An evaluation of subjective experiences, effects and overall satisfaction with clozapine treatment in a UK forensic service

Objectives: Patients prescribed clozapine were surveyed to assess (a) the effects, both positive and adverse, and overall satisfaction with clozapine in comparison to previously prescribed antipsychotics and (b) the relative significance of effects experienced, both positive and adverse, in terms of impact on subjective well-being. Methods: A total of 56 male patients prescribed clozapine at a forensic psychiatric hospital were surveyed using a 27-item questionnaire. All patients had been prescribed clozapine for a minimum of 3 months. Respondents were asked to rate effects and satisfaction with clozapine treatment in comparison with previously prescribed antipsychotic medication on a five-point scale. Respondents were also asked to rate effects experienced with clozapine treatment in terms of impact on subjective well-being on a five-point scale. Results: A total of 89% of respondents reported greater satisfaction with clozapine than with previously prescribed antipsychotic medication. A majority of patients reported positive effects in terms of an improvement in their quality of life (68%) and social abilities (52%) with clozapine in comparison with previously prescribed antipsychotics. Nocturnal hypersalivation (84%) and weight gain (57%) were the most common adverse effects. Hedonic responses were assessed for each effect in order to determine the associated subjective experiences. The most positive hedonic responses were for quality of life, mood and alertness. In terms of adverse impact on subjective well-being, nocturnal hypersalivation ranked highest. Conclusions: Patients in a UK forensic sample are largely satisfied with clozapine treatment. The subjective effects of clozapine treatment should be taken into account by clinicians when assessing response. This may provide an opportunity to highlight the positive changes and prioritize management of the most undesirable adverse effects, which is likely to promote compliance and improve longer term treatment outcomes

Data report for the Siple Coast (Antarctica) project

This report presents data collected during three field seasons of glaciological studies in the Antarctica and describes the methods employed. The region investigated covers the mouths of Ice Streams B and C (the Siple Coast) and Crary Ice Rise on the Ross Ice Shelf. Measurements included in the report are as follows: surface velocity and deformation from repeated satellite geoceiver positions; surface topography from optical levelling; radar sounding of ice thickness; accumulation rates; near-surface densities and temperature profiles; and mapping from aerial photography

Frustrated quantum Heisenberg ferrimagnetic chains

We study the ground-state properties of weakly frustrated Heisenberg ferrimagnetic chains with nearest and next-nearest neighbor antiferromagnetic exchange interactions and two types of alternating sublattice spins S_1 > S_2, using 1/S spin-wave expansions, density-matrix renormalization group, and exact- diagonalization techniques. It is argued that the zero-point spin fluctuations completely destroy the classical commensurate- incommensurate continuous transition. Instead, the long-range ferrimagnetic state disappears through a discontinuous transition to a singlet state at a larger value of the frustration parameter. In the ferrimagnetic phase we find a disorder point marking the onset of incommensurate real-space short-range spin-spin correlations.Comment: 16 pages (LaTex 2.09), 6 eps figure

Density Matrix Renormalization Group Study of the Disorder Line in the Quantum ANNNI Model

We apply Density Matrix Renormalization Group methods to study the phase diagram of the quantum ANNNI model in the region of low frustration where the ferromagnetic coupling is larger than the next-nearest-neighbor antiferromagnetic one. By Finite Size Scaling on lattices with up to 80 sites we locate precisely the transition line from the ferromagnetic phase to a paramagnetic phase without spatial modulation. We then measure and analyze the spin-spin correlation function in order to determine the disorder transition line where a modulation appears. We give strong numerical support to the conjecture that the Peschel-Emery one-dimensional line actually coincides with the disorder line. We also show that the critical exponent governing the vanishing of the modulation parameter at the disorder transition is $\beta_q = 1/2$.Comment: 4 pages, 5 eps figure

A Gravitational Instability-Driven Viscosity in Self-Gravitating Accretion Disks

We derive a viscosity from gravitational instability in self-gravitating accretion disks, which has the required properties to account for the observed fast formation of the first super-massive black holes in highly redshifted quasars and for the cosmological evolution of the black hole-mass distribution.Comment: 14 pages, 1 figure, ApJ Letters (in press

Vortex-induced topological transition of the bilinear-biquadratic Heisenberg antiferromagnet on the triangular lattice

The ordering of the classical Heisenberg antiferromagnet on the triangular lattice with the the bilinear-biquadratic interaction is studied by Monte Carlo simulations. It is shown that the model exhibits a topological phase transition at a finite-temperature driven by topologically stable vortices, while the spin correlation length remains finite even at and below the transition point. The relevant vortices could be of three different types, depending on the value of the biquadratic coupling. Implications to recent experiments on the triangular antiferromagnet NiGa$_2$S$_4$ is discussed

More playful user interfaces: an introduction

In this chapter we embed recent research advances in creating playful user interfaces in a historical context. We have observations on spending leisure time, in particular predictions from previous decades and views expressed in Science Fiction novels. We confront these views and predictions with what has really happened since the advent of computers, the Internet, Worldwide Web and sensors and actuators that are increasingly becoming integrated in our environments and in devices that are with us 24/7. And, not only with us, but also connected to networks of nodes that represent people, institutions, and companies. Playful user interfaces are not only interesting for entertainment applications. Educational or behavior change supporting systems can also profit from a playful approach. The chapter concludes with a meta-level review of the chapters in this book. In this review we distinguish three views on research and application domains for playful user interfaces: (1) Designing Interactions for and by Children, (2) Designing Interactions with Nature, Animals, and Things, and (3) Designing Interactions for Arts, Performances, and Sports

Population of 13Be in a Nucleon Exchange Reaction

The neutron-unbound nucleus 13Be was populated with a nucleon-exchange reaction from a 71 MeV/u secondary 13B beam. The decay energy spectrum was reconstructed using invariant mass spectroscopy based on 12Be fragments in coincidence with neutrons. The data could be described with an s-wave resonance at E = 0.73(9) MeV with a width of Gamma = 1.98(34) MeV and a d-wave resonance at E = 2.56(13) MeV with a width of Gamma = 2.29(73) MeV. The observed spectral shape is consistent with previous one-proton removal reaction measurements from 14B.Comment: Published in Phys. Rev.