The effects of supplementing with constituents of flaxseed during exercise training on inflammation in older adults

This thesis evaluated supplementation with two components of flaxseed during exercise training on inflammation in older adults.Experiment 1: This experiment assessed secoisolariciresinol diglucoside (SDG) supplementation during aerobic exercise training on inflammation in older adults. Methods: One hundred subjects aged 50y or older were randomized to receive either SDG or placebo before completing a 6-month walking program. Fasting concentrations of interleukin-6 and tumor necrosis factor-á, glucose, triacylglycerol (TAG), high density lipoprotein (HDL), low density lipoprotein, and total cholesterol as well as leukocyte cell count were measured every two months while body composition, resting blood pressure, and a composite Z-score of six metabolic syndrome risk factors were assessed at baseline and 6 months. Results: Men on placebo increased metabolic syndrome composite Z-score (

Constraining alternative theories of gravity using pulsar timing arrays

The opening of the gravitational wave window by ground-based laser interferometers has made possible many new tests of gravity, including the first constraints on polarization. It is hoped that within the next decade pulsar timing will extend the window by making the first detections in the nano-Hertz frequency regime. Pulsar timing offers several advantages over ground-based interferometers for constraining the polarization of gravitational waves due to the many projections of the polarization pattern provided by the different lines of sight to the pulsars, and the enhanced response to longitudinal polarizations. Here we show that existing results from pulsar timing arrays can be used to place stringent limits on the energy density of longitudinal stochastic gravitational waves. Paradoxically however, we find that longitudinal modes will be very difficult to detect due to the large variance in the pulsar-pulsar correlation patterns for these modes. Existing upper limits on the power spectrum of pulsar timing residuals imply that the amplitude of vector longitudinal and scalar longitudinal modes at frequencies of 1/year are constrained: ${\cal A}_{\rm VL} < 4.1\times 10^{-16}$ and ${\cal A}_{\rm SL} < 3.7\times 10^{-17}$, while the bounds on the energy density for a scale invariant cosmological background are: $\Omega_{\rm VL}h^2 < 3.5 \times 10^{-11}$ and $\Omega_{\rm SL}h^2 < 3.2 \times 10^{-13}$.Comment: 5 pages, 4 figure

The building pathology of early modern London

This thesis is an exploratory study into enteric complaints and respiratory ailments in early modern London between 1500 and 1720. These two diseases are closely associated with urban environments, especially domestic housing, and they killed significant numbers during the study period. Unlike the plague, these diseases were comparatively stable from year to year and this thesis argues that this was largely related to constant exposure to defective buildings. While research into the relationship between housing and health is problematic, mainly because the inadequacy of housing is invariably associated with other hardships, such as poor nutrition and hygiene, this thesis aims to overcome this obstacle by applying new tools borrowed from the modern discipline of building pathology. This offers a contextual definition of a building defect and identifies the fundamental requirements of healthful housing. Building pathology also draws attention to the interaction of the external environment with buildings; the climate of the study period imposed extreme demands on vulnerable buildings and their services. Although there were variations in the quality of buildings occupied by different sectors of the population, the demands of the climate were largely exogenous to economy and society. Applying building pathology analysis to early modern London identifies conditions that were conducive to the spread of enteric and respiratory diseases amongst the wealthy as well as the poor. The final part of the thesis considers the social epidemiology of enteric and respiratory diseases, that is locating them within communities, spatially and residentially defined and questions whether the study of economic or social groups in the context of these two specific diseases helps or hinders epidemiology

The building pathology of early modern London

This thesis is an exploratory study into enteric complaints and respiratory ailments in early modern London between 1500 and 1720. These two diseases are closely associated with urban environments, especially domestic housing, and they killed significant numbers during the study period. Unlike the plague, these diseases were comparatively stable from year to year and this thesis argues that this was largely related to constant exposure to defective buildings. While research into the relationship between housing and health is problematic, mainly because the inadequacy of housing is invariably associated with other hardships, such as poor nutrition and hygiene, this thesis aims to overcome this obstacle by applying new tools borrowed from the modern discipline of building pathology. This offers a contextual definition of a building defect and identifies the fundamental requirements of healthful housing. Building pathology also draws attention to the interaction of the external environment with buildings; the climate of the study period imposed extreme demands on vulnerable buildings and their services. Although there were variations in the quality of buildings occupied by different sectors of the population, the demands of the climate were largely exogenous to economy and society. Applying building pathology analysis to early modern London identifies conditions that were conducive to the spread of enteric and respiratory diseases amongst the wealthy as well as the poor. The final part of the thesis considers the social epidemiology of enteric and respiratory diseases, that is locating them within communities, spatially and residentially defined and questions whether the study of economic or social groups in the context of these two specific diseases helps or hinders epidemiology

