Health and sustainable development

If sustainable development is to mean anything, people must be healthy enough to benefit from it and not have their lives cut off prematurely. Development without health is meaningless. But the processes which are likely to occur in a world undergoing globalisation, climate change, urbanisation, population increase and many other changes, will impact upon human health in complex ways. Some of them will benefit us, others will create new or augmented threats to survival and health, while many others will have a complex mixture of effects

Ride quality meter

A ride quality meter is disclosed that automatically transforms vibration and noise measurements into a single number index of passenger discomfort. The noise measurements are converted into a noise discomfort value. The vibrations are converted into single axis discomfort values which are then converted into a combined axis discomfort value. The combined axis discomfort value is corrected for time duration and then summed with the noise discomfort value to obtain a total discomfort value

Discovery of a Binary Centaur

We have identified a binary companion to (42355) 2002 CR46 in our ongoing deep survey using the Hubble Space Telescope's High Resolution Camera. It is the first companion to be found around an object in a non-resonant orbit that crosses the orbits of giant planets. Objects in orbits of this kind, the Centaurs, have experienced repeated strong scattering with one or more giant planets and therefore the survival of binaries in this transient population has been in question. Monte Carlo simulations suggest, however, that binaries in (42355) 2002 CR46 -like heliocentric orbits have a high probability of survival for reasonable estimates of the binary's still-unknown system mass and separation. Because Centaurs are thought to be precursors to short period comets, the question of the existence of binary comets naturally arises; none has yet been definitively identified. The discovery of one binary in a sample of eight observed by HST suggests that binaries in this population may not be uncommon.Comment: 20 pages, 4 figures, 1 table accepted for publication in Icaru

Carnitine and fat oxidation

Fat and carbohydrate are the primary fuel sources for mitochondrial ATP production in human skeletal muscle during endurance exercise. However, fat exhibits a relatively low maximal rate of oxidation in vivo, which begins to decline at around 65% of maximal oxygen consumption (VO2max) when muscle glycogen becomes the major fuel. It is thought that if the rate of fat oxidation during endurance exercise could be augmented, then muscle glycogen depletion could be delayed and endurance improved. The purpose of the present review is to outline the role of carnitine in skeletal muscle fat oxidation and how this is influenced by the role of carnitine in muscle carbohydrate oxidation. Specifically, it will propose a novel hypothesis outlining how muscle free carnitine availability is limiting to the rate of fat oxidation. The review will also highlight recent research demonstrating that increasing the muscle carnitine pool in humans can have a significant impact upon both fat and carbohydrate metabolism during endurance exercise which is dependent upon the intensity of exercise performed

Recurrence interval analysis of high-frequency financial returns and its application to risk estimation

We investigate the probability distributions of the recurrence intervals $\tau$ between consecutive 1-min returns above a positive threshold $q>0$ or below a negative threshold $q<0$ of two indices and 20 individual stocks in China's stock market. The distributions of recurrence intervals for positive and negative thresholds are symmetric, and display power-law tails tested by three goodness-of-fit measures including the Kolmogorov-Smirnov (KS) statistic, the weighted KS statistic and the Cram\'er-von Mises criterion. Both long-term and shot-term memory effects are observed in the recurrence intervals for positive and negative thresholds $q$. We further apply the recurrence interval analysis to the risk estimation for the Chinese stock markets based on the probability $W_q(\Delta{t},t)$, Value-at-Risk (VaR) analysis and VaR analysis conditioned on preceding recurrence intervals.Comment: 17 pages, 10 figures, 1 tabl

CPT- and B-Violation: The p-pbar Sector

The CPT symmetry of relativistic quantum field theory requires the total lifetimes of particles and antiparticles be equal. Detection of pbar lifetime shorter than tau_p > O(10^32) yr would signal breakdown of CPT invariance, in combination with B-violation. The best current limit on tau_pbar, inferred from cosmic ray measurements, is about one Myr, placing lower limits on CPT-violating scales that depend on the exact mechanism. Paths to CPT breakdown within and outside ordinary quantum mechanics are sketched. Many of the limiting CPT-violating scales in pbar decay lie within the weak-to-Planck range.Comment: 6 pages, LaTeX, .sty file included; based on contribution to CPT98 Conference; minor changes, accepted by Mod. Phys. Lett.

Weekend hospitalization and additional risk of death: An analysis of inpatient data

Objective To assess whether weekend admissions to hospital and/or already being an inpatient on weekend days were associated with any additional mortality risk.Design Retrospective observational survivorship study. We analysed all admissions to the English National Health Service (NHS) during the financial year 2009/10, following up all patients for 30 days after admission and accounting for risk of death associated with diagnosis, co-morbidities, admission history, age, sex, ethnicity, deprivation, seasonality, day of admission and hospital trust, including day of death as a time dependent covariate. The principal analysis was based on time to in-hospital death.Participants National Health Service Hospitals in England.Main Outcome Measures 30 day mortality (in or out of hospital).Results There were 14,217,640 admissions included in the principal analysis, with 187,337 in-hospital deaths reported within 30 days of admission. Admission on weekend days was associated with a considerable increase in risk of subsequent death compared with admission on weekdays, hazard ratio for Sunday versus Wednesday 1.16 (95% CI 1.14 to 1.18; P < .0001), and for Saturday versus Wednesday 1.11 (95% CI 1.09 to 1.13; P < .0001). Hospital stays on weekend days were associated with a lower risk of death than midweek days, hazard ratio for being in hospital on Sunday versus Wednesday 0.92 (95% CI 0.91 to 0.94; P < .0001), and for Saturday versus Wednesday 0.95 (95% CI 0.93 to 0.96; P < .0001). Similar findings were observed on a smaller US data set.Conclusions Admission at the weekend is associated with increased risk of subsequent death within 30 days of admission. The likelihood of death actually occurring is less on a weekend day than on a mid-week day