4,5-Epoxide-1,6-dimethyl-1-vinylhexyl p-coumarate: A novel monoterpene derivative from Cleistopholis patens

A novel monoterpene derivative (1) and four known partially and total acetylated tri- and tetrarhamonoside dodecanyl ether derivatives: cleistrioside-2 (2) and cleistrioside-3 (3), cleistetroside-6 (4) and cleistetroside peracetate (5) have been isolated from the fruits of Cleistopholis patens. KEY WORDS: Cleistopholis patens, Annonaceae, Oligosaccharide, Partially acetylated tri- and tetrarhamnoside dodecanyl ether derivatives, Cleistrioside, Cleistetroside, Monoterpene derivative  Bull. Chem. Soc. Ethiop. 2003, 17(2), 177-180

Gait speed as predictor of transition into cognitive impairment: Findings from three longitudinal studies on aging

Objectives: Very few studies looking at slow gait speed as early marker of cognitive decline investigated the competing risk of death. The current study examines associations between slow gait speed and transitions between cognitive states and death in later life. Methods: We performed a coordinated analysis of three longitudinal studies with 9 to 25 years of follow-up. Data were used from older adults participating in H70 (Sweden; n = 441; aged ≥70 years), InCHIANTI (Italy; n = 955; aged ≥65 years), and LASA (the Netherlands; n = 2824; aged ≥55 years). Cognitive states were distinguished using the Mini-Mental State Examination. Slow gait speed was defined as the lowest sex-specific quintile at baseline. Multistate models were performed, adjusted for age, sex and education. Results: Most effect estimates pointed in the same direction, with slow gait speed predicting forward transitions. In two cohort studies, slow gait speed predicted transitioning from mild to severe cognitive impairment (InCHIANTI: HR = 2.08, 95%CI = 1.40–3.07; LASA: HR = 1.33, 95%CI = 1.01–1.75) and transitioning from a cognitively healthy state to death (H70: HR = 3.30, 95%CI = 1.74–6.28; LASA: HR = 1.70, 95%CI = 1.30–2.21). Conclusions: Screening for slow gait speed may be useful for identifying older adults at risk of adverse outcomes such as cognitive decline and death. However, once in the stage of more advanced cognitive impairment, slow gait speed does not seem to predict transitioning to death anymore

Phase Behavior of Aqueous Na-K-Mg-Ca-CI-NO3 Mixtures: Isopiestic Measurements and Thermodynamic Modeling

A comprehensive model has been established for calculating thermodynamic properties of multicomponent aqueous systems containing the Na{sup +}, K{sup +}, Mg{sup 2+}, Ca{sup 2+}, Cl{sup -}, and NO{sub 3}{sup -} ions. The thermodynamic framework is based on a previously developed model for mixed-solvent electrolyte solutions. The framework has been designed to reproduce the properties of salt solutions at temperatures ranging from the freezing point to 300 C and concentrations ranging from infinite dilution to the fused salt limit. The model has been parameterized using a combination of an extensive literature database and new isopiestic measurements for thirteen salt mixtures at 140 C. The measurements have been performed using Oak Ridge National Laboratory's (ORNL) previously designed gravimetric isopiestic apparatus, which makes it possible to detect solid phase precipitation. Water activities are reported for mixtures with a fixed ratio of salts as a function of the total apparent salt mole fraction. The isopiestic measurements reported here simultaneously reflect two fundamental properties of the system, i.e., the activity of water as a function of solution concentration and the occurrence of solid-liquid transitions. The thermodynamic model accurately reproduces the new isopiestic data as well as literature data for binary, ternary and higher-order subsystems. Because of its high accuracy in calculating vapor-liquid and solid-liquid equilibria, the model is suitable for studying deliquescence behavior of multicomponent salt systems

<b>4,5-Epoxide-1,6-dimethyl-1-vinylhexyl <i>p</i>-coumarate: A novel monoterpene derivative from <i>Cleistopholis patens</i></b>

A novel monoterpene derivative (<b>1</b>) and four known partially and total acetylated tri- and tetrarhamonoside dodecanyl ether derivatives: cleistrioside-2 (<b>2</b>) and cleistrioside-3 (<b>3</b>), cleistetroside-6 (<b>4</b>) and cleistetroside peracetate (<b>5</b>) have been isolated from the fruits of <i>Cleistopholis patens</i>

4,5-Epoxide-1,6-dimethyl-1-vinylhexyl p-coumarate: A novel monoterpene derivative from Cleistopholis patens

A novel monoterpene derivative (1) and four known partially and total acetylated tri- and tetrarhamonoside dodecanyl ether derivatives: cleistrioside-2 (2) and cleistrioside-3 (3), cleistetroside-6 (4) and cleistetroside peracetate (5) have been isolated from the fruits of Cleistopholis patens