Constraining alternative polarization states of gravitational waves from individual black hole binaries using pulsar timing arrays

Pulsar timing arrays are sensitive to gravitational wave perturbations produced by individual supermassive black hole binaries during their early inspiral phase. Modified gravity theories allow for the emission of gravitational dipole radiation, which is enhanced relative to the quadrupole contribution for low orbital velocities, making the early inspiral an ideal regime to test for the presence of modified gravity effects. Using a theory-agnostic description of modified gravity theories based on the parametrized post-Einsteinian framework, we explore the possibility of detecting deviations from general relativity using simulated pulsar timing array data, and provide forecasts for the constraints that can be achieved. We generalize the enterprise pulsar timing software to account for possible additional polarization states and modifications to the phase evolution, and study how accurately the parameters of simulated signals can be recovered. We find that while a pure dipole model can partially recover a pure quadrupole signal, there is little possibility for confusion when the full model with all polarization states is used. With no signal present, and using noise levels comparable to those seen in contemporary arrays, we produce forecasts for the upper limits that can be placed on the amplitudes of alternative polarization modes as a function of the sky location of the source

Carbon Monoxide Alleviates Salt-Induced Oxidative Damage in Sorghum bicolor by Inducing the Expression of Proline Biosynthesis and Antioxidant Genes

Crop growth and yield are affected by salinity, which causes oxidative damage to plant cells. Plants respond to salinity by maintaining cellular osmotic balance, regulating ion transport, and enhancing the expression of stress-responsive genes, thereby inducing tolerance. As a byproduct of heme oxygenase (HO)-mediated degradation of heme, carbon monoxide (CO) regulates plant responses to salinity. This study investigated a CO-mediated salt stress tolerance mechanism in sorghum seedlings during germination. Sorghum seeds were germinated in the presence of 250 mM NaCl only, or in combination with a CO donor (1 and 1.5 μM hematin), HO inhibitor (5 and 10 μM zinc protoporphyrin IX; ZnPPIX), and hemoglobin (0.1 g/L Hb). Salt stress decreased the germination index (47.73%) and root length (74.31%), while hydrogen peroxide (H2O2) (193.5%), and proline (475%) contents increased. This increase correlated with induced HO (137.68%) activity and transcripts of ion-exchanger and antioxidant genes. Salt stress modified vascular bundle structure, increased metaxylem pit size (42.2%) and the Na+/K+ ratio (2.06) and altered primary and secondary metabolites. However, exogenous CO (1 μM hematin) increased the germination index (63.01%) and root length (150.59%), while H2O2 (21.94%) content decreased under salt stress. Carbon monoxide further increased proline (147.62%), restored the vascular bundle structure, decreased the metaxylem pit size (31.2%) and Na+/K+ ratio (1.46), and attenuated changes observed on primary and secondary metabolites under salt stress. Carbon monoxide increased HO activity (30.49%), protein content, and antioxidant gene transcripts. The alleviatory role of CO was abolished by Hb, whereas HO activity was slightly inhibited by ZnPPIX under salt stress. These results suggest that CO elicited salt stress tolerance by reducing oxidative damage through osmotic adjustment and by regulating the expression of HO1 and the ion exchanger and antioxidant transcripts

School performance trajectories and young adult offending: Findings from a national administrative data linkage, United Kingdom

Objectives Criminal offending and re-offending comes at a significant social and economic cost. Offending prevention therefore presents a high priority policy area. Low educational attainment is a known risk factor for offending, but little is understood about how changes in school performance over time might be associated with offending. Methods We investigated this in a large sample of n~4.3 million pupils using an administrative data linkage between two routinely-collected national datasets: the National Pupil Database (NPD) and the Police National Computer (PNC). First, we conducted growth mixture modelling using NPD data over three statutory testing years (School Years 2, 6 and 11). We then investigated the association between membership of these trajectories and subsequent conviction or caution for any criminal offence between Year 11 and age 21. Results We derived five school performance trajectories: (1) Average Consistent (n=3,497,167, 81.0%), (2) Average Increasing (n=66,383, 1.5%), (3) Average Declining (n=373,117, 8.6%), (4) Low Increasing (n=98,805, 2.3%), and (5) Low Consistent (n=281,964, 6.5%). The Average Declining group had the highest proportion of individuals who went on to be convicted or cautioned for any first offence up to age 21 (9.8%), followed by the Low Consistent (8.5%), Low Increasing (5.6%), Average Consistent (4.2%) and Average Increasing (1.5%) groups. Furthermore, as the number of offending days between Year 11 and age 21 increased (indicating repeat offending), the likelihood of having been in the Average Declining or Low Consistent groups also increased. We will also present findings from multilevel models accounting for school clustering, different offence types, and interactions. Conclusion Tentatively, findings suggest that changes in school performance could help to identify pupils who are struggling and at increased risk of criminal justice involvement, and therefore might be in need of additional support

