Unjustifiable Means: The Inside Story of How the CIA, Pentagon, and US Government Conspired to Torture, by Mark Fallon

Fallon documents the source of misguided interrogations and torture after 9/11

Military Medical Ethics for the 21st Century: Ashgate May 2013; ISBN: 978-1-4094-3898-4.Edited by Michael L. Gross and Don Carrick

Military Medical Ethics for the 21st Century covers the broad array of vexing issues arising with warfare in the modern era. The editors anchor this volume in their observation that the past two decades have seen a dramatic increase in asymmetric warfare

Neglect of Medical Evidence of Torture in Guantánamo Bay: A Case Series

Vincent Iacopino and Stephen Xenakis review case records of nine individuals imprisoned at Guantánamo Bay which indicate that medical personnel assigned to the US Department of Defense neglected and/or concealed medical evidence of torture

Prostate-specific antigen (PSA) screening and follow-up investigations in Māori and non-Māori men in New Zealand

Text. Pairwise sequence alignment between human SCN9A and homologous genes. (DOCX 34 kb

Hydropathicity-based prediction of pain-causing NaV1.7 variants

Background: Mutation-induced variations in the functional architecture of the NaV1.7 channel protein are causally related to a broad spectrum of human pain disorders. Predicting in silico the phenotype of NaV1.7 variant is of major clinical importance; it can aid in reducing costs of in vitro pathophysiological characterization of NaV1.7 variants, as well as, in the design of drug agents for counteracting pain-disease symptoms.Results: In this work, we utilize spatial complexity of hydropathic effects toward predicting which NaV1.7 variants cause pain (and which are neutral) based on the location of corresponding mutation sites within the NaV1.7 structure. For that, we analyze topological and scaling hydropathic characteristics of the atomic environment around NaV1.7's pore and probe their spatial correlation with mutation sites. We show that pain-related mutation sites occupy structural locations in proximity to a hydrophobic patch lining the pore while clustering at a critical hydropathic-interactions distance from the selectivity filter (SF). Taken together, these observations can differentiate painrelated NaV1.7 variants from neutral ones, i.e., NaV1.7 variants not causing pain disease, with 80.5% sensitivity and 93.7% specificity [area under the receiver operating characteristics curve = 0.872].Conclusions: Our findings suggest that maintaining hydrophobic NaV1.7 interior intact, as well as, a finely-tuned (dictated by hydropathic interactions) distance from the SF might be necessary molecular conditions for physiological NaV1.7 functioning. The main advantage for using the presented predictive scheme is its negligible computational cost, as well as, hydropathicity-based biophysical rationalization.</p