Chiral order and fluctuations in multi-flavour QCD

Multi-flavour (N_f>=3) Chiral Perturbation Theory (ChPT) may exhibit instabilities due to vacuum fluctuations of sea q-bar q pairs. Keeping the fluctuations small would require a very precise fine-tuning of the low-energy constants L_4 and L_6 to L_4[crit](M_rho) = - 0.51 * 10^(-3), and L_6[crit](M_rho) = - 0.26 * 10^(-3). A small deviation from these critical values -- like the one suggested by the phenomenology of OZI-rule violation in the scalar channel -- is amplified by huge numerical factors inducing large effects of vacuum fluctuations. This would lead in particular to a strong N_f-dependence of chiral symmetry breaking and a suppression of multi-flavour chiral order parameters. A simple resummation is shown to cure the instability of N_f>=3 ChPT, but it modifies the standard expressions of some O(p^2) and O(p^4) low-energy parameters in terms of observables. On the other hand, for r=m_s/m > 15, the two-flavour condensate is not suppressed, due to the contribution induced by massive vacuum s-bar s pairs. Thanks to the latter, the standard two-flavour ChPT is protected from multi-flavour instabilities and could provide a well-defined expansion scheme in powers of non-strange quark masses.Comment: Published versio

Analysis and interpretation of new low-energy Pi-Pi scattering data

The recently published E865 data on charged K_e4 decays and Pi-Pi phases are reanalyzed to extract values of the two S-wave scattering lengths, of the subthreshold parameters alpha and beta, of the low-energy constants l3-bar and l4-bar as well as of the main two-flavour order parameters: and F_pi in the limit m_u = m_d = 0 taken at the physical value of the strange quark mass. Our analysis is exclusively based on direct experimental information on Pi-Pi phases below 800 MeV and on the new solutions of the Roy equations by Ananthanarayan et al. The result is compared with the theoretical prediction relating 2 a_0^0 - 5 a_0^2 and the scalar radius of the pion, which was obtained in two-loop Chiral Perturbation Theory. A discrepancy at the 1-sigma level is found and commented upon.Comment: Published version, to appear in Eur. Phys. J.

Capacitance of Gated GaAs/AlGaAs Heterostructures Subject to In-plane Magnetic Fields

A detailed analysis of the capacitance of gated GaAs/AlGaAs heterostructures is presented. The nonlinear dependence of the capacitance on the gate voltage and in-plane magnetic field is discussed together with the capacitance quantum steps connected with a population of higher 2D gas subbands. The results of full self-consistent numerical calculations are compared to recent experimental data.Comment: 4 pages, Revtex. 4 PostScript figures in an uuencoded compressed file available upon request. Phys. Rev.B, in pres

Electronic dummy for acoustical testing

Electronic Dummy /ED/ used for acoustical testing represents the average male torso from the Xiphoid process upward and includes an acoustic replica of the human head. This head simulates natural flesh, and has an artificial voice and artificial ears that measure sound pressures at the eardrum or the entrance to the ear canal

IR Kuiper Belt Constraints

We compute the temperature and IR signal of particles of radius $a$ and albedo $\alpha$ at heliocentric distance $R$, taking into account the emissivity effect, and give an interpolating formula for the result. We compare with analyses of COBE DIRBE data by others (including recent detection of the cosmic IR background) for various values of heliocentric distance, $R$, particle radius, $a$, and particle albedo, $\alpha$. We then apply these results to a recently-developed picture of the Kuiper belt as a two-sector disk with a nearby, low-density sector (40<R<50-90 AU) and a more distant sector with a higher density. We consider the case in which passage through a molecular cloud essentially cleans the Solar System of dust. We apply a simple model of dust production by comet collisions and removal by the Poynting-Robertson effect to find limits on total and dust masses in the near and far sectors as a function of time since such a passage. Finally we compare Kuiper belt IR spectra for various parameter values.Comment: 34 pages, LaTeX, uses aasms4.sty, 11 PostScript figures not embedded. A number of substantive comments by a particularly thoughtful referee have been addresse

