Neurophysiology

Contains reports on three research projects.National Institutes of Health (Grant 5 RO1 NB-04985-03)Instrumentation Laboratory under the auspices of DSR Project 55-257Bioscience Division of National Aeronautics and Space Administration through Contract NSR 22-009-138Bell Telephone Laboratories, Inc. (Grant)The Teagle Foundation, Inc. (Grant)U. S. Air Force (Aerospace Medical Division) under Contract AF33(615)-388

Error Prevention Scheme with Four Particles

It is shown that a simplified version of the error correction code recently suggested by Shor exhibits manifestation of the quantum Zeno effect. Thus, under certain conditions, protection of an unknown quantum state is achieved. Error prevention procedures based on four-particle and two-particle encoding are proposed and it is argued that they have feasible practical implementations.Comment: 4 pages, RevTeX, references updated and improved protocol adde

Conditional beam splitting attack on quantum key distribution

We present a novel attack on quantum key distribution based on the idea of adaptive absorption [calsam01]. The conditional beam splitting attack is shown to be much more efficient than the conventional beam spitting attack, achieving a performance similar to the, powerful but currently unfeasible, photon number splitting attack. The implementation of the conditional beam splitting attack, based solely on linear optical elements, is well within reach of current technology.Comment: Submitted to Phys. Rev.

Neurophysiology

Contains reports on two research projects.Teagle Foundation, IncorporatedNational Institutes of HealthBell Telephone Laboratories, Incorporate

Physiology

Contains reports on seven research projects.Bell Laboratories, Inc.Ortho InstrumentsNational Institutes of Health (Grant 5 TO1 EY00090

Sex differences in responses to antiretroviral treatment in South African HIV-infected children on ritonavir-boosted lopinavir- and nevirapine-based treatment

Background: While studies of HIV-infected adults on antiretroviral treatment (ART) report no sex differences in immune recovery and virologic response but more ART-associated complications in women, sex differences in disease progression and response to ART among children have not been well assessed. The objective of this study was to evaluate for sex differences in response to ART in South African HIV-infected children who were randomized to continue ritonavir-boosted lopinavir (LPV/r)-based ART or switch to nevirapine-based ART. Methods: ART outcomes in HIV-infected boys and girls in Johannesburg, South Africa from 2005–2010 were compared. Children initiated ritonavir-boosted lopinavir (LPV/r)-based ART before 24 months of age and were randomized to remain on LPV/r or switch to nevirapine-based ART after achieving viral suppression. Children were followed for 76 weeks post-randomization and then long-term follow up continued for a minimum of 99 weeks and maximum of 245 weeks after randomization. Viral load, CD4 count, lipids, anthropometrics, drug concentrations, and adherence were measured at regular intervals. Outcomes were compared between sexes within treatment strata. Results: A total of 323 children (median age 8.8 months, IQR 5.1-13.5), including 168 boys and 155 girls, initiated LPV/r-based ART and 195 children were randomized. No sex differences in risk of virological failure (confirmed viral load >1000 copies/mL) by 156 weeks post-randomization were observed within either treatment group. Girls switched to nevirapine had more robust CD4 count improvement relative to boys in this group through 112 weeks post-randomization. In addition, girls remaining on LPV/r had higher plasma concentrations of ritonavir than boys during post-randomization visits. After a mean of 3.4 years post-randomization, girls remaining on LPV/r also had a higher total cholesterol:HDL ratio and lower mean HDL than boys on LPV/r. Conclusions: Sex differences are noted in treated HIV-infected children even at a young age, and appear to depend on treatment regimen. Future studies are warranted to determine biological mechanisms and clinical significance of these differences. Trial registration: ClinicalTrials.gov Identifier: NCT0011772

Report of the first international liver transplantation society expert panel consensus conference on renal insufficiency in liver transplantation

No abstract.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/64330/1/21877_ftp.pd