Symptoms associated with victimization in patients with schizophrenia and related disorders

Background: Patients with psychoses have an increased risk of becoming victims of violence. Previous studies have suggested that higher symptom levels are associated with a raised risk of becoming a victim of physical violence. There has been, however, no evidence on the type of symptoms that are linked with an increased risk of recent victimization. Methods: Data was taken from two studies on involuntarily admitted patients, one national study in England and an international one in six other European countries. In the week following admission, trained interviewers asked patients whether they had been victims of physical violence in the year prior to admission, and assessed symptoms on the Brief Psychiatric Rating Scale (BPRS). Only patients with a diagnosis of schizophrenia or related disorders (ICD-10 F20–29) were included in the analysis which was conducted separately for the two samples. Symptom levels assessed on the BPRS subscales were tested as predictors of victimization. Univariable and multivariable logistic regression models were fitted to estimate adjusted odds ratios. Results: Data from 383 patients in the English sample and 543 patients in the European sample was analysed. Rates of victimization were 37.8% and 28.0% respectively. In multivariable models, the BPRS manic subscale was significantly associated with victimization in both samples. Conclusions: Higher levels of manic symptoms indicate a raised risk of being a victim of violence in involuntary patients with schizophrenia and related disorders. This might be explained by higher activity levels, impaired judgement or poorer self-control in patients with manic symptoms. Such symptoms should be specifically considered in risk assessments

Excavating Childhood: Fairytales, Monsters and Abuse Survival in Lynda Barry’s What It Is

This article investigates the excavation of abused childhood in Lynda Barry’s What It Is. Looking at the centrality of childish play, fairy tales and the Gorgon in the protagonist’s effort to cope with maternal abuse, it argues that comics complicate the life narrative and allow the feminist reconfiguration of the monstrous mother of Western psychoanalysis and art

Multiple novel prostate cancer susceptibility signals identified by fine-mapping of known risk loci among Europeans

Genome-wide association studies (GWAS) have identified numerous common prostate cancer (PrCa) susceptibility loci. We have fine-mapped 64 GWAS regions known at the conclusion of the iCOGS study using large-scale genotyping and imputation in 25 723 PrCa cases and 26 274 controls of European ancestry. We detected evidence for multiple independent signals at 16 regions, 12 of which contained additional newly identified significant associations. A single signal comprising a spectrum of correlated variation was observed at 39 regions; 35 of which are now described by a novel more significantly associated lead SNP, while the originally reported variant remained as the lead SNP only in 4 regions. We also confirmed two association signals in Europeans that had been previously reported only in East-Asian GWAS. Based on statistical evidence and linkage disequilibrium (LD) structure, we have curated and narrowed down the list of the most likely candidate causal variants for each region. Functional annotation using data from ENCODE filtered for PrCa cell lines and eQTL analysis demonstrated significant enrichment for overlap with bio-features within this set. By incorporating the novel risk variants identified here alongside the refined data for existing association signals, we estimate that these loci now explain ∼38.9% of the familial relative risk of PrCa, an 8.9% improvement over the previously reported GWAS tag SNPs. This suggests that a significant fraction of the heritability of PrCa may have been hidden during the discovery phase of GWAS, in particular due to the presence of multiple independent signals within the same regio

Effect Of Polymer Branching on Degradation During Inkjet Printing

AbstractIn this paper we demonstrate the potential of high molecular weight hyperbranched methacrylate polymers for inkjet printing. Using the Strathclyde method, a series of hyperbranched poly (methylmethacrylate) polymers of increasing branch density were prepared. All hyperbranched polymers show both a significantly greater maximum printable concentration compared to equivalent linear polymers with implications for faster print speed. Increasing chain branching above a critical value across the molecular weight distribution was found to result in suppression of molecular weight degradation. This resistance to molecular degradation is because the longest chain segment being much smaller, such that upon jetting the polymer rapidly retains its thermodynamically stable Gaussian coil conformation and the full force of the constrictional flow in the print head is not passed on to the polymer and degradation is supressed. We further go on to show using Electron Paramagnetic Resonance that degradation occurs via a free radical chain scission mechanism

2023 Analysis of Apple Knowledge Navigator

An analysis of the Apple Knowledge Navigator video, focusing particularly on the aspects of conversational dialogue between its participant