Phase-coherent mapping of gravitational-wave backgrounds using ground-based laser interferometers

We extend the formalisms developed in Gair et al. and Cornish and van Haasteren to create maps of gravitational-wave backgrounds using a network of ground-based laser interferometers. We show that in contrast to pulsar timing arrays, which are insensitive to half of the gravitational-wave sky (the curl modes), a network of ground-based interferometers is sensitive to both the gradient and curl components of the background. The spatial separation of a network of interferometers, or of a single interferometer at different times during its rotational and orbital motion around the Sun, allows for recovery of both components. We derive expressions for the response functions of a laser interferometer in the small-antenna limit, and use these expressions to calculate the overlap reduction function for a pair of interferometers. We also construct maximum-likelihood estimates of the + and x-polarization modes of the gravitational-wave sky in terms of the response matrix for a network of ground-based interferometers, evaluated at discrete times during Earth's rotational and orbital motion around the Sun. We demonstrate the feasibility of this approach for some simple simulated backgrounds (a single point source and spatially-extended distributions having only grad or curl components), calculating maximum-likelihood sky maps and uncertainty maps based on the (pseudo)inverse of the response matrix. The distinction between this approach and standard methods for mapping gravitational-wave power is also discussed.Comment: 22 pages, 11 figure

Synthesis and characterisation of halide, separated ion pair, and hydride cyclopentadienyl iron bis(diphenylphosphino)ethane derivatives

Treatment of anhydrous FeX₂ (X = Cl, Br, I) with one equivalent of bis(diphenylphosphino)ethane (dppe) in refluxing THF afforded analytically pure white (X = Cl), light green (X = Br), and yellow (X = I) [FeX₂(dppe)]n (X = Cl, I; Br, II; I, III). Complexes I–III are excellent synthons from which to prepare a range of cyclopentadienyl derivatives. Specifically, treatment of I–III with alkali metal salts of C₅H₅ (Cp, series 1), C₅Me₅ (Cp*, series 2), C₅H₄SiMe₃ (Cp′, series 3), C₅H₃(SiMe₃)₂ (Cp′′, series 4), and C₅H₃(But)₂ (Cptt, series 5) afforded [Fe(Cp†)(Cl)(dppe)] 1Cl–5Cl, [Fe(Cp†)(Br)(dppe)] 1Br–5Br, and [Fe(Cp†)(I)(dppe)] 1I–5I (Cp† = Cp, Cp*, Cp′, Cp′′, or Cptt). Dissolution of 1I–5I in acetonitrile, or treatment of 1Cl–5Cl with Me₃SiI in acetonitrile (no halide exchange reactions were observed in other solvents) afforded the separated ion pair complexes [Fe(Cp†)(NCMe)(dppe)][I] 1SIP–5SIP. Attempts to reduce 1Cl–5Cl, 1Br–5Br, and 1I–5I with a variety of reductants (Li-Cs, KC₈, Na/Hg) were unsuccessful. Treatment of 1Cl–5Cl with LiAlH₄ gave the hydride derivatives [Fe(Cp†)(H)(dppe)] 1H–5H. This report provides a systematic account of reliable methods of preparing these complexes which may find utility in molecular wire and metal–metal bond chemistries. The complexes reported herein have been characterised by X-ray diffraction, NMR, IR, UV/Vis, and Mössbauer spectroscopies, cyclic voltammetry, density functional theory calculations, and elemental analyses, which have enabled us to elucidate the electronic structure of the complexes and probe the variation of iron redox properties as a function of varying the cyclopentadienyl or halide ligand

Domestic ventilation rates, indoor humidity and dust mite allergens : are our homes causing the asthma pandemic?

This paper is concerned with historical changes in domestic ventilation rates, relative humidity and the associated risk of house dust mite colonization. A controlled trial evaluated allergen and water vapour control measures on the level of house dust mite (HDM) Der p1 allergen and indoor humidity, concurrently with changes in lung function in 54 subjects who completed the protocol. Mechanical heat recovery ventilation units significantly reduced moisture content in the active group, while HDM allergen reservoirs in carpets and beds were reduced by circa 96%. Self reported health status confirmed a significant clinical improvement in the active group. The study can form the basis for assessing minimum winter ventilation rates that can suppress RH below the critical ambient equilibrium humidity of 60% and thus inhibit dust mite colonization and activity in temperate and maritime in' uenced climatic regions