Long-term effects of allergen sensitization and exposure in adult asthma: a prospective study.

BACKGROUND: : We investigated the effects of sensitization and exposure to common domestic allergens on longitudinal changes in lung function and bronchial hyperresponsiveness. METHODS: : Subjects attended 2 visits that were 4 years apart. Skin prick testing was performed and household dust samples were collected for quantification of mite, dog, and cat allergens at baseline. Measurements of lung function, exhaled nitric oxide, and bronchial hyperresponsiveness were completed at both visits. RESULTS: : Dust samples were collected in 165 of the 200 subjects completing both visits. Mean length of follow-up was 47 months. Bronchial hyperresponsiveness, measured at both visits in 86 subjects, deteriorated in those exposed to high mite allergen levels compared with those not exposed [mean (95% CI) doubling dose change PD20 = -0.44 (-1.07 to 0.19) vs 0.82 (0.27 to 1.36)], but improved in those exposed to high dog allergen levels compared with those not exposed [1.10 (0.33 to 1.86) vs 0.10 (-0.39 to 0.58)]. The associations were significant in the multivariate models. Cat allergen exposure was not associated with any changes in lung function, exhaled nitric oxide, or bronchial hyperresponsiveness. CONCLUSIONS: : In a 4-year prospective cohort of persons with asthma, exposure to high levels of dust mite allergens at baseline was associated with a subsequent increase in bronchial hyperresponsiveness

S33: Prolyl aminopeptidase in GtoPdb v.2023.1

Peptidase family S33 contains mainly exopeptidases that act at the N-terminus of peptides

S33: Prolyl aminopeptidase (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

Peptidase family S33 contains mainly exopeptidases that act at the N-terminus of peptides

Characterizing Simultaneous Embeddings with Fixed Edges

A set of planar graphs share a simultaneous embedding if they can be drawn on the same vertex set V in the plane without crossings between edges of the same graph. Fixed edges are common edges between graphs that share the same Jordan curve in the simultaneous drawings. While any number of planar graphs have a simultaneous embedding without fixed edges, determining which graphs always share a simultaneous embedding with fixed edges (SEFE) has been open. We partially close this problem by giving a necessary condition to determine when pairs of graphs have a SEFE

Characterizations of Restricted Pairs of Planar Graphs allowing Simultaneous Embeddings with Fixed Edges

A set of planar graphs share a simultaneous embedding if they can be drawn on the same vertex set V in the Euclidean plane without crossings between edges of the same graph. Fixed edges are common edges between graphs that share the same simple curve in the simultaneous drawing. Determining in polynomial time which pairs of graphs share a simultaneous embedding with ?xed edges (SEFE) has been open. We give a necessary and su?cient condition for whether a SEFE exists for pairs of graphs whose union is homeomorphic to K5 or K3,3 . This allows us to characterize the class of planar graphs that always have a SEFE with any other planar graph. We also characterize the class of biconnected outerplanar graphs that always have a SEFE with any other outerplanar graph. In both cases, we provide e?cient algorithms to compute a SEFE. Finally, we provide a linear-time decision algorithm for deciding whether a pair of biconnected outerplanar graphs has a SEFE

Characterizing Simultaneous Embeddings with Fixed Edges

A set of planar graphs share a simultaneous embedding if they can be drawn on the same vertex set V in the plane without crossings between edges of the same graph. Fixed edges are common edges between graphs that share the same Jordan curve in the simultaneous drawings. While any number of planar graphs have a simultaneous embedding without ?xed edges, determining which graphs always share a simultaneous embedding with ?xed edges (SEFE) has been open. We partially close this problem by giving a necessary condition to determine when pairs of graphs have a SEFE

Reducing Printed Circuit Board Emissions with Low-Noise Design Practices

This paper presents the results of an experiment designed to determine the effectiveness of adopting several low-noise printed circuit board (PCB) design practices. Two boards were designed and fabricated, each consisting of identical mixed signal circuitry. Several important differences were introduced between the board layouts: one board was constructed using recommended low-noise practices and the other constructed without such attention. The emissions from the two boards were then measured and compared, demonstrating an improvement in radiated emissions of up to 22 dB

MyAirCoach: The use of home-monitoring and mHealth systems to predict deterioration in asthma control and the occurrence of asthma exacerbations; Study protocol of an observational study

© Published by the BMJ Publishing Group Limited. Introduction Asthma is a variable lung condition whereby patients experience periods of controlled and uncontrolled asthma symptoms. Patients who experience prolonged periods of uncontrolled asthma have a higher incidence of exacerbations and increased morbidity and mortality rates. The ability to determine and to predict levels of asthma control and the occurrence of exacerbations is crucial in asthma management. Therefore, we aimed to determine to what extent physiological, behavioural and environmental data, obtained by mobile healthcare (mHealth) and home-monitoring sensors, as well as patient characteristics, can be used to predict episodes of uncontrolled asthma and the onset of asthma exacerbations. Methods and analysis In an 1-year observational study, patients will be provided with mHealth and home-monitoring systems to record daily measurements for the first-month (phase I) and weekly measurements during a follow-up period of 11 months (phase II). Our study population consists of 150 patients, aged ≥18 years, with a clinician's diagnosis of asthma, currently on controller medication, with uncontrolled asthma and/or minimally one exacerbation in the past 12 months. They will be enrolled over three participating centres, including Leiden, London and Manchester. Our main outcomes are the association between physiological, behavioural and environmental data and (1) the loss of asthma control and (2) the occurrence of asthma exacerbations. Ethics This study was approved by the Medical Ethics Committee of the Leiden University Medical Center in the Netherlands and by the NHS ethics service in the UK. Trial registration number NCT02774772