The Gene Ontology: enhancements for 2011

The Gene Ontology (GO) (http://www.geneontology.org) is a community bioinformatics resource that represents gene product function through the use of structured, controlled vocabularies. The number of GO annotations of gene products has increased due to curation efforts among GO Consortium (GOC) groups, including focused literature-based annotation and ortholog-based functional inference. The GO ontologies continue to expand and improve as a result of targeted ontology development, including the introduction of computable logical definitions and development of new tools for the streamlined addition of terms to the ontology. The GOC continues to support its user community through the use of e-mail lists, social media and web-based resources

Near-Infrared Microlensing of Stars by the Super-Massive Black Hole in the Galactic Center

We investigate microlensing amplification of faint stars in the dense stellar cluster in the Galactic Center (GC) by the super-massive black hole (BH). Such events would appear very close to the position of the radio source SgrA*, which is thought to coincide with the BH, and could be observed during the monitoring of stellar motions in the GC. We use the observed K-band (2.2 um) luminosity function (KLF) in the GC and in Baade's Window, as well as stellar population synthesis computations, to construct KLF models for the inner 300 pc of the Galaxy. These, and the observed dynamical properties of this region, are used to compute the rates of microlensing events, which amplify stars above specified detection thresholds. We present computations of the lensing rates and amplifications as functions of the event durations (weeks to years), for a range of detection thresholds. We find that short events dominate the total rate and that long events tend to have large amplifications. For the current detection limit of K=17 mag, the total microlensing rate is 0.003 1/yr, and the rate of events with durations >1 yr is 0.001 1/yr. Recent GC proper motion studies have revealed the possible presence of one or two variable K-band sources very close to SgrA* (Genzel et al 97; Ghez et al 98). These sources may have attained peak brightnesses of K~15 mag, about 1.5-2 mag above the observational detection limits, and appear to have varied on a timescale of ~1 yr. This behavior is consistent with long-duration microlensing of faint stars by the BH. However, we estimate that the probability that such an event could have been detected during the course of the recent proper motion studies is \~0.5%. A ten-fold improvement in the detection limit and 10 yr of monthly monitoring would increase the total detection probability to ~20%. (Abridged)Comment: 29 p. with 5 figs. To appear in ApJ. Changed to reflect published version. Short discussions of solar metallicity luminosity function and star-star microlensing adde

Leadership: Past, present, and future

In this introductory chapter, the editors of the present volume provide readers with the background necessary to understand the chapters that follow. They first acquaint readers with the concept of leadership and why leadership is necessary. Then, the editors briefly trace the history of leadership research and examine its major schools, most of which are reviewed in this book. Their historical overview is also necessary as an organizing framework because chapter authors frequently refer to elements of the history of leadership research. Next, the editors discuss emerging issues in leadership research and how findings are being consolidated. Finally, they provide an overview of the book and a summary of each chapter

Herd It in the Gobi: Deserting pastoralism?

Global drylands host more than USD 1 trillion in resource extraction investments, which serve to reconfigure communities and landscapes. In Mongolia’s Gobi Desert mega-mining brings social challenges and environmental changes that question if nomadic herding and mining can coexist. Whilst company and community conflict are common, nascent frameworks and mediation models suggest alternate ways to resolve the mining–community conundrum. Here we investigate environmental transformations that herders encounter in the presence of the Oyu Tolgoi mega-mine in Mongolia’s Khanbogd soum (district). Using socio-economic and physical data collected through interviews, field studies and climate records, we assessed local engagement and adaptation to largescale mining. Combining qualitative and quantitative methods enabled us to examine the implications of mining for herder lives and lands in an integrated way. This study presents a holistic assessment of the roles of herders, governments and mines in reshaping pastoralism. In our chosen case study, we find that—contrary to common narratives—mining and herding can, and do, coexist in Khanbogd soum, though ongoing challenges exist which deserve critical attention.info:eu-repo/semantics/publishedVersio

The no-core shell model with general radial bases

Calculations in the ab initio no-core shell model (NCSM) have conventionally been carried out using the harmonic-oscillator many-body basis. However, the rapid falloff (Gaussian asymptotics) of the oscillator functions at large radius makes them poorly suited for the description of the asymptotic properties of the nuclear wavefunction. We establish the foundations for carrying out no-core configuration interaction (NCCI) calculations using a basis built from general radial functions and discuss some of the considerations which enter into using such a basis. In particular, we consider the Coulomb-Sturmian basis, which provides a complete set of functions with a realistic (exponential) radial falloff.Comment: 7 pages, 3 figures; presented at Horizons on Innovative Theories, Experiments, and Supercomputing in Nuclear Physics 2012, New Orleans, Louisiana, June 4-7, 2012; submitted to J. Phys. Conf. Se