Decoherence and Recoherence in Model Quantum Systems

We discuss the various manifestations of quantum decoherence in the forms of dephasing, entanglement with the environment, and revelation of "which-path" information. As a specific example, we consider an electron interference experiment. The coupling of the coherent electrons to the quantized electromagnetic field illustrates all of these versions of decoherence. This decoherence has two equivalent interpretations, in terms of photon emission or in terms of Aharonov-Bohm phase fluctuations. We consider the case when the coherent electrons are coupled to photons in a squeezed vacuum state. The time-averaged result is increased decoherence. However, if only electrons which are emitted during selected periods are counted, the decoherence can be suppressed below the level for the photon vacuum. This is the phenomenon of recoherence. This effect is closely related to the quantum violations of the weak energy condition, and is restricted by similar inequalities. We give some estimates of the magnitude of the recoherence effect and discuss prospects for observing it in an electron interferometry experiment.Comment: 8 pages, 3 figures, talk presented at the 7th Friedmann Seminar, Joao Pessoa, Brazil, July 200

On the Absence of Continuous Symmetries for Noncommutative 3-Spheres

A large class of noncommutative spherical manifolds was obtained recently from cohomology considerations. A one-parameter family of twisted 3-spheres was discovered by Connes and Landi, and later generalized to a three-parameter family by Connes and Dubois-Violette. The spheres of Connes and Landi were shown to be homogeneous spaces for certain compact quantum groups. Here we investigate whether or not this property can be extended to the noncommutative three-spheres of Connes and Dubois-Violette. Upon restricting to quantum groups which are continuous deformations of Spin(4) and SO(4) with standard co-actions, our results suggest that this is not the case.Comment: 15 pages, no figure

Cancer therapeutic potential of combinatorial immuno- and vaso-modulatory interventions

Currently, most of the basic mechanisms governing tumor-immune system interactions, in combination with modulations of tumor-associated vasculature, are far from being completely understood. Here, we propose a mathematical model of vascularized tumor growth, where the main novelty is the modeling of the interplay between functional tumor vasculature and effector cell recruitment dynamics. Parameters are calibrated on the basis of different in vivo immunocompromised Rag1-/- and wild-type (WT) BALB/c murine tumor growth experiments. The model analysis supports that tumor vasculature normalization can be a plausible and effective strategy to treat cancer when combined with appropriate immuno-stimulations. We find that improved levels of functional tumor vasculature, potentially mediated by normalization or stress alleviation strategies, can provide beneficial outcomes in terms of tumor burden reduction and growth control. Normalization of tumor blood vessels opens a therapeutic window of opportunity to augment the antitumor immune responses, as well as to reduce the intratumoral immunosuppression and induced-hypoxia due to vascular abnormalities. The potential success of normalizing tumor-associated vasculature closely depends on the effector cell recruitment dynamics and tumor sizes. Furthermore, an arbitrary increase of initial effector cell concentration does not necessarily imply a better tumor control. We evidence the existence of an optimal concentration range of effector cells for tumor shrinkage. Based on these findings, we suggest a theory-driven therapeutic proposal that optimally combines immuno- and vaso-modulatory interventions

The class II MHC protein HLA-DR1 in complex with an endogenous peptide: implications for the structural basis of the specificity of peptide binding

AbstractBackground: Class II major histocompatibility complex (MHC) proteins are cell surface glycoproteins that bind peptides and present them to T cells as part of the mechanism for detecting and responding to foreign material in the body. The peptide-binding activity exhibits allele-specific preferences for particular sidechains at some positions, although the structural basis of these preferences is not understood in detail. We have determined the 2.45 Å crystal structure of the human class II MHC protein HLA-DR1 in complex with the tight binding endogenous peptide A2(103–117) in order to discover peptide–MHC interactions that are important in determining the binding motif and to investigate conformational constraints on the bound peptide.Results: The bound peptide adopts a polyproline II-like conformation and places several sidechains within pockets in the binding site. Bound water molecules mediate MHC–peptide contacts at several sites. A tryptophan residue from the β2 ‘lower’ domain of HLA-DR1 was found to project into a pocket underneath the peptide-binding domain and may be important in modulating interdomain interactions in MHC proteins.Conclusions: The peptide-binding motif of HLA-DR1 includes an aromatic residue at position +1, an arginine residue at position +2, and a small residue at position +6 (where the numbering refers to the normal MHC class II convention); these preferences can be understood in light of interactions observed in the peptide–MHC complex. Comparison of the structure with that of another MHC–peptide complex shows that completely different peptide sequences bind in essentially the same conformation and are accommodated with only minimal rearrangement of HLA-DR1 residues. Small conformational differences that are observed appear to be important in interactions with other proteins