGROUND: Growing popularity of complementary and alternative medicine (CAM) in the public sector is reflected in the scientific community by an increased number of research articles assessing its therapeutic effects. Some suggest that publication biases occur in mainstream medicine, and may also occur in CAM. Homeopathy is one of the most widespread and most controversial forms of CAM. The purpose of this study was to compare the representation of homeopathic clinical trials published in traditional science and CAM journals. METHODS: Literature searches were performed using Medline (PubMed), AMED and Embase computer databases. Search terms included "homeo-pathy, -path, and -pathic" and "clinical" and "trial". All articles published in English over the past 10 years were included. Our search yielded 251 articles overall, of which 46 systematically examined the efficacy of homeopathic treatment. We categorized the overall results of each paper as having either "positive" or "negative" outcomes depending upon the reported effects of homeopathy. We also examined and compared 15 meta-analyses and review articles on homeopathy to ensure our collection of clinical trials was reasonably comprehensive. These articles were found by inserting the term "review" instead of "clinical" and "trial". RESULTS: Forty-six peer-reviewed articles published in a total of 23 different journals were compared (26 in CAM journals and 20 in conventional journals). Of those in conventional journals, 69% reported negative findings compared to only 30% in CAM journals. Very few articles were found to be presented in a "negative" tone, and most were presented using "neutral" or unbiased language. CONCLUSION: A considerable difference exists between the number of clinical trials showing positive results published in CAM journals compared with traditional journals. We found only 30% of those articles published in CAM journals presented negative findings, whereas over twice that amount were published in traditional journals. These results suggest a publication bias against homeopathy exists in mainstream journals. Conversely, the same type of publication bias does not appear to exist between review and meta-analysis articles published in the two types of journals

Identifying novel phenotypes of elevated left ventricular end diastolic pressure using hierarchical clustering of features derived from electromechanical waveform data

Introduction Elevated left ventricular end diastolic pressure (LVEDP) is a consequence of compromised left ventricular compliance and an important measure of myocardial dysfunction. An algorithm was developed to predict elevated LVEDP utilizing electro-mechanical (EM) waveform features. We examined the hierarchical clustering of selected features developed from these EM waveforms in order to identify important patient subgroups and assess their possible prognostic significance. Materials and methods Patients presenting with cardiovascular symptoms (N = 396) underwent EM data collection and direct LVEDP measurement by left heart catheterization. LVEDP was classified as non-elevated ( ≤ 12 mmHg) or elevated (≥25 mmHg). The 30 most contributive features to the algorithm output were extracted from EM data and input to an unsupervised hierarchical clustering algorithm. The resultant dendrogram was divided into five clusters, and patient metadata overlaid. Results The cluster with highest LVEDP (cluster 1) was most dissimilar from the lowest LVEDP cluster (cluster 5) in both clustering and with respect to clinical characteristics. In contrast to the cluster demonstrating the highest percentage of elevated LVEDP patients, the lowest was predominantly non-elevated LVEDP, younger, lower BMI, and males with a higher rate of significant coronary artery disease (CAD). The next adjacent cluster (cluster 2) to that of the highest LVEDP (cluster 1) had the second lowest LVEDP of all clusters. Cluster 2 differed from Cluster 1 primarily based on features extracted from the electrical data, and those that quantified predictability and variability of the signal. There was a low predictability and high variability in the highest LVEDP cluster 1, and the opposite in adjacent cluster 2. Conclusion This analysis identified subgroups of patients with varying degrees of LVEDP elevation based on waveform features. An approach to stratify movement between clusters and possible progression of myocardial dysfunction may include changes in features that differentiate clusters; specifically, reductions in electrical signal predictability and increases in variability. Identification of phenotypes of myocardial dysfunction evidenced by elevated LVEDP and knowledge of factors promoting transition to clusters with higher levels of left ventricular filling pressures could permit early risk stratification and improve patient selection for novel therapeutic interventions

Efeito de várias disponibilidades hídricas, atuando como pré-condicionamento fisiológico durante a germinação das sementes de milho, no desenvolvimento das plântulas

The present paper considers the possible effects of physiological pre-treatment during the beginning of corn seeds germination in environments variable as to water availability (0 to -12 atm ). Periods of defficiency followed by 5 days without hydric limitations were compared with a control that remained equally, without reservations as to the disposability of water during 5 days. Results indicated that hydric pre-treatment of seeds can, if property adapted in its details, provide some advantages in the development of the seedlings derived from them. Chemical fungicide treatment of the seeds, submmited to the hydric pre-treatment may not be beneficial to the seedlings; as indicated by, in some isolated cases, the production of abnormalities in the embryonic structures.O presente trabalho buscou estimar os eventuais efeitos de pré-condicionamento fisiológico promovidos, durante o início da germinação das sementes de milho, por ambientes variáveis quanto à disponibilidade de água (0 a -12 atm). Para tanto, os períodos de deficiência eram sucedidos por prazos fixos de 5 dias sem limitações hídricas e comparados com uma testemunha que permaneceu, igualmente, sem restrições quanto à disponibilidade de água durante 5 dias. Os resultados encontrados indicaram que a técnica de pré-condicionamento hídrico das sementes pode, se devidamente adaptada em seus detalhes, propiciar algumas vantagens no desenvolvimento das plântulas delas oriundas. Adicionalmente, o tratamento químico fungicida das sementes, submetidas a pré-condicionamento hídrico, pode não trazer os benefícios esperados às plântulas; há casos isolados, ligados a produção de anormalidades nas estruturas embrionárias, em que o seu efeito é prejudicial