Experienced tutors' deployment of thinking skills and what might be entailed in enhancing such skills

In the context of research that reports weaknesses in adults' critical thinking skills, the primary aim was to examine adults' use of critical thinking skills that are described in taxonomies and to identify areas for development. Position papers written by an opportunity sample of 32 experienced adult educators formed the data for a descriptive sample survey design intended to reveal participants' use of critical thinking skills. Each 6000-word paper was written during a development programme that supported such skills. A content analysis of the papers revealed that when participants drew on personal and published ideas about learning to derive their proposals for change, they accepted the ideas uncritically, thereby implying that they might find it difficult to help learners to examine ideas critically. The evidence supports research that implies that critical thinking skills are unlikely to develop unless overall course design privileges the development of epistemological understanding (King and Kitchener 1994, Kuhn 1999). A fundamental assumption underlying the study is that this understanding influences effective citizenship and personal development, as well as employability. A proposition that merits attention in future research is that the development of epistemological understanding is largely neglected in current curricula in formal post-16 education

Origin and Evolution of Dishevelled

Dishevelled (Dsh or Dvl) is an important signaling protein, playing a key role in Wnt signaling and relaying cellular information for several developmental pathways. Dsh is highly conserved among metazoans and has expanded into a multigene family in most bilaterian lineages, including vertebrates, planarians, and nematodes. These orthologs, where explored, are known to have considerable overlap in function, but evidence for functional specialization continues to mount. We performed a comparative analysis of Dsh across animals to explore protein architecture and identify conserved and divergent features that could provide insight into functional specialization with an emphasis on invertebrates, especially nematodes. We find evidence of dynamic evolution of Dsh, particularly among nematodes, with taxa varying in ortholog number from one to three. We identify a new domain specific to some nematode lineages and find an unexpected nuclear localization signal conserved in many Dsh orthologs. Our findings raise questions of protein evolution in general and provide clues as to how animals have dealt with the complex intricacies of having a protein, such as Dsh, act as a central messenger hub connected to many different and vitally important pathways. We discuss our findings in the context of functional specialization and bring many testable hypotheses to light

Local trace formulae and scaling asymptotics in Toeplitz quantization

A trace formula for Toeplitz operators was proved by Boutet de Monvel and Guillemin in the setting of general Toeplitz structures. Here we give a local version of this result for a class of Toeplitz operators related to continuous groups of symmetries on quantizable compact symplectic manifolds. The local trace formula involves certain scaling asymptotics along the clean fixed locus of the Hamiltonian flow of the symbol, reminiscent of the scaling asymptotics of the equivariant components of the Szeg\"o kernel along the diagonal

2-Vector Spaces and Groupoids

This paper describes a relationship between essentially finite groupoids and 2-vector spaces. In particular, we show to construct 2-vector spaces of Vect-valued presheaves on such groupoids. We define 2-linear maps corresponding to functors between groupoids in both a covariant and contravariant way, which are ambidextrous adjoints. This is used to construct a representation--a weak functor--from Span(Gpd) (the bicategory of groupoids and spans of groupoids) into 2Vect. In this paper we prove this and give the construction in detail.Comment: 44 pages, 5 figures - v2 adds new theorem, significant changes to proofs, new sectio

The Ratio of Ortho- to Para-H2 in Photodissociation Regions

We discuss the ratio of ortho- to para-H2 in photodissociation regions (PDRs). We draw attention to an apparent confusion in the literature between the ortho-to-para ratio of molecules in FUV-pumped vibrationally excited states, and the H2 ortho-to-para abundance ratio. These ratios are not the same because the process of FUV-pumping of fluorescent H2 emission in PDRs occurs via optically thick absorption lines. Thus, gas with an equilibrium ratio of ortho- to para-H2 equal to 3 will yield FUV-pumped vibrationally excited ortho-to-para ratios smaller than 3, because the ortho-H2 pumping rates are preferentially reduced by optical depth effects. Indeed, if the ortho and para pumping lines are on the ``square root'' part of the curve-of-growth, then the expected ratio of ortho and para vibrational line strengths is the square root of 3, ~ 1.7, close to the typically observed value. Thus, contrary to what has sometimes been stated in the literature, most previous measurements of the ratio of ortho- to para-H2 in vibrationally excited states are entirely consistent with a total ortho-to-para ratio of 3, the equilibrium value for temperatures greater than 200 K. We present an analysis and several detailed models which illustrate the relationship between the total ratios of ortho- to para-H2 and the vibrationally excited ortho-to-para ratios in PDRs. Recent Infrared Space Observatory (ISO) measurements of pure rotational and vibrational H2 emissions from the PDR in the star-forming region S140 provide strong observational support for our conclusions.Comment: 23 pages (including 5 figures), LaTeX, uses aaspp4.sty, accepted for publication in Ap