Preliminary response of Sandhills prairie to fire and bison grazing

This research determined the preliminary response of sandhills prairie to spring and summer prescribed burns, and their interaction with bison (Bison bison) grazing. Changes in species composition and standing crop were determined for paired (caged/uncaged) plots established in burned and unburned areas during the 1991 and 1992 growing seasons. End of season standing crop of both rhizomatous grasses and bunchgrasses was increased by spring burning on sands range sites. Summer burning did not affect rhizomatous grass standing crop, but dramatically reduced bunchgrass standing crop. On burned areas, bison grazing reduced bunchgrass standing crop by 56%, while reducing rhizomatous grass standing crop by only 18%. Forbs generally appeared unaffected by bison grazing and were affected variously by burning. The current bunchgrass composition of Nebraska Sandhills prairie appears dependent on fire exclusion. With fire, a replacement of bunchgrass with rhizomatous grasses may increase available forage, but also increase the risk of wind erosion, particularly on choppy sands range sites.The Journal of Range Management archives are made available by the Society for Range Management and the University of Arizona Libraries. Contact [email protected] for further information.Migrated from OJS platform August 202

Bison use of fire-managed remnant prairies

This study was designed to: 1) compare the landscape distribution patterns of bison on fire-managed prairie remnants in the tallgrass (Oklahoma), and mixed prairie (Nebraska); and 2) identify the extent to which fire and range site [topoedaphic classification of the landscape] affect bison distribution patterns. This research was conducted at 2 sites: the Niobrara Valley Preserve (1990–1996), and the Tallgrass Prairie Preserve (1993–1996). At both preserves, bison selected burned areas during the growing season for 1–3 years and mostly avoided old burns and unburned areas. There was an interaction between fire and range site in selection patterns. In the absence of fire, bison mostly avoided both the Choppy Sandrange sites at the Niobrara Valley Preserve and Loamy Prairie range sites at the Tallgrass Prairie Preserve. When they were burned, however, these sites were highly selected. The main difference in bison selection patterns between the Tallgrass Prairie Preserve and the Niobrara Valley Preserve was observed during the dormant season. In the Tallgrass Prairie Preserve, burned sites continue to be preferred during the dormant period for an average of 2 years while in the Niobrara Valley Preserve selections were random. These differences can be explained by 2 mechanisms: the fall and winter re-growth of forage at the more southern latitude and the significant physiognomic changes that fire can cause in tallgrass prairies. Our study documents a continuing interaction between the ecological processes of the fire regime and bison distribution and abundance within 2 of the major prairie landscapes of the Great Plains, and provides critical details for understanding this relationship.The Journal of Range Management archives are made available by the Society for Range Management and the University of Arizona Libraries. Contact [email protected] for further information.Migrated from OJS platform August 202

Seedbank characteristics of a Nebraska sandhills prairie

Evaluating seedbank ecology is critical for understanding plant community development and successional patterns and for identifying factors regulating population dynamics. The relationships among seedbank composition, seedbank depth, seed dormancy, and vegetative expression were evaluated for a range site on a Valentine fine sand soil (mixed, mesic Typic Ustipsamments) in the Sandhills Prairie. Twenty soil samples were collected at each of 2 depths (0 to 5, 15 to 20 cm) in early June 1990 and 1991 from 12 macroplots (32 X 32 m) representing 3 range condition classes. A seed extraction and germination trial was conducted to determine the diversity, size, and germinability of the persistent seedbank. Seedling emergence was counted in a greenhouse, with and without a 14-day prechilling (3 to 5 degrees C) stratification treatment, to characterize seedbank dormancy. Fourteen grass species, 17 forb species, and Schweinitz flatsedge (Cyperus schweinitzii Torr.) were identified in the seed bank. Two additional genera (Carex and Euphorbia) also occurred in the seedbank. Only 10 species occurred in 8 or more macroplots in both years. Aboveground botanical composition was not correlated with (P > 0.10) seedbank species composition. More germinable seeds occurred in the 0 to 5 cm depth (P < 0.01) than the 15 to 20 cm depth. Also, the species diversity and seed number were greater in the shallower depth. Germination percentage was low for all types of vegetation. Lambsquarters (Chenopodium album L.) and annual eriogonum (Eriogonum annuum Nutt.) had the largest seedbanks, but germination was less than 6%. Sand dropseed [Sporobolus cryptandrus (Torr.) Gray] and sand lovegrass [Eragrostis trichodes (Nutt.) Wood] were the most abundant perennial grasses and accounted for about 60% of the germinated seeds. Prechilling increased seedling emergence of grasses (P < 0.01), forbs (P < 0.01), and grass-like species (P < 0.01). Perennial grasses emerged first, forbs later, and grasslike species exhibited a bimodal emergence pattern. Based on germination percentage and emergence data, sand dropseed has the potential to colonize openings in the Sandhills prairie, possibly to the exclusion of many annuals occurring in the seedbank.The Journal of Range Management archives are made available by the Society for Range Management and the University of Arizona Libraries. Contact [email protected] for further information.Migrated from OJS platform August 202